ENSG00000111321


Homo sapiens

Features
Gene ID: ENSG00000111321
  
Biological name :LTBR
  
Synonyms : LTBR / lymphotoxin beta receptor / P36941
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 6375045
Gene end: 6391571
  
Corresponding Affymetrix probe sets: 1559458_at (Human Genome U133 Plus 2.0 Array)   203005_at (Human Genome U133 Plus 2.0 Array)   232819_s_at (Human Genome U133 Plus 2.0 Array)   243400_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000440875
Ensembl peptide - ENSP00000438605
Ensembl peptide - ENSP00000438955
Ensembl peptide - ENSP00000228918
Ensembl peptide - ENSP00000437647
Ensembl peptide - ENSP00000437954
NCBI entrez gene - 4055     See in Manteia.
OMIM - 600979
RefSeq - XM_006718983
RefSeq - NM_001270987
RefSeq - NM_002342
RefSeq - XM_005253688
RefSeq Peptide - NP_002333
RefSeq Peptide - NP_001257916
swissprot - F5H6F8
swissprot - P36941
swissprot - F5H2E7
swissprot - F5H627
swissprot - F5H1S5
Ensembl - ENSG00000111321
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LtbrENSMUSG00000030339Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q9Y6Q6 / TNFRSF11A / TNF receptor superfamily member 11aENSG0000014165520
P20333 / TNFRSF1B / TNF receptor superfamily member 1BENSG0000002813719
O75509 / TNFRSF21 / TNF receptor superfamily member 21ENSG0000014607218
CD40 / P25942 / CD40 moleculeENSG0000010101717
O00300 / TNFRSF11B / TNF receptor superfamily member 11bENSG0000016476115
O95407 / TNFRSF6B / TNF receptor superfamily member 6bENSG0000024350915
Q92956 / TNFRSF14 / TNF receptor superfamily member 14ENSG0000015787314


Protein motifs (from Interpro)
Interpro ID Name
 IPR001368  TNFR/NGFR cysteine-rich region
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR017349  Tumour necrosis factor receptor 3
 IPR033997  Tumour necrosis factor receptor 3, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007275 multicellular organism development IBA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033209 tumor necrosis factor-mediated signaling pathway TAS
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0043011 myeloid dendritic cell differentiation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0046330 positive regulation of JNK cascade IMP
 biological_processGO:0048534 hematopoietic or lymphoid organ development IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:2001238 positive regulation of extrinsic apoptotic signaling pathway IMP
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005031 tumor necrosis factor-activated receptor activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110330 BIRC2 / Q13490 / baculoviral IAP repeat containing 2  / reaction / complex
 ENSG00000111321 LTBR / P36941 / lymphotoxin beta receptor  / complex / reaction
 ENSG00000227507 LTB / Q06643 / lymphotoxin beta  / reaction / complex
 ENSG00000226979 LTA / P01374 / lymphotoxin alpha  / reaction / complex
 ENSG00000125735 O43557 / TNFSF14 / TNF superfamily member 14  / complex / reaction
 ENSG00000127191 TRAF2 / Q12933 / TNF receptor associated factor 2  / complex / reaction
 ENSG00000023445 BIRC3 / Q13489 / baculoviral IAP repeat containing 3  / reaction / complex
 ENSG00000131323 TRAF3 / Q13114 / TNF receptor associated factor 3  / reaction / complex
 ENSG00000006062 Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14  / reaction / complex






 

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