ENSG00000187554


Homo sapiens

Features
Gene ID: ENSG00000187554
  
Biological name :TLR5
  
Synonyms : O60602 / TLR5 / toll like receptor 5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q41
Gene start: 223109406
Gene end: 223143282
  
Corresponding Affymetrix probe sets: 210166_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000355846
Ensembl peptide - ENSP00000440643
Ensembl peptide - ENSP00000493892
Ensembl peptide - ENSP00000496355
Ensembl peptide - ENSP00000385458
NCBI entrez gene - 7100     See in Manteia.
OMIM - 603031
RefSeq - XM_017002208
RefSeq - NM_003268
RefSeq - XM_006711505
RefSeq - XM_006711506
RefSeq - XM_011509937
RefSeq - XM_005273241
RefSeq - XM_005273242
RefSeq - XM_005273243
RefSeq - XM_006711504
RefSeq Peptide - NP_003259
swissprot - O60602
swissprot - B1AZ06
Ensembl - ENSG00000187554
  
Related genetic diseases (OMIM): 601744 - {Systemic lupus erythematosus, resistance to}, 601744
  608556 - {Legionnaire disease, susceptibility to}, 608556
  615557 - {Melioidosis, susceptibility to}, 615557
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr5aENSDARG00000044415Danio rerio
 tlr5bENSDARG00000052322Danio rerio
 TLR5ENSGALG00000009392Gallus gallus
 Tlr5ENSMUSG00000079164Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR3 / O15455 / toll like receptor 3ENSG0000016434222
TLR8 / Q9NR97 / toll like receptor 8ENSG0000010191622
TLR9 / Q9NR96 / toll like receptor 9ENSG0000023973221
AC097637.1ENSG0000017336621
TLR7 / Q9NYK1 / toll like receptor 7ENSG0000019666421
TLR4 / O00206 / toll like receptor 4ENSG0000013686920
TLR2 / O60603 / toll like receptor 2ENSG0000013746219
TLR6 / Q9Y2C9 / toll like receptor 6ENSG0000017413018
TLR10 / Q9BXR5 / toll like receptor 10ENSG0000017412317
TLR1 / Q15399 / toll like receptor 1ENSG0000017412517
CD180 / Q99467 / CD180 moleculeENSG0000013406115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027176  Toll-like receptor 5
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0008584 male gonad development IEP
 biological_processGO:0032757 positive regulation of interleukin-8 production IDA
 biological_processGO:0034123 positive regulation of toll-like receptor signaling pathway IDA
 biological_processGO:0034146 toll-like receptor 5 signaling pathway TAS
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IDA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEP
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0005149 interleukin-1 receptor binding IPI
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 5 (TLR5) Cascade
MyD88 deficiency (TLR5)
IRAK4 deficiency (TLR5)
MyD88 cascade initiated on plasma membrane


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / reaction / complex
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / reaction / complex
 ENSG00000187554 TLR5 / O60602 / toll like receptor 5  / reaction / complex






 

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