ENSDARG00000054807


Danio rerio

Features
Gene ID: ENSDARG00000054807
  
Biological name :sec13
  
Synonyms : sec13 / SEC13 homolog, nuclear pore and COPII coat complex component
  
Possible biological names infered from orthology : P55735 / Q9D1M0
  
Species: Danio rerio
  
Chr. number: 22
Strand: 1
Band:
Gene start: 31059919
Gene end: 31083489
  
Corresponding Affymetrix probe sets: Dr.5496.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000071531
NCBI entrez gene - 798071     See in Manteia.
RefSeq - NM_213335
RefSeq Peptide - NP_998500
swissprot - Q7T2E1
ZFIN ID - ZDB-GENE-040426-2649
Ensembl - ENSDARG00000054807
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SEC13ENSGALG00000008419Gallus gallus
 SEC13ENSG00000157020Homo sapiens
 Sec13ENSMUSG00000030298Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport ISS
 biological_processGO:0007029 endoplasmic reticulum organization IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0036372 opsin transport IMP
 biological_processGO:0042462 eye photoreceptor cell development IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0055123 digestive system development IMP
 biological_processGO:0070278 extracellular matrix constituent secretion IMP
 biological_processGO:0090114 COPII-coated vesicle budding IEA
 biological_processGO:1904263 positive regulation of TORC1 signaling IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0030127 COPII vesicle coat IEA
 cellular_componentGO:0070971 endoplasmic reticulum exit site IDA
 molecular_functionGO:0005198 structural molecule activity IEA


Pathways (from Reactome)
Pathway description
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
COPII-mediated vesicle transport
MHC class II antigen presentation
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
eye cell apoptotic , abnormal
eye malformed , abnormal
Show

 ZFA:0000108 fin fin kinked , abnormal
Show

 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer nuclear pore malformed , abnormal
retinal inner nuclear layer endoplasmic reticulum morphology , abnormal
Show

 ZFA:0000123 liver liver nuclear pore malformed , abnormal
liver poly(A)+ mRNA export from nucleus decreased process quality , abnormal
liver decreased size , abnormal
liver basal lamina aplastic , abnormal
Show

 ZFA:0000140 pancreas pancreas decreased size , abnormal
pancreas poly(A)+ mRNA export from nucleus decreased process quality , abnormal
Show

 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer absent , abnormal
Show

 ZFA:0000144 retinal pigmented epithelium retinal pigmented epithelium distended , abnormal
retinal pigmented epithelium neuroepithelial cell disorganized , abnormal
retinal pigmented epithelium hypertrophic , abnormal
retinal pigmented epithelium basal lamina aplastic , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct decreased thickness , abnormal
Show

 ZFA:0000152 retina retina nuclear pore malformed , abnormal
retina disorganized , abnormal
retina has fewer parts of type retinal ganglion cell , abnormal
retina apoptotic process increased process quality , abnormal
retina poly(A)+ mRNA export from nucleus decreased process quality , abnormal
retina decreased size , abnormal
retina nucleus condensed , abnormal
Show

 ZFA:0001114 head head decreased size , abnormal
Show

 ZFA:0001161 pectoral fin pectoral fin malformed , abnormal
pectoral fin kinked , abnormal
Show

 ZFA:0001205 Meckel s cartilage Meckels cartilage malformed , abnormal
Show

 ZFA:0001249 exocrine pancreas exocrine pancreas decreased size , abnormal
Show

 ZFA:0001338 intestine intestine nuclear pore malformed , abnormal
intestine poly(A)+ mRNA export from nucleus decreased process quality , abnormal
intestine decreased thickness , abnormal
intestine decreased size , abnormal
Show

 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer disorganized , abnormal
retinal outer nuclear layer nuclear pore malformed , abnormal
retinal outer nuclear layer endoplasmic reticulum morphology , abnormal
Show

 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer absent , abnormal
Show

 ZFA:0001580 neurocranium neurocranium malformed , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 malformed , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium endoplasmic reticulum dilated , abnormal
intestinal epithelium endoplasmic reticulum distended , abnormal
intestinal epithelium cell junction loose , abnormal
Show

 ZFA:0005125 intestinal villus intestinal villus decreased length , abnormal
intestinal villus disorganized , abnormal
intestinal villus decreased amount , abnormal
Show

 ZFA:0005562 Bruch s membrane Bruchs membrane aplastic , abnormal
Show

 ZFA:0009084 chondrocyte chondrocyte disorganized , abnormal
chondrocyte deformed , abnormal
chondrocyte vacuole increased accumulation chondrocyte cytoplasm, abnormal
chondrocyte extracellular matrix decreased mass density , abnormal
chondrocyte endoplasmic reticulum morphology , abnormal
Show

 ZFA:0009111 hepatocyte hepatocyte endoplasmic reticulum morphology , abnormal
hepatocyte endoplasmic reticulum vacuolated , abnormal
Show

 ZFA:0009127 photoreceptor cell photoreceptor cell morphology , abnormal
Show

 ZFA:0009154 eye photoreceptor cell eye photoreceptor cell endoplasmic reticulum dilated , abnormal
Show

 ZFA:0009255 amacrine cell amacrine cell decreased amount , abnormal
Show

 ZFA:0009262 retinal cone cell retinal cone cell decreased amount , abnormal
Show

 ZFA:0009275 retinal rod cell retinal rod cell aplastic , abnormal
Show

 ZFA:0009280 Muller cell Muller cell disoriented , abnormal
Muller cell decreased amount , abnormal
Show

 ZFA:0009310 retinal ganglion cell retinal ganglion cell nuclear pore malformed , abnormal
retinal ganglion cell endoplasmic reticulum morphology , abnormal
retinal ganglion cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000019581 uso1 / USO1 vesicle transport factor / O60763* / Q9Z1Z0* / USO1 vesicle docking factor*  / reaction / complex
 ENSDARG00000003641 tfg / trk-fused gene / Q92734*  / reaction / complex
 ENSDARG00000006125 Q6P3K7 / csnk1db / casein kinase 1, delta b / Q9DC28* / CSNK1D* / P48730* / casein kinase 1 delta*  / reaction
 ENSDARG00000009087 cd74a / CD74 molecule, major histocompatibility complex, class II invariant chain a / CD74* / P04233* / P04441* / CD74 molecule* / CD74 antigen (invariant polypeptide of major histocompatib...  / reaction / complex
 ENSDARG00000008370 Q7T2E3 / csnk1da / casein kinase 1, delta a / CSNK1D* / P48730* / casein kinase 1 delta*  / reaction
 ENSDARG00000029663 rab1ab / RAB1A, member RAS oncogene family b / Rab1* / RAB1A* / P62821* / P62820* / Ras-related protein Rab-1A * / RAB1A, member RAS oncogene family*  / reaction / complex
 ENSDARG00000053136 b2m / Q04475 / beta-2-microglobulin / P01887* / P61769*  / reaction / complex
 ENSDARG00000071168 zmp:0000001138 / B2M* / P61769* / beta-2-microglobulin*  / complex / reaction
 ENSDARG00000103403 sar1b / secretion associated, Ras related GTPase 1B / Q9Y6B6*  / complex / reaction
 ENSDARG00000104230 Q7SZE5 / sec23a / Sec23 homolog A, COPII coat complex component / Q15436* / Q01405* / Protein transport protein Sec23A * / Sec23 homolog A, coat complex II component*  / complex / reaction
 ENSDARG00000063197 golga2 / golgin A2 / A6NMD2* / A7E2F4* / A8MQT2* / A8MZA4* / D6RF30* / F8WBI6* / A6NCC3* / A6NDK9* / A6NDN3* / H3BSY2* / I6L899* / P0CG33* / P0CJ92* / Q08379* / Q08AF8* / Q8N9W4* / Q921M4* ...  / reaction / complex
 ENSDARG00000104375 sec24a / SEC24 homolog A, COPII coat complex component / O95486*  / complex / reaction
 ENSDARG00000054807 sec13 / SEC13 homolog, nuclear pore and COPII coat complex component / P55735* / Q9D1M0*  / complex
 ENSDARG00000071906 sec24b / SEC24 homolog B, COPII coat complex component / O95487* / Sec24 related gene family, member B (S. cerevisiae)*  / complex / reaction
 ENSDARG00000100435 Q7SXP0 / sec22bb / SEC22 homolog B, vesicle trafficking protein b / SEC22B* / O08547* / O75396* / Vesicle-trafficking protein SEC22b * / SEC22 homolog B, vesicle trafficking protein (gene/p...  / complex / reaction
 ENSDARG00000015887 b2ml / beta-2-microglobulin, like / B2M* / P01887* / P61769* / beta-2-microglobulin*  / complex / reaction
 ENSDARG00000103516 sec24c / SEC24 homolog C, COPII coat complex component / P53992* / Sec24 related gene family, member C (S. cerevisiae)*  / complex / reaction
 ENSDARG00000021082 sec31a / SEC31 homolog A, COPII coat complex component / O94979* / Q3UPL0* / Protein transport protein Sec31A *  / complex / reaction
 ENSDARG00000099554 sec16b / SEC16 homolog B, endoplasmic reticulum export factor / Q91XT4* / Q96JE7* / Protein transport protein Sec16B *  / reaction / complex






 

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