Manteia - Molecule gene

ENSMUSG00000026321

Mus musculus

Features

Gene ID:	ENSMUSG00000026321

Biological name :	Tnfrsf11a

Synonyms :	O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A

Possible biological names infered from orthology :	Q9Y6Q6 / TNF receptor superfamily member 11a

Species:	Mus musculus

Chr. number:	1
Strand:	1
Band:	E2.1
Gene start:	105780718
Gene end:	105847981

Corresponding Affymetrix probe sets:	10349051 (MoGene1.0st) 1419214_at (Mouse Genome 430 2.0 Array) 1430259_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000027559 NCBI entrez gene - 21934 See in Manteia. MGI - MGI:1314891 RefSeq - NM_009399 RefSeq - XM_006529381 RefSeq Peptide - NP_033425 swissprot - O35305 Ensembl - ENSMUSG00000026321

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
cd40	ENSDARG00000054968	Danio rerio
tnfrsf11a	ENSDARG00000087804	Danio rerio
TNFRSF11A	ENSGALG00000045642	Gallus gallus
Q9Y6Q6	ENSG00000141655	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*	ENSMUSG00000030339	15
Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*	ENSMUSG00000017652	14
P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*	ENSMUSG00000028599	14
Q9EPU5 / Tnfrsf21 / Tumor necrosis factor receptor superfamily member 21 / O75509* / TNF receptor superfamily member 21*	ENSMUSG00000023915	14
O08712 / Tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) / O00300* / TNF receptor superfamily member 11b*	ENSMUSG00000063727	12
Tnfrsf14 / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) / Q92956* / TNF receptor superfamily member 14*	ENSMUSG00000042333	11

Protein motifs (from Interpro)

Interpro ID	Name
IPR001368	TNFR/NGFR cysteine-rich region
IPR022323	Tumour necrosis factor receptor 11
IPR022361	Tumour necrosis factor receptor 11A
IPR034040	Tumor necrosis factor receptor 11A, N-terminal

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0001503	ossification	IMP
biological_process	GO:0002250	adaptive immune response	IEA
biological_process	GO:0006955	immune response	IBA
biological_process	GO:0007275	multicellular organism development	IMP
biological_process	GO:0009314	response to radiation	IEA
biological_process	GO:0030316	osteoclast differentiation	IEA
biological_process	GO:0032496	response to lipopolysaccharide	IMP
biological_process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IMP
biological_process	GO:0034097	response to cytokine	IEA
biological_process	GO:0034612	response to tumor necrosis factor	IMP
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0042981	regulation of apoptotic process	IBA
biological_process	GO:0043507	positive regulation of JUN kinase activity	IEA
biological_process	GO:0048535	lymph node development	IMP
biological_process	GO:0051091	positive regulation of DNA-binding transcription factor activity	IEA
biological_process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IEA
biological_process	GO:0060086	circadian temperature homeostasis	IMP
biological_process	GO:0060749	mammary gland alveolus development	IMP
biological_process	GO:0070555	response to interleukin-1	IMP
biological_process	GO:0071812	positive regulation of fever generation by positive regulation of prostaglandin secretion	IMP
biological_process	GO:0071847	TNFSF11-mediated signaling pathway	IEA
biological_process	GO:0071848	positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling	IEA
biological_process	GO:0097190	apoptotic signaling pathway	IBA
cellular_component	GO:0005829	cytosol	IEA
cellular_component	GO:0005886	plasma membrane	ISO
cellular_component	GO:0005887	integral component of plasma membrane	IBA
cellular_component	GO:0009897	external side of plasma membrane	IEA
cellular_component	GO:0009986	cell surface	IDA
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0004888	transmembrane signaling receptor activity	IEA
molecular_function	GO:0005031	tumor necrosis factor-activated receptor activity	IMP
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0019955	cytokine binding	IEA
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

TNFR2 non-canonical NF-kB pathway

TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000062	increased bone density	"increased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0000067	osteopetrosis	"excessive formation of dense trabecular bone and excessive calcified cartilage formation; may lead to anemia and extramedullary hematopoiesis " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds Allelic Composition: Tnfrsf11a^tm1Wjb/Tnfrsf11a^tm1Wjb Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr
MP:0000121	failure of tooth eruption	"inability of the teeth to grow into the oral cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61295]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds Allelic Composition: Tnfrsf11a^tm1Wjb/Tnfrsf11a^tm1Wjb Genetic Background: involves: 129X1/SvJ * C57BL/6 Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0000135	reduced cortical bone thickness	"thinner than normal superficial layer of compact bone " [J:61509]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0000160	kyphosis	"forward curvature of the spine, characterized by extensive flexion. " [J:62023, J:66943, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0000165	abnormal hypertrophic chondrocyte zone	"anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0000240	extramedullary hematopoiesis	"formation and development of blood cells outside the bone marrow, e.g., in the spleen, liver, or lymph nodes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0000333	decreased bone marrow cell number	"decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0000440	domed skull		Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0000445	short snout	"reduced length of the anterior facial part of the muzzle" [J:53370]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0000547	short limbs	"reduced average length of the extremities" [MGI:CLS, J:61509]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0000599	enlarged liver	"larger than average size of the liver" [J:65146]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0000696	abnormal Peyer s patches morphology	"anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbata^tm1Faf/Tbata^tm1Faf Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0001533	abnormal skeleton physiology	"anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Rag2^tm1Fwa/Rag2^tm1Fwa,Tbata^tm1Faf/Tbata^tm1Faf Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0001777	abnormal body temperature regulation	"anomalous control of the body s heat" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr Allelic Composition: Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr,Tg(Gfap-cre)2Brn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N
MP:0001807	decreased IgA	"less than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0002238	abnormal nasal mucosa morphology	"any structural anomaly of the mucous membrane that lines the nasal cavity" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0002388	abnormal Peyer s patch epithelium morphology	"anomalous strucutre of the specialized epithelium of the Peyer s patch " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J
MP:0002389	abnormal Peyer s patch follicle morphology	"anomaly of the structure, development, or size of the Peyer s patch normally occupied by B cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J
MP:0002391	abnormal Peyer s patch germinal center morphology	"anomalous structure or differentiation of the area of the Peyer s patch where B cells proliferate and differentiate into plasma cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J
MP:0002392	abnormal Peyer s patch T cell area	"anomalous structure or development of the Peyer s patch normally occupied by T lymphcytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J
MP:0002396	abnormal hematopoietic system morphology/development	"any structural or developmental anomaly of the blood cells or the organs associated with the development and formation of blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0002896	abnormal bone mineralization	"defect in the process by which minerals are deposited into bone" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0002998	abnormal bone remodeling	"aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0003638	abnormal response/metabolism to endogenous compounds	"altered ability or inability to metabolize or respond to substances normally present in the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr Allelic Composition: Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr,Tg(Gfap-cre)2Brn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N
MP:0003789	osteosarcoma	"malignant neoplasm derived from bone" [smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Prkar1a^tm1.2Lsk/Prkar1a⁺,Tg(Col1a1-cre)1Kry/0,Trp53^tm1Brn/Trp53^tm1Brn Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB/N
MP:0003795	abnormal bone structure		Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0003829	impaired febrile response	"reduced or absent febrile response to exogenous or endogenous pyrogens" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:70534]	Show Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr Allelic Composition: Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr,Tg(Gfap-cre)2Brn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N
MP:0004918	abnormal negative T cell selection	"any anomaly in the process of elimination of immature T cells which react strongly with self-antigens" [GO:0043383]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: involves: 129S7/SvEvBrd
MP:0004982	abnormal osteoclast morphology	"any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0004985	decreased osteoclast cell number	"reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr
MP:0004986	abnormal osteoblast morphology	"any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0005232	abnormal mesenteric lymph node morphology	"anomalous structure, development, or number of the lymph nodes located in the mesentary, of which there are 3 classes: ileocolic, juxtaintestinal mesenteric, and central superior group" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0006269	abnormal mammary gland growth during pregnancy	"anomaly in the extensive and rapid branching of the mammary ducts, expansion of mammary epithelium in the stroma between the ducts with or without abnormalities in nipple maturation " [llw2:Linda Washburn , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf11a^tm1Wjb/Tnfrsf11a^tm1Wjb Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0006398	increased long bone epiphyseal plate size	"greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Timp2^tm1Pds/Timp2^tm1Pds Genetic Background: B6.129S4-Timp2^tm1Pds
MP:0006410	abnormal common myeloid progenitor cell morphology	"anomaly in the structure of the hematopoietic stem cells that are capable of forming any of the myeloid lineage cells (erythrocytes, granulocytes, thrombocytes, monocytes, and mast cells) but not cells of the lymphoid lineage" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0008024	absent lymph nodes	"absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6 Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr
MP:0008098	decreased plasma cell number	"reduced number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Nxf1^em1Haml/Nxf1^Mvb1,Pitpna^vb/Pitpna^vb Genetic Background: involves: C57BL/6 * DBA/2J
MP:0008133	decreased Peyer s patch number	"reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0008135	small Peyer s patches	"reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0008151	increased diameter of long bones	"increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0008211	decreased mature B cell number	"reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0008484	decreased spleen germinal center size	"reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]	Show Allelic Composition: Tnfrsf11a^tm1Imx/Tnfrsf11a^tm1Imx Genetic Background: involves: 129 * C57BL/6
MP:0008734	decreased susceptibility to endotoxin shock	"less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr Allelic Composition: Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr,Tg(Gfap-cre)2Brn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N
MP:0009347	increased cancellous bone thickness	"thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0009544	abnormal thymus epithelium morphology	"any structural anomaly of the supporting framework of the thymus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:17067941]	Show Allelic Composition: Rag1^tm1Mom/Rag1^tm1Mom Genetic Background: involves: 129S7/SvEvBrd
MP:0009815	decreased prostaglandin level	"reduction in the amount in the body of any of a class of mediators with effects of vasodilation, vasoconstriction, and smooth muscle stimulation" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]	Show Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr Allelic Composition: Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr,Tg(Gfap-cre)2Brn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N
MP:0010249	lactation failure	"mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Wjb/Tnfrsf11a^tm1Wjb Genetic Background: involves: 129X1/SvJ * C57BL/6
MP:0010868	increased bone trabecula number	"increased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0010875	increased bone volume	"increased amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0010878	increased trabecular bone volume	"increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0010967	increased compact bone area	"increase in the total amount of cross-sectional area of compact bone tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11a^tm1Kost/Tnfrsf11a^tm1Kost Genetic Background: involves: 129/Sv * Black Swiss
MP:0011020	abnormal circadian temperature homeostasis	"any anomaly in the process in which an organism modulates its internal body temperature at different values with a regularity of approximately 24 hours" [GO:0060086]	Show Allelic Composition: Tnfrsf11a^tm1.2Pngr/Tnfrsf11a^tm1.2Pngr Genetic Background: B6.Cg-Tnfrsf11a^tm1.2Pngr Allelic Composition: Tnfrsf11a^tm1.1Pngr/Tnfrsf11a^tm1.2Pngr,Tg(Gfap-cre)2Brn/0 Genetic Background: involves: 129 * C57BL/6 * C57BL/6NTac * FVB/N

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000021277	Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*	/ complex / reaction
ENSMUSG00000022015	O35235 / Tnfsf11 / tumor necrosis factor (ligand) superfamily, member 11 / O14788* / TNF superfamily member 11*	/ reaction / complex
ENSMUSG00000026321	O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*	/ complex / reaction
ENSMUSG00000020941	Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*	/ complex / reaction
ENSMUSG00000026942	Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*	/ reaction / complex
ENSMUSG00000057367	Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*	/ reaction / complex

0 s.

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