ENSG00000100324


Homo sapiens

Features
Gene ID: ENSG00000100324
  
Biological name :TAB1
  
Synonyms : Q15750 / TAB1 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 22
Strand: 1
Band: q13.1
Gene start: 39399741
Gene end: 39437060
  
Corresponding Affymetrix probe sets: 203901_at (Human Genome U133 Plus 2.0 Array)   235827_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000333049
Ensembl peptide - ENSP00000216160
NCBI entrez gene - 10454     See in Manteia.
OMIM - 602615
RefSeq - NM_006116
RefSeq - NM_153497
RefSeq Peptide - NP_006107
RefSeq Peptide - NP_705717
swissprot - Q15750
swissprot - A8K6K3
Ensembl - ENSG00000100324
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tab1ENSDARG00000036613Danio rerio
 TAB1ENSGALG00000012150Gallus gallus
 Tab1ENSMUSG00000022414Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001932  PPM-type phosphatase domain
 IPR015655  Protein phosphatase 2C family
 IPR036457  PPM-type phosphatase domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000185 activation of MAPKKK activity TAS
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0003007 heart morphogenesis IEA
 biological_processGO:0003279 cardiac septum development IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0030324 lung development IEA
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity TAS
 biological_processGO:0060976 coronary vasculature development IEA
 biological_processGO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016607 nuclear speck IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004722 protein serine/threonine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008047 enzyme activator activity TAS
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0019209 kinase activator activity IEA
 molecular_functionGO:0048273 mitogen-activated protein kinase p38 binding IEA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
TNFR1-induced NFkappaB signaling pathway
CLEC7A (Dectin-1) signaling
Ub-specific processing proteases
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / reaction / complex
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / complex / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex
 ENSG00000164342 TLR3 / O15455 / toll like receptor 3  / reaction
 ENSG00000172175 MALT1 / Q9UDY8 / MALT1 paracaspase  / complex / reaction
 ENSG00000198286 CARD11 / Q9BXL7 / caspase recruitment domain family member 11  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / reaction / complex
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / reaction / complex
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / reaction / complex
 ENSG00000243414 Q86XR7 / TICAM2 / toll like receptor adaptor molecule 2  / complex / reaction
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / complex / reaction
 ENSG00000154589 LY96 / Q9Y6Y9 / lymphocyte antigen 96  / complex / reaction
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction / complex
 ENSG00000142867 BCL10 / O95999 / B cell CLL/lymphoma 10  / reaction / complex
 ENSG00000136869 TLR4 / O00206 / toll like receptor 4  / complex / reaction
 ENSG00000170458 CD14 / P08571 / CD14 molecule  / complex / reaction
 ENSG00000187796 CARD9 / Q9H257 / caspase recruitment domain family member 9  / complex / reaction
 ENSG00000127666 Q8IUC6 / TICAM1 / toll like receptor adaptor molecule 1  / complex / reaction
 ENSG00000184979 USP18 / Q9UMW8 / ubiquitin specific peptidase 18  / complex
 ENSG00000104312 RIPK2 / O43353 / receptor interacting serine/threonine kinase 2  / complex / reaction
 ENSG00000106100 NOD1 / Q9Y239 / nucleotide binding oligomerization domain containing 1  / reaction / complex
 ENSG00000167207 NOD2 / Q9HC29 / nucleotide binding oligomerization domain containing 2  / reaction / complex
 ENSG00000269335 IKBKG / Q9Y6K9 / inhibitor of nuclear factor kappa B kinase subunit gamma  / complex / reaction






 

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