ENSDARG00000037758


Danio rerio

Features
Gene ID: ENSDARG00000037758
  
Biological name :tlr2
  
Synonyms : tlr2 / toll-like receptor 2
  
Possible biological names infered from orthology : O60603
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 8984068
Gene end: 8988504
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000110559
Ensembl peptide - ENSDARP00000055005
NCBI entrez gene - 403125     See in Manteia.
RefSeq - NM_212812
RefSeq Peptide - NP_997977
swissprot - F1R1U3
swissprot - F1QWS9
ZFIN ID - ZDB-GENE-040219-6
Ensembl - ENSDARG00000037758
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TLR2BENSGALG00000034722Gallus gallus
 TLR2ENSG00000137462Homo sapiens
 Tlr2ENSMUSG00000027995Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tlr1 / toll-like receptor 1 / TLR6* / TLR10* / Q15399* / Q9BXR5* / Q9EPQ1* / Q9Y2C9* / toll like receptor 6* / toll like receptor 10*ENSDARG0000010064928
tlr18 / toll-like receptor 18ENSDARG0000004024928
tlr22 / toll-like receptor 22ENSDARG0000010404523
tlr21 / toll-like receptor 21ENSDARG0000005804522
tlr4bb / toll-like receptor 4b, duplicate b / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*ENSDARG0000002204821
TLR8 / toll like receptor 8 / Q9NR97*ENSDARG0000010483221
tlr7 / toll-like receptor 7 / Q9NYK1*ENSDARG0000006881221
tlr9 / toll-like receptor 9 / Q9NR96* / AC097637.1*ENSDARG0000004449021
tlr4al / toll-like receptor 4a, like / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*ENSDARG0000007567120
tlr4ba / toll-like receptor 4b, duplicate a / TLR4* / Q9QUK6* / O00206* / toll like receptor 4*ENSDARG0000001974220
tlr5a / toll-like receptor 5a / TLR5* / O60602* / toll like receptor 5*ENSDARG0000004441519
tlr5b / toll-like receptor 5b / TLR5* / O60602* / toll like receptor 5*ENSDARG0000005232219
tlr3 / toll-like receptor 3 / O15455* / Q99MB1* / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA.*ENSDARG0000001606519
tlr20.2 / tlr20.4 / toll-like receptor 20, tandem duplicate 2 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000008870118
tlr19 / toll-like receptor 19 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000007039218
tlr19 / toll-like receptor 19 / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000002666316
tlr8b / toll-like receptor 8b / TLR8* / Q9NR97* / P58682* / toll like receptor 8*ENSDARG0000007367515
senp7a / SUMO1/sentrin specific peptidase 7a / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000011513615
senp7a / SUMO1/sentrin specific peptidase 7a / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSDARG0000010952214
cd180 / CD180 molecule / Q62192* / Q99467* / CD180 antigen *ENSDARG0000009375013


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027185  Toll-like receptor 2
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002237 response to molecule of bacterial origin IEA
 biological_processGO:0002253 activation of immune response IMP
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IBA


Pathways (from Reactome)
Pathway description
Regulation of TLR by endogenous ligand
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0001094 whole organism whole organism increased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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