ENSG00000197329


Homo sapiens

Features
Gene ID: ENSG00000197329
  
Biological name :PELI1
  
Synonyms : PELI1 / pellino E3 ubiquitin protein ligase 1 / Q96FA3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p14
Gene start: 64092652
Gene end: 64144454
  
Corresponding Affymetrix probe sets: 218319_at (Human Genome U133 Plus 2.0 Array)   232213_at (Human Genome U133 Plus 2.0 Array)   232304_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000351789
NCBI entrez gene - 57162     See in Manteia.
OMIM - 614797
RefSeq - XM_017004521
RefSeq - NM_020651
RefSeq - XM_011532996
RefSeq - XM_011532997
RefSeq - XM_017004520
RefSeq - XM_005264437
RefSeq - XM_011532994
RefSeq Peptide - NP_065702
swissprot - Q53T26
swissprot - Q96FA3
Ensembl - ENSG00000197329
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PELI1ENSGALG00000008837Gallus gallus
 Peli1ENSMUSG00000020134Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2ENSG0000013994682
PELI3 / Q8N2H9 / pellino E3 ubiquitin protein ligase family member 3ENSG0000017451670


Protein motifs (from Interpro)
Interpro ID Name
 IPR006800  Pellino family
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0008063 Toll signaling pathway IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0031398 positive regulation of protein ubiquitination IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IEA
 biological_processGO:0042130 negative regulation of T cell proliferation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0043331 response to dsRNA IEA
 biological_processGO:0050868 negative regulation of T cell activation IEA
 biological_processGO:0050871 positive regulation of B cell activation IEA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 biological_processGO:0070936 protein K48-linked ubiquitination IBA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity TAS
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000139946 PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2  / reaction
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / complex / reaction
 ENSG00000174516 PELI3 / Q8N2H9 / pellino E3 ubiquitin protein ligase family member 3  / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000197329 PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1  / reaction






 

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