ENSGALG00000007001


Gallus gallus

Features
Gene ID: ENSGALG00000007001
  
Biological name :TLR4
  
Synonyms : TLR4 / toll-like receptor 4 precursor
  
Possible biological names infered from orthology : O00206 / Q9QUK6 / toll like receptor 4
  
Species: Gallus gallus
  
Chr. number: 17
Strand: 1
Band:
Gene start: 4083114
Gene end: 4088567
  
Corresponding Affymetrix probe sets: GgaAffx.4379.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000011319
NCBI entrez gene - 417241     See in Manteia.
RefSeq - NM_001030693
RefSeq Peptide - NP_001025864
swissprot - C4PCF3
Ensembl - ENSGALG00000007001
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tlr4alENSDARG00000075671Danio rerio
 tlr4baENSDARG00000019742Danio rerio
 tlr4bbENSDARG00000022048Danio rerio
 TLR4ENSG00000136869Homo sapiens
 Tlr4ENSMUSG00000039005Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TLR7 / toll-like receptor 7 / P58681* / Q9NYK1*ENSGALG0000001659023
TLR21 / Toll-like receptor 21 precursor / Tlr13* / Q6R5N8* / Toll-like receptor 13 *ENSGALG0000003306821
TLR2B / toll-like receptor 2 type-2 precursor / TLR2* / O60603* / toll like receptor 2*ENSGALG0000003472220
TLR3 / toll-like receptor 3 precursor / Q99MB1* / O15455* / toll like receptor 3* / Mus musculus toll-like receptor 3 (Tlr3), transcript variant 3, mRNA.*ENSGALG0000001346819
TLR5 / toll-like receptor 5 precursor / O60602* / toll like receptor 5*ENSGALG0000000939219
TLR1A / toll-like receptor1 precursor / TLR1* / TLR6* / TLR10* / Q15399* / Q9EPQ1* / Q9BXR5* / Q9Y2C9* / toll like receptor 1* / toll like receptor 6* / toll like receptor 10*ENSGALG0000001748518
TLR15 / Gallus gallus toll-like receptor 15 (TLR15), mRNA.ENSGALG0000000816617
CD180 / CD180 molecule / Q62192* / Q99467* / CD180 antigen *ENSGALG0000002341115
TLR1B / toll-like receptor 6 / TLR1* / TLR6* / TLR10* / Q15399* / Q9Y2C9* / Q9BXR5* / Q9EPQ1* / toll like receptor 1* / toll like receptor 10*ENSGALG0000002709314


Protein motifs (from Interpro)
Interpro ID Name
 IPR000157  Toll/interleukin-1 receptor homology (TIR) domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR001611  Leucine-rich repeat
 IPR003591  Leucine-rich repeat, typical subtype
 IPR027168  Toll-like receptor 4
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000187 activation of MAPK activity IEA
 biological_processGO:0002218 activation of innate immune response IEA
 biological_processGO:0002224 toll-like receptor signaling pathway IBA
 biological_processGO:0002322 B cell proliferation involved in immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002537 nitric oxide production involved in inflammatory response IEA
 biological_processGO:0002730 regulation of dendritic cell cytokine production IEA
 biological_processGO:0002755 MyD88-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007252 I-kappaB phosphorylation IEA
 biological_processGO:0009617 response to bacterium IEA
 biological_processGO:0010572 positive regulation of platelet activation IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0014002 astrocyte development IEA
 biological_processGO:0030890 positive regulation of B cell proliferation IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032609 interferon-gamma production IEA
 biological_processGO:0032689 negative regulation of interferon-gamma production IEA
 biological_processGO:0032700 negative regulation of interleukin-17 production IEA
 biological_processGO:0032707 negative regulation of interleukin-23 production IEA
 biological_processGO:0032715 negative regulation of interleukin-6 production IEA
 biological_processGO:0032720 negative regulation of tumor necrosis factor production IEA
 biological_processGO:0032722 positive regulation of chemokine production IEA
 biological_processGO:0032727 positive regulation of interferon-alpha production IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032732 positive regulation of interleukin-1 production IEA
 biological_processGO:0032733 positive regulation of interleukin-10 production IEA
 biological_processGO:0032735 positive regulation of interleukin-12 production IEA
 biological_processGO:0032755 positive regulation of interleukin-6 production IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032874 positive regulation of stress-activated MAPK cascade IEA
 biological_processGO:0034142 toll-like receptor 4 signaling pathway IEA
 biological_processGO:0035666 TRIF-dependent toll-like receptor signaling pathway IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IEA
 biological_processGO:0045359 positive regulation of interferon-beta biosynthetic process IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050671 positive regulation of lymphocyte proliferation IEA
 biological_processGO:0050702 interleukin-1 beta secretion IEA
 biological_processGO:0050707 regulation of cytokine secretion IEA
 biological_processGO:0050727 regulation of inflammatory response IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IBA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0060729 intestinal epithelial structure maintenance IEA
 biological_processGO:0060907 positive regulation of macrophage cytokine production IEA
 biological_processGO:0070373 negative regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070430 positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IEA
 biological_processGO:0070434 positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071223 cellular response to lipoteichoic acid IEA
 biological_processGO:0140052 cellular response to oxidised low-density lipoprotein particle stimulus IEA
 biological_processGO:1900017 positive regulation of cytokine production involved in inflammatory response IEA
 biological_processGO:1900227 positive regulation of NLRP3 inflammasome complex assembly IEA
 biological_processGO:1903223 positive regulation of oxidative stress-induced neuron death IEA
 biological_processGO:1903428 positive regulation of reactive oxygen species biosynthetic process IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0046696 lipopolysaccharide receptor complex IEA
 molecular_functionGO:0001875 lipopolysaccharide receptor activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA


Pathways (from Reactome)
Pathway description
via Death Receptors in the presence of ligand
Toll Like Receptor 4 (TLR4) Cascade
MyD88-independent TLR4 cascade
TRIF-mediated programmed cell death
Regulation of TLR by endogenous ligand
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IKK complex recruitment mediated by RIP1
TRAF6-mediated induction of TAK1 complex within TLR4 complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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