ENSG00000106100


Homo sapiens

Features
Gene ID: ENSG00000106100
  
Biological name :NOD1
  
Synonyms : NOD1 / nucleotide binding oligomerization domain containing 1 / Q9Y239
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: p14.3
Gene start: 30424527
Gene end: 30478784
  
Corresponding Affymetrix probe sets: 221073_s_at (Human Genome U133 Plus 2.0 Array)   224190_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000396046
Ensembl peptide - ENSP00000395551
Ensembl peptide - ENSP00000399505
Ensembl peptide - ENSP00000416946
Ensembl peptide - ENSP00000410917
Ensembl peptide - ENSP00000222823
NCBI entrez gene - 10392     See in Manteia.
OMIM - 605980
RefSeq - XM_017011675
RefSeq - XM_011515081
RefSeq - XM_011515083
RefSeq - XM_011515084
RefSeq - XM_011515085
RefSeq - XM_011515088
RefSeq - XM_017011674
RefSeq - NM_006092
RefSeq - XM_005249568
RefSeq - XM_005249572
RefSeq - XM_005249576
RefSeq - XM_006715633
RefSeq - XM_011515079
RefSeq - XM_011515080
RefSeq Peptide - NP_006083
swissprot - C9J8X8
swissprot - A0A1B0GX71
swissprot - G3XAL1
swissprot - A0A024RA73
swissprot - Q9Y239
Ensembl - ENSG00000106100
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nod1ENSDARG00000036308Danio rerio
 NOD1ENSGALG00000036807Gallus gallus
 Nod1ENSMUSG00000038058Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOD2 / Q9HC29 / nucleotide binding oligomerization domain containing 2ENSG0000016720733
NLRC3 / Q7RTR2 / NLR family CARD domain containing 3ENSG0000016798424
NLRC5 / Q86WI3 / NLR family CARD domain containing 5ENSG0000014085322
CIITA / P33076 / class II major histocompatibility complex transactivatorENSG0000017958318
NLRX1 / Q86UT6 / NLR family member X1ENSG0000016070316


Protein motifs (from Interpro)
Interpro ID Name
 IPR001315  CARD domain
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR011029  Death-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002606 positive regulation of dendritic cell antigen processing and presentation ISS
 biological_processGO:0006915 apoptotic process TAS
 biological_processGO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0006952 defense response TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0009595 detection of biotic stimulus TAS
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0016045 detection of bacterium IDA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0032731 positive regulation of interleukin-1 beta production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0042228 interleukin-8 biosynthetic process IDA
 biological_processGO:0042742 defense response to bacterium IDA
 biological_processGO:0042981 regulation of apoptotic process IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IEA
 biological_processGO:0051000 positive regulation of nitric-oxide synthase activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0051259 protein complex oligomerization TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0071225 cellular response to muramyl dipeptide IMP
 biological_processGO:1901224 positive regulation of NIK/NF-kappaB signaling IMP
 biological_processGO:1904417 positive regulation of xenophagy IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process TAS
 molecular_functionGO:0042802 identical protein binding IDA
 molecular_functionGO:0042803 protein homodimerization activity IPI
 molecular_functionGO:0042834 peptidoglycan binding TAS
 molecular_functionGO:0050700 CARD domain binding IDA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000104312 RIPK2 / O43353 / receptor interacting serine/threonine kinase 2  / reaction / complex
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / reaction / complex
 ENSG00000187796 CARD9 / Q9H257 / caspase recruitment domain family member 9  / complex / reaction
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / reaction / complex
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / complex / reaction
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / reaction / complex
 ENSG00000106100 NOD1 / Q9Y239 / nucleotide binding oligomerization domain containing 1  / reaction / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / complex / reaction
 ENSG00000118503 P21580 / TNFAIP3 / TNF alpha induced protein 3  / reaction
 ENSG00000064012 CASP8 / Q14790 / caspase 8  / complex / reaction
 ENSG00000083799 CYLD / Q9NQC7 / CYLD lysine 63 deubiquitinase  / reaction






 

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