ENSG00000198909


Homo sapiens

Features
Gene ID: ENSG00000198909
  
Biological name :MAP3K3
  
Synonyms : MAP3K3 / mitogen-activated protein kinase kinase kinase 3 / Q99759
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q23.3
Gene start: 63622415
Gene end: 63696303
  
Corresponding Affymetrix probe sets: 203514_at (Human Genome U133 Plus 2.0 Array)   227131_at (Human Genome U133 Plus 2.0 Array)   243505_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000464532
Ensembl peptide - ENSP00000464130
Ensembl peptide - ENSP00000464482
Ensembl peptide - ENSP00000354485
Ensembl peptide - ENSP00000354927
Ensembl peptide - ENSP00000461988
Ensembl peptide - ENSP00000462086
Ensembl peptide - ENSP00000462917
NCBI entrez gene - 4215     See in Manteia.
OMIM - 602539
RefSeq - XM_005257378
RefSeq - NM_002401
RefSeq - NM_203351
RefSeq - XM_005257376
RefSeq - XM_005257377
RefSeq Peptide - NP_002392
RefSeq Peptide - NP_976226
RefSeq Peptide - NP_001317360
swissprot - J3QRB6
swissprot - J3QS19
swissprot - Q99759
swissprot - J3QS54
swissprot - J3KRN4
swissprot - J3KTC4
Ensembl - ENSG00000198909
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k3ENSDARG00000060348Danio rerio
 MAP3K3ENSGALG00000000525Gallus gallus
 Map3k3ENSMUSG00000020700Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MAP3K2 / Q9Y2U5 / mitogen-activated protein kinase kinase kinase 2ENSG0000016996763
Q56UN5 / MAP3K19 / mitogen-activated protein kinase kinase kinase 19ENSG0000017660132
MAP3K1 / Q13233 / mitogen-activated protein kinase kinase kinase 1ENSG0000009501528
Q99558 / MAP3K14 / mitogen-activated protein kinase kinase kinase 14ENSG0000000606219
MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8ENSG0000010796816


Protein motifs (from Interpro)
Interpro ID Name
 IPR000270  PB1 domain
 IPR000719  Protein kinase domain
 IPR011009  Protein kinase-like domain superfamily
 IPR034879  Mitogen-activated protein kinase kinase kinase 2/3, PB1 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade TAS
 biological_processGO:0000186 activation of MAPKK activity IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0031098 stress-activated protein kinase signaling cascade IBA
 biological_processGO:0032147 activation of protein kinase activity IBA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEP
 biological_processGO:0046777 protein autophosphorylation IDA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0071864 positive regulation of cell proliferation in bone marrow IMP
 biological_processGO:0090050 positive regulation of cell migration involved in sprouting angiogenesis IGI
 biological_processGO:1900745 positive regulation of p38MAPK cascade IEA
 biological_processGO:2000773 negative regulation of cellular senescence IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IBA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000161011 Q13501 / SQSTM1 / sequestosome 1  / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex






 

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