ENSG00000140853


Homo sapiens

Features
Gene ID: ENSG00000140853
  
Biological name :NLRC5
  
Synonyms : NLRC5 / NLR family CARD domain containing 5 / Q86WI3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q13
Gene start: 56989485
Gene end: 57083531
  
Corresponding Affymetrix probe sets: 226474_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000444960
Ensembl peptide - ENSP00000443825
Ensembl peptide - ENSP00000444773
Ensembl peptide - ENSP00000262510
Ensembl peptide - ENSP00000389739
Ensembl peptide - ENSP00000437583
Ensembl peptide - ENSP00000438548
Ensembl peptide - ENSP00000439464
Ensembl peptide - ENSP00000440153
Ensembl peptide - ENSP00000440184
Ensembl peptide - ENSP00000441311
Ensembl peptide - ENSP00000441597
Ensembl peptide - ENSP00000441679
Ensembl peptide - ENSP00000441727
Ensembl peptide - ENSP00000442906
NCBI entrez gene - 84166     See in Manteia.
OMIM - 613537
RefSeq - XM_017023771
RefSeq - XM_005256197
RefSeq - XM_005256199
RefSeq - XM_005256201
RefSeq - XM_006721297
RefSeq - XM_006721298
RefSeq - XM_006721300
RefSeq - XM_011523373
RefSeq - XM_011523375
RefSeq - XM_011523376
RefSeq - XM_017023766
RefSeq - XM_017023767
RefSeq - XM_017023768
RefSeq - XM_017023769
RefSeq - XM_017023770
RefSeq - NM_001330552
RefSeq - NM_032206
RefSeq - XM_005256193
RefSeq - XM_005256194
RefSeq - XM_005256195
RefSeq - XM_005256196
RefSeq Peptide - NP_001317481
RefSeq Peptide - NP_115582
swissprot - H0YFG4
swissprot - H0YFT1
swissprot - H0YFT3
swissprot - H0YG32
swissprot - H0YGE2
swissprot - F5H274
swissprot - H0YGT6
swissprot - H0YGV6
swissprot - Q86WI3
swissprot - F5GYP0
swissprot - H0YGM1
swissprot - H0YF88
Ensembl - ENSG00000140853
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlrc5ENSDARG00000024631Danio rerio
 NLRC5ENSGALG00000001256Gallus gallus
 Nlrc5ENSMUSG00000074151Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CIITA / P33076 / class II major histocompatibility complex transactivatorENSG0000017958314
NLRC3 / Q7RTR2 / NLR family CARD domain containing 3ENSG0000016798412
NOD1 / Q9Y239 / nucleotide binding oligomerization domain containing 1ENSG0000010610011
NOD2 / Q9HC29 / nucleotide binding oligomerization domain containing 2ENSG0000016720711
NLRX1 / Q86UT6 / NLR family member X1ENSG000001607039


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR006553  Leucine-rich repeat, cysteine-containing subtype
 IPR007111  NACHT nucleoside triphosphatase
 IPR025875  Leucine rich repeat 4
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032480 negative regulation of type I interferon production TAS
 biological_processGO:0043549 regulation of kinase activity IDA
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0045345 positive regulation of MHC class I biosynthetic process IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051607 defense response to virus IEP
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0060339 negative regulation of type I interferon-mediated signaling pathway IDA
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000181481 Q8IUD6 / RNF135 / ring finger protein 135  / complex / reaction
 ENSG00000121060 Q14258 / TRIM25 / tripartite motif containing 25  / complex / reaction
 ENSG00000107201 DDX58 / O95786 / DExD/H-box helicase 58  / complex / reaction
 ENSG00000115267 IFIH1 / Q9BYX4 / interferon induced with helicase C domain 1  / complex / reaction






 

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