ENSG00000101916


Homo sapiens

Features
Gene ID: ENSG00000101916
  
Biological name :TLR8
  
Synonyms : Q9NR97 / TLR8 / toll like receptor 8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: p22.2
Gene start: 12906620
Gene end: 12923169
  
Corresponding Affymetrix probe sets: 220832_at (Human Genome U133 Plus 2.0 Array)   229560_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000218032
Ensembl peptide - ENSP00000312082
NCBI entrez gene - 51311     See in Manteia.
OMIM - 300366
RefSeq - XM_011545530
RefSeq - NM_016610
RefSeq - NM_138636
RefSeq - XM_011545529
RefSeq Peptide - NP_057694
RefSeq Peptide - NP_619542
swissprot - Q9NR97
Ensembl - ENSG00000101916
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLR8ENSDARG00000104832Danio rerio
 tlr8bENSDARG00000073675Danio rerio
 Tlr8ENSMUSG00000040522Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR7 / Q9NYK1 / toll like receptor 7ENSG0000019666442
TLR9 / Q9NR96 / toll like receptor 9ENSG0000023973234
AC097637.1ENSG0000017336634
TLR3 / O15455 / toll like receptor 3ENSG0000016434221
TLR4 / O00206 / toll like receptor 4ENSG0000013686919
TLR5 / O60602 / toll like receptor 5ENSG0000018755418
TLR10 / Q9BXR5 / toll like receptor 10ENSG0000017412317
TLR2 / O60603 / toll like receptor 2ENSG0000013746217
TLR1 / Q15399 / toll like receptor 1ENSG0000017412516
TLR6 / Q9Y2C9 / toll like receptor 6ENSG0000017413016
CD180 / Q99467 / CD180 moleculeENSG0000013406115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027175  Toll-like receptor 8
 IPR032675  Leucine-rich repeat domain superfamily
 IPR035897  Toll/interleukin-1 receptor homology (TIR) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001774 microglial cell activation IEA
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0009615 response to virus IDA
 biological_processGO:0016064 immunoglobulin mediated immune response TAS
 biological_processGO:0034158 toll-like receptor 8 signaling pathway IDA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway TAS
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IDA
 biological_processGO:0045087 innate immune response NAS
 biological_processGO:0045089 positive regulation of innate immune response IDA
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process IDA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IDA
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process IMP
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IDA
 biological_processGO:0051607 defense response to virus IMP
 biological_processGO:0071260 cellular response to mechanical stimulus IEP
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IDA
 biological_processGO:2001183 negative regulation of interleukin-12 secretion IDA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0010008 endosome membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0036020 endolysosome membrane TAS
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003725 double-stranded RNA binding IDA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008144 drug binding IEA


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Toll Like Receptor 7/8 (TLR7/8) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex / reaction
 ENSG00000198001 IRAK4 / Q9NWZ3 / interleukin 1 receptor associated kinase 4  / complex / reaction
 ENSG00000185507 IRF7 / Q92985 / interferon regulatory factor 7  / complex / reaction
 ENSG00000184216 IRAK1 / P51617 / interleukin 1 receptor associated kinase 1  / complex / reaction
 ENSG00000101916 TLR8 / Q9NR97 / toll like receptor 8  / complex
 ENSG00000110057 Q9H1C4 / UNC93B1 / unc-93 homolog B1, TLR signaling regulator  / complex / reaction
 ENSG00000134070 IRAK2 / O43187 / interleukin 1 receptor associated kinase 2  / reaction / complex
 ENSG00000244687 Q13404 / UBE2V1 / ubiquitin conjugating enzyme E2 V1  / reaction
 ENSG00000177889 UBE2N / P61088 / ubiquitin conjugating enzyme E2 N  / reaction
 ENSG00000172936 MYD88 / Q99836 / myeloid differentiation primary response 88  / complex / reaction






 

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