Manteia - Molecule gene

ENSMUSG00000063727

Mus musculus

Features

Gene ID:	ENSMUSG00000063727

Biological name :	Tnfrsf11b

Synonyms :	O08712 / Tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin)

Possible biological names infered from orthology :	O00300 / TNF receptor superfamily member 11b

Species:	Mus musculus

Chr. number:	15
Strand:	-1
Band:	D1
Gene start:	54250619
Gene end:	54278484

Corresponding Affymetrix probe sets:	10428604 (MoGene1.0st) 1418309_at (Mouse Genome 430 2.0 Array) 1449033_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000078705 NCBI entrez gene - 18383 See in Manteia. MGI - MGI:109587 RefSeq - NM_008764 RefSeq Peptide - NP_032790 swissprot - O08712 swissprot - Q3UK97 Ensembl - ENSMUSG00000063727

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tnfrsf11b	ENSDARG00000098377	Danio rerio
TNFRSF11B	ENSGALG00000043167	Gallus gallus
O00300	ENSG00000164761	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Q9EPU5 / Tnfrsf21 / Tumor necrosis factor receptor superfamily member 21 / O75509* / TNF receptor superfamily member 21*	ENSMUSG00000023915	26
P25119 / Tnfrsf1b / tumor necrosis factor receptor superfamily, member 1b / P20333* / TNF receptor superfamily member 1B*	ENSMUSG00000028599	23
O35305 / Tnfrsf11a / Tumor necrosis factor receptor superfamily member 11A / Q9Y6Q6* / TNF receptor superfamily member 11a*	ENSMUSG00000026321	19
Cd40 / P27512 / Tumor necrosis factor receptor superfamily member 5 / P25942* / CD40 molecule*	ENSMUSG00000017652	15
Tnfrsf14 / tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) / Q92956* / TNF receptor superfamily member 14*	ENSMUSG00000042333	15
Ltbr / P50284 / Tumor necrosis factor receptor superfamily member 3 / P36941* / lymphotoxin beta receptor*	ENSMUSG00000030339	15

Protein motifs (from Interpro)

Interpro ID	Name
IPR000488	Death domain
IPR001368	TNFR/NGFR cysteine-rich region
IPR011029	Death-like domain superfamily
IPR011641	Tyrosine-protein kinase ephrin type A/B receptor-like
IPR017371	Tumour necrosis factor receptor 11B
IPR022323	Tumour necrosis factor receptor 11

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0006915	apoptotic process	IEA
biological_process	GO:0006954	inflammatory response	IBA
biological_process	GO:0006955	immune response	IBA
biological_process	GO:0007165	signal transduction	IEA
biological_process	GO:0007584	response to nutrient	IEA
biological_process	GO:0010035	response to inorganic substance	IEA
biological_process	GO:0030198	extracellular matrix organization	IDA
biological_process	GO:0032026	response to magnesium ion	IEA
biological_process	GO:0032496	response to lipopolysaccharide	IBA
biological_process	GO:0033209	tumor necrosis factor-mediated signaling pathway	IEA
biological_process	GO:0042127	regulation of cell proliferation	IBA
biological_process	GO:0042489	negative regulation of odontogenesis of dentin-containing tooth	IDA
biological_process	GO:0042493	response to drug	IEA
biological_process	GO:0042981	regulation of apoptotic process	IBA
biological_process	GO:0043627	response to estrogen	IEA
biological_process	GO:0045779	negative regulation of bone resorption	IEA
biological_process	GO:0046685	response to arsenic-containing substance	IEA
biological_process	GO:0097190	apoptotic signaling pathway	IBA
cellular_component	GO:0005576	extracellular region	IEA
cellular_component	GO:0005615	extracellular space	IEA
cellular_component	GO:0005887	integral component of plasma membrane	IBA
molecular_function	GO:0005031	tumor necrosis factor-activated receptor activity	IBA
molecular_function	GO:0005515	protein binding	IPI

Pathways (from Reactome)

Pathway description

TNFs bind their physiological receptors

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000026	abnormal inner ear morphology	"malformation or malfunction of any components of the labyrinth, including the semicircular canals, vestibule and cochlea" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:1776]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0000029	abnormal malleus morphology	"structural anomaly in the largest of the three auditory ossicles, which resembles a club or hammer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0000039	abnormal otic capsule morphology	"malformation of the cartilage or bony capsule surrounding the inner ear mechanism" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:23837]	Show Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0000049	abnormal middle ear morphology	"malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0000061	fragile skeleton	"easily damaged or broken bones" [J:14208]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0000063	reduced bone density	"decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss) Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss) Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0000066	osteoporosis	"reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0000109	abnormal parietal bone morphology	"malformed curved bone forming part of the vault of the cranium" [J:17489]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0000130	abnormal cancellous bone morphology	"structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0000131	abnormal long bone epiphysis morphology	"the head of a developing long bone that is separated from the shaft by the epiphyseal plate" [J:61509]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0000272	abnormal aorta morphology	"structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0000458	abnormal mandible morphology	"malformation of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Ptprf^tm1Wjh/Ptprf^tm1Wjh,Ptprs^tm1Mtr/Ptprs^tm1Mtr Genetic Background: B6.Cg-Ptprf^tm1Wjh Ptprs^tm1Mtr
MP:0000559	abnormal femur morphology	"structural anomaly of the long bone of the thigh" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptprf^tm1Wjh/Ptprf^tm1Wjh,Ptprs^tm1Mtr/Ptprs^tm1Mtr Genetic Background: B6.Cg-Ptprf^tm1Wjh Ptprs^tm1Mtr
MP:0000685	abnormal immune system morphology	"morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptprf^tm1Wjh/Ptprf^tm1Wjh,Ptprs^tm1Mtr/Ptprs^tm1Mtr Genetic Background: B6.Cg-Ptprf^tm1Wjh Ptprs^tm1Mtr
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Kl^kl/Kl^kl,Tnfrsf11b^tm1Khs/Tnfrsf11b⁺ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b⁺ Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0001533	abnormal skeleton physiology	"anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0001541	abnormal osteoclast function	"reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0001732	postnatal growth retardation	"slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0001790	abnormal immune system physiology	"deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Ptprf^tm1Wjh/Ptprf^tm1Wjh,Ptprs^tm1Mtr/Ptprs^tm1Mtr Genetic Background: B6.Cg-Ptprf^tm1Wjh Ptprs^tm1Mtr
MP:0001967	deafness	"inability to hear" [J:57651]	Show Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0002113	abnormal skeleton development	"anomalous differentiation or remodeling of bone tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0002455	abnormal dendritic cell antigen presentation	"impairment of these specialized cells to process and present antigen to T lymphoytes" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]	Show Allelic Composition: Ptprf^tm1Wjh/Ptprf^tm1Wjh,Ptprs^tm1Mtr/Ptprs^tm1Mtr Genetic Background: B6.Cg-Ptprf^tm1Wjh Ptprs^tm1Mtr
MP:0002490	abnormal circulating immunoglobulin concentration	"deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ptprf^tm1Wjh/Ptprf^tm1Wjh,Ptprs^tm1Mtr/Ptprs^tm1Mtr Genetic Background: B6.Cg-Ptprf^tm1Wjh Ptprs^tm1Mtr
MP:0002998	abnormal bone remodeling	"aberrant process of the turnover of bone matrix that involves a balance of resorbtion and formation by osteoclasts and osteoblasts, respectively" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0003055	abnormal epiphyseal plate morphology	"malformed or absent cartilagenous center of ossification on the long bones permitting growth of the bone in both directions during development" [MeSH:National Library of Medicine - Medical Subject Headings, 2003]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0003109	short femur	"reduced length of the long bone of the thigh" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]	Show Allelic Composition: Kl^kl/Kl^kl,Tnfrsf11b^tm1Khs/Tnfrsf11b⁺ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
MP:0003723	abnormal long bone morphology	"malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0003795	abnormal bone structure		Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0003797	abnormal compact bone morphology	"structural anomaly of the outer layers of solid, hard bone that covers spongy bone; consists of parallel osteons containing mineral deposits and interstitial lamellae" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss) Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0004290	abnormal stapes footplate	"any structural abnormality in the flat portion of the stapes that fits in the oval window" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0004736	abnormal distortion product otoacoustic emission	"any abnormality in the sound produced by the cochlea in response to stimulation with 2 simultaneous tones of different frequencies; this measurement is particularly useful in assessing the functional state of OHCs" [eMedicine:http://www.emedicine.com/ent/topic372.htm, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0004737	absent distortion product otoacoustic emissions	"failure to create mechanical distortions in the inner ear when two primary tones are presented, indicating failure of outer hair cells to amplify basilar membrane motion" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0004748	increased susceptibility to age-related hearing loss	"greater than normal loss of hearing associated with advancing age, manifest as reduced ability to perceive or discriminate sounds; the pattern and age of onset vary" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0004897	otosclerosis	"formation of spongy bone in the bony labyrinth of the ear, especially adjacent to the footplate of the stapes; it may cause bony ankylosis of the stapes, resulting in conductive hearing loss; cochlear otosclerosis results in sensorineural hearing loss" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0004982	abnormal osteoclast morphology	"any structural anomaly of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0004984	increased osteoclast cell number	"greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0004986	abnormal osteoblast morphology	"any structural anomaly of a bone-forming cell, which normally forms an osseous matrix (osteoid) in which it becomes enclosed as an osteocyte" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0005017	decreased B cell number	"fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Kl^kl/Kl^kl,Tnfrsf11b^tm1Khs/Tnfrsf11b⁺ Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6
MP:0005105	abnormal middle ear ossicle morphology	"anomalous structure or development of the three small bones of the middle ear" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0005107	abnormal stapes morphology	"structural anomaly of the smallest and innermost of the three auditory ossicles" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:83132]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0005338	atherosclerotic lesions	"thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0006133	arterial calcification	"pathologic deposition of calcium salts in the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0008151	increased diameter of long bones	"increased width of the cross-sectional distance that extends from one lateral edge of a long bone, through its center and to the opposite lateral edge" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0008186	increased pro-B cell number	"greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0008214	increased immature B cell number	"greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0008233	abnormal pro-B cell differentiation	"atypical production of or inability to produce the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor
MP:0008396	abnormal osteoclast differentiation	"atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0010663	abnormal brachiocephalic trunk morphology	"any structural anomaly of the short first aortic arch branch and divides into the right subclavian artery and the right common carotid artery" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc,Tnfrsf11b^tm1Eac/Tnfrsf11b^tm1Eac Genetic Background: involves: 129S4/SvJaeSor * C57BL/6
MP:0010870	absent bone trabeculae	"absence of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0010873	decreased trabecular bone mass	"reduced total amount of trabecular bone tissue contained in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0011086	partial postnatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0011967	increased or absent threshold for auditory brainstem response	"increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1 Allelic Composition: Tnfrsf11b^tm1Khs/Tnfrsf11b^tm1Khs Genetic Background: B6.129P2-Tnfrsf11b^tm1Khs
MP:0030281	thin parietal bone	"reduced thickness of the paired membranous bones located between the frontal and occipital bones that are large, curved and quadrilateral in outline, articulate with each other at the midline in the sagittal suture, and form most of the superior and lateral aspects of the cranium" [MGI:anna]	Show Allelic Composition: Tnfrsf11b^tm1Wss/Tnfrsf11b^tm1Wss Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ * Black Swiss)
MP:0030399	abnormal incus body morphology	"any structural anomaly of the flat, main part of the incus that articulates with the head of the malleus; two spines, the short and long processes, arise from the lower posterior part of the body and diverge from each other in a right angle" [https://books.google.com/books?isbn=3642369677]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1
MP:0030400	abnormal stapes annular ligament morphology	"any structural anomaly of the ring of fibrous tissue that connects the base of the stapes to the oval window (aka fenestra vestibuli) of the inner ear" [https://en.wikipedia.org/wiki/Annular_ligament_of_stapes, UBERON:0018161]	Show Allelic Composition: Zfp423^Gt(XH542)Byg/Zfp423^tm1.2Ngc Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 * CD-1

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000022015	O35235 / Tnfsf11 / tumor necrosis factor (ligand) superfamily, member 11 / O14788* / TNF superfamily member 11*	/ reaction / complex
ENSMUSG00000063727	O08712 / Tnfrsf11b / tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) / O00300* / TNF receptor superfamily member 11b*	/ complex / reaction

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