ENSG00000139946


Homo sapiens

Features
Gene ID: ENSG00000139946
  
Biological name :PELI2
  
Synonyms : PELI2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 14
Strand: 1
Band: q22.3
Gene start: 56117814
Gene end: 56301526
  
Corresponding Affymetrix probe sets: 219132_at (Human Genome U133 Plus 2.0 Array)   230794_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000267460
Ensembl peptide - ENSP00000452666
Ensembl peptide - ENSP00000453988
NCBI entrez gene - 57161     See in Manteia.
OMIM - 614798
RefSeq - XM_017021479
RefSeq - XM_006720211
RefSeq - XM_011536990
RefSeq - XM_011536992
RefSeq - XM_017021478
RefSeq - NM_021255
RefSeq - XM_005267890
RefSeq Peptide - NP_067078
swissprot - H0YNF4
swissprot - H0YK56
swissprot - Q9HAT8
Ensembl - ENSG00000139946
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PELI2ENSGALG00000012124Gallus gallus
 Peli2ENSMUSG00000021846Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1ENSG0000019732981
PELI3 / Q8N2H9 / pellino E3 ubiquitin protein ligase family member 3ENSG0000017451670


Protein motifs (from Interpro)
Interpro ID Name
 IPR006800  Pellino family
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IBA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0008063 Toll signaling pathway IEA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling TAS
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0070498 interleukin-1-mediated signaling pathway TAS
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004674 protein serine/threonine kinase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034450 ubiquitin-ubiquitin ligase activity TAS
 molecular_functionGO:0061630 ubiquitin protein ligase activity IBA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000197329 PELI1 / Q96FA3 / pellino E3 ubiquitin protein ligase 1  / reaction
 ENSG00000139946 PELI2 / Q9HAT8 / pellino E3 ubiquitin protein ligase family member 2  / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000174516 PELI3 / Q8N2H9 / pellino E3 ubiquitin protein ligase family member 3  / reaction
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / reaction / complex
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction / complex






 

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