ENSG00000072958


Homo sapiens

Features
Gene ID: ENSG00000072958
  
Biological name :AP1M1
  
Synonyms : adaptor related protein complex 1 mu 1 subunit / AP1M1 / Q9BXS5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.11
Gene start: 16197578
Gene end: 16245907
  
Corresponding Affymetrix probe sets: 223024_at (Human Genome U133 Plus 2.0 Array)   223025_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000467417
Ensembl peptide - ENSP00000467721
Ensembl peptide - ENSP00000482949
Ensembl peptide - ENSP00000468140
Ensembl peptide - ENSP00000468015
Ensembl peptide - ENSP00000291439
Ensembl peptide - ENSP00000388996
Ensembl peptide - ENSP00000411498
Ensembl peptide - ENSP00000465224
Ensembl peptide - ENSP00000466858
NCBI entrez gene - 8907     See in Manteia.
OMIM - 603535
RefSeq - NM_032493
RefSeq - NM_001130524
RefSeq - XM_017027420
RefSeq - XM_017027421
RefSeq Peptide - NP_001123996
RefSeq Peptide - NP_115882
swissprot - K7EQ90
swissprot - K7EQX3
swissprot - E7ENJ6
swissprot - Q9BXS5
swissprot - K7ER75
swissprot - A0A087WZX7
swissprot - A0A024R7K8
swissprot - K7EJL1
swissprot - K7ENA7
swissprot - K7EPJ8
Ensembl - ENSG00000072958
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap1m1ENSDARG00000096249Danio rerio
 Ap1m1ENSMUSG00000003033Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunitENSG0000012935477
AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunitENSG0000016120339
AP4M1 / O00189 / adaptor related protein complex 4 mu 1 subunitENSG0000022183828
AP3M1 / Q9Y2T2 / adaptor related protein complex 3 mu 1 subunitENSG0000018500927
AP3M2 / P53677 / adaptor related protein complex 3 mu 2 subunitENSG0000007071826


Protein motifs (from Interpro)
Interpro ID Name
 IPR001392  Clathrin adaptor, mu subunit
 IPR011012  Longin-like domain superfamily
 IPR018240  Clathrin adaptor, mu subunit, conserved site
 IPR022775  AP complex, mu/sigma subunit
 IPR028565  Mu homology domain
 IPR036168  AP-2 complex subunit mu, C-terminal superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0032438 melanosome organization IMP
 biological_processGO:0035646 endosome to melanosome transport IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030131 clathrin adaptor complex IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0030665 clathrin-coated vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0035579 specific granule membrane TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
Nef mediated downregulation of MHC class I complex cell surface expression
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex
 ENSG00000182287 AP1S2 / P56377 / adaptor related protein complex 1 sigma 2 subunit  / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex
 ENSG00000177182 CLVS1 / Q8IUQ0 / clavesin 1  / complex
 ENSG00000106367 AP1S1 / P61966 / adaptor related protein complex 1 sigma 1 subunit  / complex
 ENSG00000166747 AP1G1 / O43747 / adaptor related protein complex 1 gamma 1 subunit  / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex
 ENSG00000152056 AP1S3 / Q96PC3 / adaptor related protein complex 1 sigma 3 subunit  / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex
 ENSG00000100280 AP1B1 / Q10567 / adaptor related protein complex 1 beta 1 subunit  / complex
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex
 ENSG00000146352 CLVS2 / Q5SYC1 / clavesin 2  / complex
 ENSG00000175115 PACS1 / Q6VY07 / phosphofurin acidic cluster sorting protein 1  / reaction / complex






 

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