ENSMUSG00000020134


Mus musculus

Features
Gene ID: ENSMUSG00000020134
  
Biological name :Peli1
  
Synonyms : Peli1 / pellino 1 / Q8C669
  
Possible biological names infered from orthology : pellino E3 ubiquitin protein ligase 1 / Q96FA3
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: A3.1
Gene start: 21091291
Gene end: 21150323
  
Corresponding Affymetrix probe sets: 10374485 (MoGene1.0st)   1417371_at (Mouse Genome 430 2.0 Array)   1417372_a_at (Mouse Genome 430 2.0 Array)   1431060_at (Mouse Genome 430 2.0 Array)   1431061_s_at (Mouse Genome 430 2.0 Array)   1459398_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000090979
Ensembl peptide - ENSMUSP00000099018
NCBI entrez gene - 67245     See in Manteia.
MGI - MGI:1914495
RefSeq - XM_011243746
RefSeq - NM_023324
RefSeq Peptide - NP_075813
swissprot - Q5SRW7
swissprot - Q8C669
Ensembl - ENSMUSG00000020134
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PELI1ENSGALG00000008837Gallus gallus
 PELI1ENSG00000197329Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Peli2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8*ENSMUSG0000002184679
Peli3 / E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 / Q8N2H9* / pellino E3 ubiquitin protein ligase family member 3*ENSMUSG0000002490170


Protein motifs (from Interpro)
Interpro ID Name
 IPR006800  Pellino family
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination IMP
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0008063 Toll signaling pathway IBA
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IMP
 biological_processGO:0031398 positive regulation of protein ubiquitination IMP
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0032496 response to lipopolysaccharide IMP
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IMP
 biological_processGO:0034145 positive regulation of toll-like receptor 4 signaling pathway IMP
 biological_processGO:0042130 negative regulation of T cell proliferation IMP
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0043331 response to dsRNA IMP
 biological_processGO:0050868 negative regulation of T cell activation IMP
 biological_processGO:0050871 positive regulation of B cell activation IMP
 biological_processGO:0070936 protein K48-linked ubiquitination IDA
 cellular_componentGO:0005634 nucleus IDA
 molecular_functionGO:0004842 ubiquitin-protein transferase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0061630 ubiquitin protein ligase activity IDA


Pathways (from Reactome)
Pathway description
Interleukin-1 signaling
IRAK1 recruits IKK complex
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0000613 abnormal salivary gland morphology "malformed saliva-secreting glands of the oral cavity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:63764]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0002059 abnormal seminal gland morphology "anomalous structure of one of the two folded, sac shaped, glands that is a diverticulum of the ductus deferens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0002834 decreased heart weight "less than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0005419 hypoalbuminemia "blood albumin concentration below the normal range" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0005635 decreased circulating bilirubin level "less thant the normal concentration in the blood of this yellow heme breakdown product" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

 MP:0008463 abnormal peripheral lymph node morphology "any structural anomaly of the lymph nodes located outside the thoracic and abdominal cavities, such as the submandibular, prescapular, axillary, inguinal and popliteal lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008576 decreased circulating interferon-beta level "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0008661 decreased interleukin-10 secretion "reduction in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: a/a,Mregdsu/Mregdsu,Hps6ru/Hps6ru
Genetic Background: involves: C57BL/6J

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0008782 increased B cell apoptosis "increase in the timing or the number of B cells undergoing programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Map3k4tm1Flv/Map3k4+,X/SryAKR/J
Genetic Background: B6.Cg-Map3k4tm1Flv Chr YAKR

 MP:0010831 partial lethality "the appearance of lower than Mendelian ratios of offspring of a given genotype due to death of some, but not all of the organisms" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Peli1tm1.1Arte/Peli1tm1.1Arte
Genetic Background: involves: C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Pcsk5tm1b(KOMP)Mbp/Pcsk5tm1b(KOMP)Mbp
Genetic Background: C57BL/6N-Pcsk5tm1b(KOMP)Mbp/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031392 Irak1 / Q62406 / Interleukin-1 receptor-associated kinase 1 / P51617*  / reaction / complex
 ENSMUSG00000024901 Peli3 / E3 ubiquitin-protein ligase pellino homolog 3 isoform 2 / Q8N2H9* / pellino E3 ubiquitin protein ligase family member 3*  / reaction
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex / reaction
 ENSMUSG00000020134 Peli1 / Q8C669 / pellino 1 / Q96FA3* / pellino E3 ubiquitin protein ligase 1*  / reaction
 ENSMUSG00000021846 Peli2 / pellino E3 ubiquitin protein ligase family member 2 / Q9HAT8*  / reaction
 ENSMUSG00000059883 Irak4 / Q8R4K2 / Interleukin-1 receptor-associated kinase 4 / Q9NWZ3*  / complex / reaction






 

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