ENSG00000160703


Homo sapiens

Features
Gene ID: ENSG00000160703
  
Biological name :NLRX1
  
Synonyms : NLR family member X1 / NLRX1 / Q86UT6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.3
Gene start: 119166568
Gene end: 119184016
  
Corresponding Affymetrix probe sets: 1553695_a_at (Human Genome U133 Plus 2.0 Array)   219680_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000400268
Ensembl peptide - ENSP00000387334
Ensembl peptide - ENSP00000402381
Ensembl peptide - ENSP00000433442
Ensembl peptide - ENSP00000402801
Ensembl peptide - ENSP00000292199
Ensembl peptide - ENSP00000386851
Ensembl peptide - ENSP00000386858
NCBI entrez gene - 79671     See in Manteia.
OMIM - 611947
RefSeq - XM_011542980
RefSeq - NM_001282144
RefSeq - NM_001282358
RefSeq - NM_024618
RefSeq - XM_005271669
RefSeq - XM_005271670
RefSeq - XM_005271671
RefSeq - XM_005271672
RefSeq - XM_006718904
RefSeq - NM_001282143
RefSeq Peptide - NP_001269287
RefSeq Peptide - NP_078894
RefSeq Peptide - NP_001269072
RefSeq Peptide - NP_001269073
swissprot - Q86UT6
swissprot - C9JLK8
swissprot - C9JQE9
swissprot - C9J0R6
Ensembl - ENSG00000160703
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlrx1ENSDARG00000073724Danio rerio
 NLRX1ENSGALG00000044053Gallus gallus
 Nlrx1ENSMUSG00000032109Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NLRC3 / Q7RTR2 / NLR family CARD domain containing 3ENSG0000016798419
NOD2 / Q9HC29 / nucleotide binding oligomerization domain containing 2ENSG0000016720718
NLRC5 / Q86WI3 / NLR family CARD domain containing 5ENSG0000014085317
NOD1 / Q9Y239 / nucleotide binding oligomerization domain containing 1ENSG0000010610016
CIITA / P33076 / class II major histocompatibility complex transactivatorENSG0000017958315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0032688 negative regulation of interferon-beta production IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0039536 negative regulation of RIG-I signaling pathway IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045824 negative regulation of innate immune response IEA
 biological_processGO:0050728 negative regulation of inflammatory response IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030054 cell junction IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000088888 MAVS / Q7Z434 / mitochondrial antiviral signaling protein  / reaction / complex






 

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