ENSG00000167984


Homo sapiens

Features
Gene ID: ENSG00000167984
  
Biological name :NLRC3
  
Synonyms : NLRC3 / NLR family CARD domain containing 3 / Q7RTR2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: -1
Band: p13.3
Gene start: 3539033
Gene end: 3577400
  
Corresponding Affymetrix probe sets: 236295_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000482302
Ensembl peptide - ENSP00000482989
Ensembl peptide - ENSP00000323897
Ensembl peptide - ENSP00000352039
NCBI entrez gene - 197358     See in Manteia.
OMIM - 615648
RefSeq - XM_017023039
RefSeq - XM_017023034
RefSeq - XM_017023035
RefSeq - XM_017023036
RefSeq - XM_017023037
RefSeq - XM_017023038
RefSeq - NM_178844
RefSeq - XM_017023027
RefSeq - XM_017023028
RefSeq - XM_017023029
RefSeq - XM_017023030
RefSeq - XM_017023031
RefSeq - XM_017023032
RefSeq - XM_017023033
RefSeq Peptide - NP_849172
swissprot - C3VPR7
swissprot - H3BLT9
swissprot - A0A087WZ24
swissprot - Q7RTR2
Ensembl - ENSG00000167984
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nlrc3ENSDARG00000103146Danio rerio
 NLRC3ENSGALG00000033278Gallus gallus
 Nlrc3ENSMUSG00000049871Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NOD2 / Q9HC29 / nucleotide binding oligomerization domain containing 2ENSG0000016720721
NLRC5 / Q86WI3 / NLR family CARD domain containing 5ENSG0000014085321
NOD1 / Q9Y239 / nucleotide binding oligomerization domain containing 1ENSG0000010610021
NLRX1 / Q86UT6 / NLR family member X1ENSG0000016070317
CIITA / P33076 / class II major histocompatibility complex transactivatorENSG0000017958315


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0014067 negative regulation of phosphatidylinositol 3-kinase signaling ISS
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IDA
 biological_processGO:0032687 negative regulation of interferon-alpha production ISS
 biological_processGO:0032688 negative regulation of interferon-beta production ISS
 biological_processGO:0032715 negative regulation of interleukin-6 production IMP
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IMP
 biological_processGO:0042110 T cell activation IEP
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045824 negative regulation of innate immune response ISS
 biological_processGO:0048147 negative regulation of fibroblast proliferation ISS
 biological_processGO:0050680 negative regulation of epithelial cell proliferation ISS
 biological_processGO:0050728 negative regulation of inflammatory response IDA
 biological_processGO:1900016 negative regulation of cytokine production involved in inflammatory response ISS
 biological_processGO:1900226 negative regulation of NLRP3 inflammasome complex assembly IDA
 biological_processGO:1901223 negative regulation of NIK/NF-kappaB signaling IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding ISS


Pathways (from Reactome)
Pathway description
IRF3-mediated induction of type I IFN


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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