ENSG00000070371


Homo sapiens

Features
Gene ID: ENSG00000070371
  
Biological name :CLTCL1
  
Synonyms : clathrin heavy chain like 1 / CLTCL1 / P53675
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: -1
Band: q11.21
Gene start: 19179473
Gene end: 19291716
  
Corresponding Affymetrix probe sets: 205944_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000479237
Ensembl peptide - ENSP00000443582
Ensembl peptide - ENSP00000480709
Ensembl peptide - ENSP00000485020
Ensembl peptide - ENSP00000481031
Ensembl peptide - ENSP00000396140
Ensembl peptide - ENSP00000441158
Ensembl peptide - ENSP00000443264
NCBI entrez gene - 8218     See in Manteia.
OMIM - 601273
RefSeq - XM_017028957
RefSeq - NM_001835
RefSeq - NM_007098
RefSeq - XM_011530401
RefSeq - XM_017028953
RefSeq - XM_017028954
RefSeq - XM_017028955
RefSeq - XM_017028956
RefSeq Peptide - NP_001826
RefSeq Peptide - NP_009029
swissprot - A0A087WXH4
swissprot - A0A087WX41
swissprot - F5H5N6
swissprot - H0Y529
swissprot - H0YGJ9
swissprot - P53675
swissprot - A0A087WV74
Ensembl - ENSG00000070371
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CLTCL1ENSGALG00000041760Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CLTC / Q00610 / clathrin heavy chainENSG0000014136784


Protein motifs (from Interpro)
Interpro ID Name
 IPR000547  Clathrin, heavy chain/VPS, 7-fold repeat
 IPR011990  Tetratricopeptide-like helical domain superfamily
 IPR012331  Clathrin, heavy chain, linker
 IPR015348  Clathrin, heavy chain, linker, core motif
 IPR016024  Armadillo-type fold
 IPR016341  Clathrin, heavy chain
 IPR022365  Clathrin, heavy chain, propeller repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000278 mitotic cell cycle IDA
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0006898 receptor-mediated endocytosis TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0042147 retrograde transport, endosome to Golgi IMP
 biological_processGO:0046326 positive regulation of glucose import IMP
 biological_processGO:0048268 clathrin coat assembly IEA
 biological_processGO:0061024 membrane organization TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005770 late endosome IDA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005819 spindle IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030130 clathrin coat of trans-Golgi network vesicle IEA
 cellular_componentGO:0030132 clathrin coat of coated pit IEA
 cellular_componentGO:0030135 coated vesicle IDA
 cellular_componentGO:0030136 clathrin-coated vesicle IDA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0045334 clathrin-coated endocytic vesicle NAS
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:0071439 clathrin complex IEA
 cellular_componentGO:0097443 sorting endosome IDA
 molecular_functionGO:0004871 obsolete signal transducer activity TAS
 molecular_functionGO:0005198 structural molecule activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0032051 clathrin light chain binding IEA


Pathways (from Reactome)
Pathway description
Gap junction degradation
Formation of annular gap junctions
EPH-ephrin mediated repulsion of cells
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109971 HSPA8 / P11142 / heat shock protein family A (Hsp70) member 8  / complex
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / complex / reaction
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / reaction / complex
 ENSG00000070371 CLTCL1 / P53675 / clathrin heavy chain like 1  / complex
 ENSG00000175416 CLTB / P09497 / clathrin light chain B  / complex
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / complex / reaction
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / reaction / complex
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex






 

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