ENSG00000244687


Homo sapiens

Features
Gene ID: ENSG00000244687
  
Biological name :UBE2V1
  
Synonyms : Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q13.13
Gene start: 50081124
Gene end: 50115959
  
Corresponding Affymetrix probe sets: 201001_s_at (Human Genome U133 Plus 2.0 Array)   201002_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000450635
Ensembl peptide - ENSP00000421351
Ensembl peptide - ENSP00000484828
Ensembl peptide - ENSP00000485599
Ensembl peptide - ENSP00000340305
Ensembl peptide - ENSP00000360720
Ensembl peptide - ENSP00000360739
Ensembl peptide - ENSP00000360742
Ensembl peptide - ENSP00000395264
Ensembl peptide - ENSP00000407770
NCBI entrez gene - 7335     See in Manteia.
OMIM - 602995
RefSeq - NM_199144
RefSeq - NM_001032288
RefSeq - NM_001257393
RefSeq - NM_001257394
RefSeq - NM_001257395
RefSeq - NM_001257396
RefSeq - NM_001257397
RefSeq - NM_001257398
RefSeq - NM_001257399
RefSeq - NM_001282575
RefSeq - NM_001282576
RefSeq - NM_001282577
RefSeq - NM_001282578
RefSeq - NM_001282579
RefSeq - NM_021988
RefSeq - NM_022442
RefSeq Peptide - NP_071887
RefSeq Peptide - NP_001269507
RefSeq Peptide - NP_001269508
RefSeq Peptide - NP_068823
RefSeq Peptide - NP_954595
RefSeq Peptide - NP_001027459
RefSeq Peptide - NP_001244322
RefSeq Peptide - NP_001244323
RefSeq Peptide - NP_001244324
RefSeq Peptide - NP_001244325
RefSeq Peptide - NP_001244326
RefSeq Peptide - NP_001244327
RefSeq Peptide - NP_001244328
RefSeq Peptide - NP_001269504
RefSeq Peptide - NP_001269505
RefSeq Peptide - NP_001269506
swissprot - Q13404
swissprot - A0A0A0MSL3
swissprot - D6RG00
swissprot - G3V2F7
Ensembl - ENSG00000244687
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ube2v1ENSDARG00000041875Danio rerio
 UBE2V1ENSGALG00000008015Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q15819 / UBE2V2 / ubiquitin conjugating enzyme E2 V2ENSG0000016913975


Protein motifs (from Interpro)
Interpro ID Name
 IPR000608  Ubiquitin-conjugating enzyme E2
 IPR016135  Ubiquitin-conjugating enzyme/RWD-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity TAS
 biological_processGO:0000209 protein polyubiquitination TAS
 biological_processGO:0002223 stimulatory C-type lectin receptor signaling pathway TAS
 biological_processGO:0006282 regulation of DNA repair TAS
 biological_processGO:0006301 postreplication repair IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0007254 JNK cascade TAS
 biological_processGO:0030154 cell differentiation NAS
 biological_processGO:0038095 Fc-epsilon receptor signaling pathway TAS
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated TAS
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0070423 nucleotide-binding oligomerization domain containing signaling pathway TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070534 protein K63-linked ubiquitination IDA
 cellular_componentGO:0000151 ubiquitin ligase complex IDA
 cellular_componentGO:0005634 nucleus TAS
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0031371 ubiquitin conjugating enzyme complex IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0035370 UBC13-UEV1A complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding IBA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000100324 TAB1 / Q15750 / TGF-beta activated kinase 1 (MAP3K7) binding protein 1  / complex
 ENSG00000157625 TAB3 / Q8N5C8 / TGF-beta activated kinase 1 and MAP3K7 binding protein 3  / complex
 ENSG00000196664 TLR7 / Q9NYK1 / toll like receptor 7  / reaction
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction
 ENSG00000172175 MALT1 / Q9UDY8 / MALT1 paracaspase  / reaction
 ENSG00000142867 BCL10 / O95999 / B cell CLL/lymphoma 10  / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000139946 PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2  / complex / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction
 ENSG00000198286 CARD11 / Q9BXL7 / caspase recruitment domain family member 11  / reaction
 ENSG00000101916 TLR8 / Q9NR97 / toll like receptor 8  / reaction
 ENSG00000197329 PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1  / complex / reaction
 ENSG00000140992 PDPK1 / O15530 / 3-phosphoinositide dependent protein kinase 1  / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / reaction / complex
 ENSG00000135341 MAP3K7 / O43318 / mitogen-activated protein kinase kinase kinase 7  / complex
 ENSG00000055208 TAB2 / Q9NYJ8 / TGF-beta activated kinase 1/MAP3K7 binding protein 2  / complex






 

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