ENSMUSG00000068105


Mus musculus

Features
Gene ID: ENSMUSG00000068105
  
Biological name :Tnfrsf13c
  
Synonyms : Q9D8D0 / Tnfrsf13c / tumor necrosis factor receptor superfamily, member 13c
  
Possible biological names infered from orthology : Q96RJ3 / TNF receptor superfamily member 13C
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: E1
Gene start: 82221743
Gene end: 82224369
  
Corresponding Affymetrix probe sets: 10430818 (MoGene1.0st)   1419307_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000086564
Ensembl peptide - ENSMUSP00000105161
Ensembl peptide - ENSMUSP00000154899
Ensembl peptide - ENSMUSP00000155840
NCBI entrez gene - 72049     See in Manteia.
MGI - MGI:1919299
RefSeq - XM_006521428
RefSeq - NM_028075
RefSeq Peptide - NP_082351
RefSeq Peptide - NP_001344687
swissprot - Q3SXS6
swissprot - Q3SXS7
swissprot - Q3U106
swissprot - Q9D8D0
Ensembl - ENSMUSG00000068105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q96RJ3ENSG00000159958Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR015336  Tumour necrosis factor receptor 13C, TALL-1 binding domain
 IPR022338  Tumour necrosis factor receptor 13C


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IMP
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002636 positive regulation of germinal center formation IMP
 biological_processGO:0030890 positive regulation of B cell proliferation IDA
 biological_processGO:0031295 T cell costimulation IMP
 biological_processGO:0031296 B cell costimulation IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IMP
 biological_processGO:0050776 regulation of immune response IMP
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA


Pathways (from Reactome)
Pathway description
TNFR2 non-canonical NF-kB pathway
TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001800 abnormal humoral immune response "abnormal immune function mediated by antibodies" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0001802 arrested B cell development "inability to produce mature B cells, and accumulation of B cell precursors" [J:52607]
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Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

Allelic Composition: Tnfrsf13cBcmd1/Tnfrsf13cBcmd1
Genetic Background: A/WySnJ

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

 MP:0002144 abnormal B lymphocyte development "atypical production of or inability to produce mature B cells, and/or accumulation of B cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Birc2tm1Rbr/Birc2tm1Rbr,Birc3tm1.1Rbr/Birc3tm1.1Rbr,Cd19tm1(cre)Cgn/Cd19+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * NZB

 MP:0002398 abnormal bone marrow cell morphology/development "anomalous structure or formation of the cells found in the bone marrow" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Oca2p-6H/Oca2p-6H
Genetic Background: involves: 101/H * C3H/HeH

 MP:0002491 decreased IgD "less than normal immunoglobulin class D level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0003132 increased number of pre-B cells "greater number of progenitor cells that form the B cell component of the immune system" [J:91592, Immunobiology, The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Tnfrsf13cBcmd1/Tnfrsf13cBcmd1
Genetic Background: A/WySnJ

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13cBcmd1/Tnfrsf13cBcmd1
Genetic Background: A/WySnJ

 MP:0004816 abnormal class switch recombination "anomaly in the rearrangement of the heavy chain genes of differentiating B cells such that the initially encoded heavy chain IgM molecule is altered to one encoding IgG, IgA or IgE; normally, this allows the body to produce antibodies with different effector functions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Chuktm1Mka/Chuktm1Mka
Genetic Background: B6.129-Chuktm1Mka

 MP:0005013 increased lymphocyte number "greater than normal white blood cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: C57BL/6

 MP:0005017 decreased B cell number "fewer than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfrsf13cBcmd1/Tnfrsf13cBcmd1
Genetic Background: A/WySnJ

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tnfrsf13cBcmd1/Tnfrsf13cBcmd1
Genetic Background: A/WySnJ

 MP:0005584 abnormal enzyme/coenzyme activity "altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Dnmt1tm2Jae/Dnmt1tm2Jae,Cd79atm1(cre)Reth/Cd79a+
Genetic Background: involves: 129S4/SvJae * BALB/c * C57BL/6

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008182 decreased marginal zone B cell number "reduced number of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Faslpr/Faslpr,Tnfrsf13cBcmd1/Tnfrsf13c+
Genetic Background: MRL.Cg-Tnfrsf13cBcmd1 Faslpr

 MP:0008183 absent marginal zone B cells "absence of CD23-negative, CD21-positive B cells of the marginal zone of the spleen expressing a B cell receptor usually reactive to bacterial cell wall components or senescent self components such as oxidized-LDL" [CL:0000845, ISBN:0781735149]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

 MP:0008186 increased pro-B cell number "greater number of the progenitor cells of the B cell lineage, with some lineage specific activity such as early stages of recombination of B cell receptor genes, but are not yet fully committed to the B cell lineage until the expression of PAX5 occurs" [CL:0000826, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

 MP:0008207 decreased B-2 cell number "reduced number of conventional B cells subject to antigenic stimulation and dependent on T cell help and with a distinct surface marker expression pattern from B-1 B cells" [CL:0000822, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:11861604]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

 MP:0008210 increased mature B cell number "greater number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm6(Map3k14*)Rsky/Gt(ROSA)26Sortm6(Map3k14*)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008211 decreased mature B cell number "reduced number of the mature form of B cells, a type of lymphocyte whose defining characteristic is the expression of an immunoglobulin complex" [CL:0000785, ISBN:0781735149]
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Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

Allelic Composition: Ightm1.2Rsky/Igh+,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: BALB/c * C57BL/6

Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Gt(ROSA)26Sortm5(Map3k14)Rsky/Gt(ROSA)26Sortm5(Map3k14)Rsky,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: C57BL/6

 MP:0008214 increased immature B cell number "greater number of the cells of the B lymphocyte lineage that have undergone VDJ rearrangement of the heavy chain and V-J rearrangement of the light chain; these cells express IgM on the cell surface but have not yet been selected for self-reactivity" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:cwg "Carroll-Ann W. Goldsmith, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

 MP:0008216 absent transitional stage B cells "absence of immature B cells of an intermediate stage between the pre-B cell stage and the mature naive stage; transitional B cells express surface immunoglobulin, and are subject to the process of B cell selection" [CL:0000818, ISBN:0781735149]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Cd19tm1(cre)Cgn/Cd19+,Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctnnb1tm2Kem/Ctnnb1tm2Kem,Emx1tm1(cre)Yql/Emx1+
Genetic Background: B6.129-Emx1tm1(cre)Yql Ctnnb1tm2Kem

Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

 MP:0008498 decreased IgG3 level "less than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13ctm1Mass/Tnfrsf13ctm1Mass
Genetic Background: C57BL/6-Tnfrsf13ctm1Mass

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tnfrsf13cBcmd1/Tnfrsf13cBcmd1
Genetic Background: A/WySnJ

 MP:0009278 abnormal bone marrow cell physiology "any functional anomaly of any of the cells found in the blood" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Cacna1ctm1Itl/Cacna1ctm1Itl
Genetic Background: B6.129S-Cacna1ctm1Itl

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031497 Q9WU72 / Tnfsf13b / tumor necrosis factor (ligand) superfamily, member 13b / Q9Y275* / TNF superfamily member 13b*  / reaction / complex
 ENSMUSG00000057367 Birc2 / Q62210 / Baculoviral IAP repeat-containing protein 2 / Q13490* / baculoviral IAP repeat containing 2*  / complex / reaction
 ENSMUSG00000021277 Traf3 / Q60803 / TNF receptor-associated factor 3 / Q13114*  / reaction / complex
 ENSMUSG00000068105 Q9D8D0 / Tnfrsf13c / tumor necrosis factor receptor superfamily, member 13c / Q96RJ3* / TNF receptor superfamily member 13C*  / reaction / complex
 ENSMUSG00000026942 Traf2 / P39429 / TNF receptor-associated factor 2 / Q12933*  / reaction / complex
 ENSMUSG00000020941 Q9WUL6 / Map3k14 / Mitogen-activated protein kinase kinase kinase 14 / Q99558*  / complex / reaction






 

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