ENSMUSG00000022504


Mus musculus

Features
Gene ID: ENSMUSG00000022504
  
Biological name :Ciita
  
Synonyms : Ciita / MHC class II transactivator / P79621
  
Possible biological names infered from orthology : class II major histocompatibility complex transactivator / P33076
  
Species: Mus musculus
  
Chr. number: 16
Strand: 1
Band: A1
Gene start: 10480059
Gene end: 10528418
  
Corresponding Affymetrix probe sets: 10433507 (MoGene1.0st)   1421210_at (Mouse Genome 430 2.0 Array)   1421211_a_at (Mouse Genome 430 2.0 Array)   1447075_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023147
Ensembl peptide - ENSMUSP00000154946
Ensembl peptide - ENSMUSP00000155002
Ensembl peptide - ENSMUSP00000155232
Ensembl peptide - ENSMUSP00000155517
Ensembl peptide - ENSMUSP00000155635
NCBI entrez gene - 12265     See in Manteia.
MGI - MGI:108445
RefSeq - XM_011245810
RefSeq - NM_001243760
RefSeq - NM_001243761
RefSeq - NM_001302618
RefSeq - NM_001302619
RefSeq - NM_007575
RefSeq - XM_006521724
RefSeq - XM_006521725
RefSeq - XM_006521726
RefSeq Peptide - NP_001230689
RefSeq Peptide - NP_001289547
RefSeq Peptide - NP_001289548
RefSeq Peptide - NP_031601
RefSeq Peptide - NP_001230690
swissprot - P79621
swissprot - Q3U5G4
Ensembl - ENSMUSG00000022504
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ciitaENSDARG00000090851Danio rerio
 CIITAENSGALG00000007171Gallus gallus
 CIITAENSG00000179583Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nlrc5 / C3VPR6 / Protein NLRC5 / Q86WI3* / NLR family CARD domain containing 5*ENSMUSG0000007415121
Nod2 / Q8K3Z0 / Nucleotide-binding oligomerization domain-containing protein 2 / Q9HC29* / nucleotide binding oligomerization domain containing 2*ENSMUSG0000005599415
Nod1 / Q8BHB0 / Nucleotide-binding oligomerization domain-containing protein 1 / Q9Y239* / nucleotide binding oligomerization domain containing 1*ENSMUSG0000003805815
Nlrc3 / Q5DU56 / Protein NLRC3 / Q7RTR2* / NLR family CARD domain containing 3*ENSMUSG0000004987114
Nlrx1 / Q3TL44 / NLR family member X1 / Q86UT6*ENSMUSG0000003210913


Protein motifs (from Interpro)
Interpro ID Name
 IPR001611  Leucine-rich repeat
 IPR007111  NACHT nucleoside triphosphatase
 IPR008095  MHC class II transactivator
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0034341 response to interferon-gamma ISO
 biological_processGO:0045345 positive regulation of MHC class I biosynthetic process ISO
 biological_processGO:0045348 positive regulation of MHC class II biosynthetic process IEA
 biological_processGO:0045892 negative regulation of transcription, DNA-templated ISO
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046677 response to antibiotic ISO
 biological_processGO:0071257 cellular response to electrical stimulus IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071360 cellular response to exogenous dsRNA IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016605 PML body ISS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0008022 protein C-terminus binding ISO
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0033613 activating transcription factor binding ISO
 molecular_functionGO:0044212 transcription regulatory region DNA binding ISO
 molecular_functionGO:0044877 protein-containing complex binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000066 osteoporosis "reduction in bone mass or atrophy of skeletal tissue; may lead to skeletal fragility" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0000188 abnormal circulating glucose level "anomalous concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pkd1tm2Jzh/Pkd1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Elovl4tm1Rayy/Elovl4+
Genetic Background: involves: 129 * C57BL/6J

Allelic Composition: Ciitatm1Adm/Ciita+
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0001793 altered susceptibility to infection "a change in the likelihood that an organism will develop ill effects from a pathogenic invasion or from components of or toxins produced by pathogens " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Otcspf-ash/Y
Genetic Background: B6EiC3Sn a/A-Otcspf-ash/J

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Pkd1tm2Jzh/Pkd1+
Genetic Background: either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6)

 MP:0001869 pancreas inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the pancreas " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.129S2(B6)-Ciitatm1Ccum

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.Cg-B2mtm1Unc Ciitatm1Ccum

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.129S2(B6)-Ciitatm1Ccum

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Rfngtm2.1Tfv/Rfngtm2.1Tfv
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac

 MP:0002352 abnormal popliteal lymph node morphology "anomalous structure, development, or number of the lymph nodes which drain the legs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Fgf4tm1Bas/Fgf4tm1Bas
Genetic Background: involves: 129S6/SvEvTac

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Otcspf-ash/Y
Genetic Background: B6EiC3Sn a/A-Otcspf-ash/J

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0003790 absent CD4+8- cells "lack of the set of single-positive T cells that express CD4 on their surface" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Otcspf-ash/Y
Genetic Background: B6EiC3Sn a/A-Otcspf-ash/J

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0004031 insulitis "a histologic change in the islets of Langerhans characterized by edema and the infiltration of small numbers of white blood cells" [rbabiuk:Randall Babiuk, Mouse Genome Informatics Curator]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.129S2(B6)-Ciitatm1Ccum

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Vdrtm1Rge/Vdrtm1Rge
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004804 decreased susceptibility to autoimmune diabetes "reduced likelihood that an organism will develop inflammatory pancreatic disease resulting from the body attacking and destroying the insulin-producing beta islet cells of the pancreas" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.129S2(B6)-Ciitatm1Ccum

Allelic Composition: B2mtm1Unc/B2mtm1Unc,Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.Cg-B2mtm1Unc Ciitatm1Ccum

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0004992 increased bone resorption "greater than average amount of degradation of the organic and inorganic phases of bone by absorption, usually by the abnormal function or number of osteoclasts" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0005026 decreased susceptibility to parasitic infection "reduced likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0005040 abnormal MHC II cell surface expression on macrophages "anomaly in the ability of macrophages to express major histocompatibility complex class II at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:31326]
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0005042 abnormal level of surface class II molecules "deviation from the normal concentration of major histocompatibility complex class II molecules expressed at the cell surface" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.129S2(B6)-Ciitatm1Ccum

Allelic Composition: Ciitatm1.1Dim/Ciitatm1.1Dim
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0005091 increased double-positive T cell count "greater than the expected number of the subset of T cells found in the thymus that express both CD4 and CD8" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Otcspf-ash/Y
Genetic Background: B6EiC3Sn a/A-Otcspf-ash/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0005463 abnormal CD4+ T cell physiology "anomalous response of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0005465 abnormal T helper 1 physiology "anomalous response of the subset of helper T cells that enhance cell-mediated immune responses; these cells secrete IL-1 and gamma-IFN and are generally involved in inflammatory responses" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Vdrtm1Rge/Vdrtm1Rge
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005580 periinsulitis "early pancreatic infiltration of mononuclear cells around pancreatic Langerhans islets" [J:11442, il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.129S2(B6)-Ciitatm1Ccum

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pkd1tm1Ggg/Pkd1tm1Ggg
Genetic Background: either: (involves: 129/Sv) or (involves: 129/Sv * Black Swiss)

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fgf4tm1Bas/Fgf4tm1Bas
Genetic Background: involves: 129S6/SvEvTac

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.129S2(B6)-Ciitatm1Ccum

Allelic Composition: Ciitatm1.1Dim/Ciitatm1.1Dim
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

Allelic Composition: Ciitatm1Jpyt/Ciitatm1Jpyt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008076 abnormal CD4-positive T cell differentiation "atypical production of or inability to produce the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Socs2m1Btlr/Socs2m1Btlr
Genetic Background: C57BL/6J-Socs2m1Btlr

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: involves: 129S2/SvPas * C57BL/6J

Allelic Composition: Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.129S2(B6)-Ciitatm1Ccum

Allelic Composition: Ciitatm1Jpyt/Ciitatm1Jpyt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008080 abnormal CD8-positive T cell differentiation "atypical production of or inability to produce the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Socs2m1Btlr/Socs2m1Btlr
Genetic Background: C57BL/6J-Socs2m1Btlr

 MP:0008083 decreased single-positive T cell number "reduced number of T cells bearing either CD4 or CD8 markers on their surface" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: B2mtm1Unc/B2mtm1Unc,Ciitatm1Ccum/Ciitatm1Ccum
Genetic Background: NOD.Cg-B2mtm1Unc Ciitatm1Ccum

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ciitatm1.1Dim/Ciitatm1.1Dim
Genetic Background: involves: 129S2/SvPas * C57BL/6 * SJL

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0010879 decreased trabecular bone volume "decrease in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0013630 increased bone trabecular spacing "increase in the amount of space between trabeculae in cancellous bone" [MGI:jwhite]
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Allelic Composition: Atp1b1tm1.1Zboro/Atp1b1tm1.1Zboro,Tg(Sftpc-cre)1Blh/0
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * DBA/2

 MP:0020154 impaired humoral immune response "impaired response of the immune system that mediates secreted antibodies produced in B cells" [GOC:NV]
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Allelic Composition: Socs2m1Btlr/Socs2m1Btlr
Genetic Background: C57BL/6J-Socs2m1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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