ENSG00000152056


Homo sapiens

Features
Gene ID: ENSG00000152056
  
Biological name :AP1S3
  
Synonyms : adaptor related protein complex 1 sigma 3 subunit / AP1S3 / Q96PC3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q36.1
Gene start: 223751686
Gene end: 223838027
  
Corresponding Affymetrix probe sets: 1555421_at (Human Genome U133 Plus 2.0 Array)   1555731_a_at (Human Genome U133 Plus 2.0 Array)   1555733_s_at (Human Genome U133 Plus 2.0 Array)   1555734_x_at (Human Genome U133 Plus 2.0 Array)   237159_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000388738
Ensembl peptide - ENSP00000401705
Ensembl peptide - ENSP00000399738
Ensembl peptide - ENSP00000397155
Ensembl peptide - ENSP00000333888
Ensembl peptide - ENSP00000379890
Ensembl peptide - ENSP00000379891
Ensembl peptide - ENSP00000387199
NCBI entrez gene - 130340     See in Manteia.
OMIM - 615781
RefSeq - NM_001039569
RefSeq - XM_011510600
RefSeq Peptide - NP_001034658
swissprot - Q96PC3
swissprot - G5E966
swissprot - B8ZZZ1
swissprot - F8W8K9
swissprot - C9JZK4
Ensembl - ENSG00000152056
  
Related genetic diseases (OMIM): 616106 - {Psoriasis 15, pustular, susceptibility to}, 616106
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ap1s3aENSDARG00000110439Danio rerio
 ap1s3bENSDARG00000027966Danio rerio
 AP1S3ENSGALG00000005171Gallus gallus
 Ap1s3ENSMUSG00000054702Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AP1S2 / P56377 / adaptor related protein complex 1 sigma 2 subunitENSG0000018228771
AP1S1 / P61966 / adaptor related protein complex 1 sigma 1 subunitENSG0000010636768
AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunitENSG0000004275340
AP4S1 / Q9Y587 / adaptor related protein complex 4 sigma 1 subunitENSG0000010047827


Protein motifs (from Interpro)
Interpro ID Name
 IPR000804  Clathrin adaptor complex, small chain
 IPR011012  Longin-like domain superfamily
 IPR016635  Adaptor protein complex, sigma subunit
 IPR022775  AP complex, mu/sigma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006605 protein targeting IMP
 biological_processGO:0006886 intracellular protein transport IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II TAS
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005765 lysosomal membrane TAS
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005905 clathrin-coated pit IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030117 membrane coat IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane TAS
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032588 trans-Golgi network membrane TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008565 protein transporter activity IEA


Pathways (from Reactome)
Pathway description
Nef mediated downregulation of MHC class I complex cell surface expression
MHC class II antigen presentation
Lysosome Vesicle Biogenesis
Golgi Associated Vesicle Biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129354 AP1M2 / Q9Y6Q5 / adaptor related protein complex 1 mu 2 subunit  / complex
 ENSG00000072958 AP1M1 / Q9BXS5 / adaptor related protein complex 1 mu 1 subunit  / complex
 ENSG00000166747 AP1G1 / O43747 / adaptor related protein complex 1 gamma 1 subunit  / complex
 ENSG00000166710 B2M / P61769 / beta-2-microglobulin  / complex / reaction
 ENSG00000141367 CLTC / Q00610 / clathrin heavy chain  / complex
 ENSG00000177182 CLVS1 / Q8IUQ0 / clavesin 1  / complex
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex
 ENSG00000019582 CD74 / P04233 / CD74 molecule  / complex
 ENSG00000100280 AP1B1 / Q10567 / adaptor related protein complex 1 beta 1 subunit  / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex
 ENSG00000122705 CLTA / P09496 / clathrin light chain A  / complex
 ENSG00000146352 CLVS2 / Q5SYC1 / clavesin 2  / complex
 ENSG00000079805 DNM2 / P50570 / dynamin 2  / complex / reaction
 ENSG00000175115 PACS1 / Q6VY07 / phosphofurin acidic cluster sorting protein 1  / complex / reaction






 

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