ENSDARG00000104832


Danio rerio

Features
Gene ID: ENSDARG00000104832
  
Biological name :TLR8
  
Synonyms : TLR8 / toll like receptor 8
  
Possible biological names infered from orthology : P58682 / Q9NR97
  
Species: Danio rerio
  
Chr. number: 9
Strand: 1
Band:
Gene start: 54158387
Gene end: 54163896
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000133386
Ensembl peptide - ENSDARP00000147773
swissprot - A0A0G2KM01
Ensembl - ENSDARG00000104832
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLR8ENSG00000101916Homo sapiens
 Tlr8ENSMUSG00000040522Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tlr7 / toll-like receptor 7 / Q9NYK1*ENSDARG0000006881240
tlr9 / toll-like receptor 9 / Q9NR96* / AC097637.1*ENSDARG0000004449033
tlr8b / toll-like receptor 8b / TLR8* / Q9NR97* / P58682* / toll like receptor 8*ENSDARG0000007367530
tlr3 / toll-like receptor 3 / O15455* / Q99MB1* / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA.*ENSDARG0000001606521
tlr22 / toll-like receptor 22ENSDARG0000010404520
tlr5a / toll-like receptor 5a / TLR5* / O60602* / toll like receptor 5*ENSDARG0000004441519
tlr21 / toll-like receptor 21ENSDARG0000005804519
tlr5b / toll-like receptor 5b / TLR5* / O60602* / toll like receptor 5*ENSDARG0000005232218
tlr2 / toll-like receptor 2 / O60603*ENSDARG0000003775817
tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*ENSDARG0000002204816
tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*ENSDARG0000007567116
tlr18 / toll-like receptor 18ENSDARG0000004024916
tlr19 / toll-like receptor 19 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000007039216
tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*ENSDARG0000001974216
tlr19 / toll-like receptor 19 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000002666315
tlr1 / toll-like receptor 1 / TLR6* / TLR10* / Q15399* / Q9BXR5* / Q9EPQ1* / Q9Y2C9* / toll like receptor 6* / toll like receptor 10*ENSDARG0000010064915
tlr20.2 / tlr20.4 / toll-like receptor 20, tandem duplicate 2 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000008870114
cd180 / CD180 molecule / Q62192* / Q99467* / CD180 antigen *ENSDARG0000009375013
senp7a / SUMO1/sentrin specific peptidase 7a / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000010952211
senp7a / SUMO1/sentrin specific peptidase 7a / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000011513611


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR026906  Leucine rich repeat 5
 IPR027175  Toll-like receptor 8
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034158 toll-like receptor 8 signaling pathway IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045089 positive regulation of innate immune response IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0051607 defense response to virus IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Toll Like Receptor 7/8 (TLR7/8) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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