ENSMUSG00000032109


Mus musculus

Features
Gene ID: ENSMUSG00000032109
  
Biological name :Nlrx1
  
Synonyms : NLR family member X1 / Nlrx1 / Q3TL44
  
Possible biological names infered from orthology : Q86UT6
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 44252717
Gene end: 44268599
  
Corresponding Affymetrix probe sets: 10592763 (MoGene1.0st)   1433661_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149124
Ensembl peptide - ENSMUSP00000150198
Ensembl peptide - ENSMUSP00000034621
Ensembl peptide - ENSMUSP00000126555
Ensembl peptide - ENSMUSP00000127531
NCBI entrez gene - 270151     See in Manteia.
MGI - MGI:2429611
RefSeq - NM_001163742
RefSeq - NM_001163743
RefSeq - NM_178420
RefSeq Peptide - NP_001157215
RefSeq Peptide - NP_848507
RefSeq Peptide - NP_001157214
swissprot - Q3TL44
swissprot - A0A1L1SQN7
swissprot - A0A1L1ST78
Ensembl - ENSMUSG00000032109
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlrx1ENSDARG00000073724Danio rerio
 NLRX1ENSGALG00000044053Gallus gallus
 NLRX1ENSG00000160703Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlrc3 / Q5DU56 / Protein NLRC3 / Q7RTR2* / NLR family CARD domain containing 3*ENSMUSG0000004987119
Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*ENSMUSG0000005599418
Nlrc5 / C3VPR6 / Protein NLRC5 / Q86WI3* / NLR family CARD domain containing 5*ENSMUSG0000007415117
Ciita / P79621 / MHC class II transactivator / P33076* / class II major histocompatibility complex transactivator*ENSMUSG0000002250415
Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*ENSMUSG0000003805815


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032688 negative regulation of interferon-beta production IMP
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0039536 negative regulation of RIG-I signaling pathway IMP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045824 negative regulation of innate immune response IMP
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008564 increased interferon-beta secretion "increase in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008705 increased interleukin-6 secretion "increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

 MP:0008735 increased susceptibility to endotoxin shock "more than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc17a7tm1Lex/Slc17a7+
Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000037523 Mavs / Q8VCF0 / Mitochondrial antiviral-signaling protein / Q7Z434*  / reaction / complex






 

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