ENSG00000196664


Homo sapiens

Features
Gene ID: ENSG00000196664
  
Biological name :TLR7
  
Synonyms : Q9NYK1 / TLR7 / toll like receptor 7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.2
Gene start: 12867083
Gene end: 12890380
  
Corresponding Affymetrix probe sets: 220146_at (Human Genome U133 Plus 2.0 Array)   222952_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000370034
NCBI entrez gene - 51284     See in Manteia.
OMIM - 300365
RefSeq - NM_016562
RefSeq Peptide - NP_057646
swissprot - B2R9N9
swissprot - Q9NYK1
Ensembl - ENSG00000196664
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr7ENSDARG00000068812Danio rerio
 TLR7ENSGALG00000016590Gallus gallus
 Tlr7ENSMUSG00000044583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR8 / Q9NR97 / toll like receptor 8ENSG0000010191643
AC097637.1ENSG0000017336635
TLR9 / Q9NR96 / toll like receptor 9ENSG0000023973234
TLR3 / O15455 / toll like receptor 3ENSG0000016434221
TLR4 / O00206 / toll like receptor 4ENSG0000013686918
TLR2 / O60603 / toll like receptor 2ENSG0000013746218
TLR5 / O60602 / toll like receptor 5ENSG0000018755417
TLR10 / Q9BXR5 / toll like receptor 10ENSG0000017412316
CD180 / Q99467 / CD180 moleculeENSG0000013406115
TLR1 / Q15399 / toll like receptor 1ENSG0000017412514
TLR6 / Q9Y2C9 / toll like receptor 6ENSG0000017413014


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR026880  Toll-like receptor 7
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0002224 toll-like receptor signaling pathway TAS
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation IDA
 biological_processGO:0032722 positive regulation of chemokine production IDA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0034154 toll-like receptor 7 signaling pathway IBA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway TAS
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IDA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process IDA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IDA
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process IMP
 biological_processGO:0050729 positive regulation of inflammatory response IC
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005764 lysosome ISS
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0032009 early phagosome ISS
 cellular_componentGO:0036020 endolysosome membrane TAS
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0045335 phagocytic vesicle IEA
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding ISS
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008144 drug binding IEA
 molecular_functionGO:0035197 siRNA binding ISS


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Toll Like Receptor 7/8 (TLR7/8) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000110057 Q9H1C4 / UNC93B1 / unc-93 homolog B1, TLR signaling regulator  / complex / reaction
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / reaction / complex
 ENSG00000166598 P14625 / HSP90B1 / heat shock protein 90 beta family member 1  / complex / reaction
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / reaction / complex
 ENSG00000239732 TLR9 / Q9NR96 / toll like receptor 9  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / reaction / complex
 ENSG00000137161 CNPY3 / Q9BT09 / canopy FGF signaling regulator 3  / complex / reaction
 ENSG00000196664 TLR7 / Q9NYK1 / toll like receptor 7  / reaction / complex
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / reaction / complex






 

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