ENSGALG00000016590


Gallus gallus

Features
Gene ID: ENSGALG00000016590
  
Biological name :TLR7
  
Synonyms : TLR7 / toll-like receptor 7
  
Possible biological names infered from orthology : P58681 / Q9NYK1
  
Species: Gallus gallus
  
Chr. number: 1
Strand: -1
Band:
Gene start: 123406951
Gene end: 123414379
  
Corresponding Affymetrix probe sets: GgaAffx.10617.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000035830
Ensembl peptide - ENSGALP00000026726
NCBI entrez gene - 418638     See in Manteia.
RefSeq - XM_015273651
RefSeq - NM_001011688
RefSeq - XM_015273642
RefSeq - XM_015273647
RefSeq Peptide - NP_001011688
swissprot - F1NBN5
swissprot - C4PCM1
Ensembl - ENSGALG00000016590
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr7ENSDARG00000068812Danio rerio
 TLR7ENSG00000196664Homo sapiens
 Tlr7ENSMUSG00000044583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR21 / Toll-like receptor 21 precursor / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSGALG0000003306820
TLR3 / toll-like receptor 3 precursor / Q99MB1* / O15455* / toll like receptor 3* / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA.*ENSGALG0000001346818
TLR4 / toll-like receptor 4 precursor / O00206* / Q9QUK6* / toll like receptor 4*ENSGALG0000000700118
TLR5 / toll-like receptor 5 precursor / O60602* / toll like receptor 5*ENSGALG0000000939218
TLR2B / toll-like receptor 2 type-2 precursor / TLR2* / O60603* / toll like receptor 2*ENSGALG0000003472217
TLR1A / toll-like receptor1 precursor / TLR1* / TLR6* / TLR10* / Q15399* / Q9EPQ1* / Q9BXR5* / Q9Y2C9* / toll like receptor 1* / toll like receptor 6* / toll like receptor 10*ENSGALG0000001748515
TLR15 / Gallus gallus toll-like receptor 15 (TLR15), mRNA.ENSGALG0000000816615
CD180 / CD180 molecule / Q62192* / Q99467* / CD180 antigen *ENSGALG0000002341115
TLR1B / toll-like receptor 6 / TLR1* / TLR6* / TLR10* / Q15399* / Q9Y2C9* / Q9BXR5* / Q9EPQ1* / toll like receptor 1* / toll like receptor 10*ENSGALG0000002709312


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR026880  Toll-like receptor 7
 IPR026906  Leucine rich repeat 5
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001932 regulation of protein phosphorylation IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032757 positive regulation of interleukin-8 production IEA
 biological_processGO:0034154 toll-like receptor 7 signaling pathway IBA
 biological_processGO:0045078 positive regulation of interferon-gamma biosynthetic process IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045356 positive regulation of interferon-alpha biosynthetic process IEA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IEA
 biological_processGO:0045416 positive regulation of interleukin-8 biosynthetic process IEA
 biological_processGO:0051607 defense response to virus IBA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032009 early phagosome IEA
 cellular_componentGO:0043235 receptor complex IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IBA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0035197 siRNA binding IEA


Pathways (from Reactome)
Pathway description
Trafficking and processing of endosomal TLR
Toll Like Receptor 7/8 (TLR7/8) Cascade
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
MyD88 dependent cascade initiated on endosome


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000007932 TRAF6 / TNF receptor associated factor 6 / P70196* / Q9Y4K3*  / complex / reaction
 ENSGALG00000008015 UBE2V1 / ubiquitin-conjugating enzyme E2 variant 1 / Q13404* / ubiquitin conjugating enzyme E2 V1*  / reaction
 ENSGALG00000008407 IRAK2 / interleukin-1 receptor-associated kinase-like 2 / O43187* / Q8CFA1* / interleukin 1 receptor associated kinase 2*  / complex / reaction
 ENSGALG00000016590 TLR7 / toll-like receptor 7 / P58681* / Q9NYK1*  / complex / reaction
 ENSGALG00000028471 CNPY3 / canopy FGF signaling regulator 3 / 3 * / Q9BT09* / Q9DAU1*  / reaction / complex
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / reaction / complex
 ENSGALG00000009586 IRAK4 / interleukin-1 receptor-associated kinase 4 / Q8R4K2* / Q9NWZ3*  / complex / reaction
 ENSGALG00000037716 UBA52 / ubiquitin A-52 residue ribosomal protein fusion product 1 / P62984* / P62987* / Gm5239* / Gm11808* / predicted gene 11808*  / reaction
 ENSGALG00000036790 P79781 / RPS27A / Ubiquitin-40S ribosomal protein S27a Ubiquitin 40S ribosomal protein S27a / P62983* / P62979* / AL136454.1* / ribosomal protein S27a*  / reaction






 

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