ENSMUSG00000037523


Mus musculus

Features
Gene ID: ENSMUSG00000037523
  
Biological name :Mavs
  
Synonyms : Mavs / Mitochondrial antiviral-signaling protein / Q8VCF0
  
Possible biological names infered from orthology : Q7Z434
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: F1
Gene start: 131234063
Gene end: 131248025
  
Corresponding Affymetrix probe sets: 10476276 (MoGene1.0st)   1439185_x_at (Mouse Genome 430 2.0 Array)   1451176_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038339
Ensembl peptide - ENSMUSP00000105828
Ensembl peptide - ENSMUSP00000138401
NCBI entrez gene - 228607     See in Manteia.
MGI - MGI:2444773
RefSeq - NM_001206385
RefSeq - NM_001206382
RefSeq - NM_001206383
RefSeq - NM_144888
RefSeq Peptide - NP_001193311
RefSeq Peptide - NP_001193312
RefSeq Peptide - NP_001193314
RefSeq Peptide - NP_659137
swissprot - Q8VCF0
swissprot - S4R1W6
Ensembl - ENSMUSG00000037523
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mavsENSDARG00000069733Danio rerio
 MAVSENSGALG00000040428Gallus gallus
 MAVSENSG00000088888Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR026148  Mitochondrial antiviral-signalling protein
 IPR031964  Caspase recruitment domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001934 positive regulation of protein phosphorylation ISO
 biological_processGO:0002218 activation of innate immune response ISO
 biological_processGO:0002230 positive regulation of defense response to virus by host ISO
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007165 signal transduction ISO
 biological_processGO:0032481 positive regulation of type I interferon production IMP
 biological_processGO:0032727 positive regulation of interferon-alpha production ISO
 biological_processGO:0032728 positive regulation of interferon-beta production ISS
 biological_processGO:0032757 positive regulation of interleukin-8 production ISO
 biological_processGO:0032760 positive regulation of tumor necrosis factor production ISO
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation ISO
 biological_processGO:0035549 positive regulation of interferon-beta secretion ISO
 biological_processGO:0039529 RIG-I signaling pathway IGI
 biological_processGO:0042742 defense response to bacterium ISO
 biological_processGO:0042993 obsolete positive regulation of transcription factor import into nucleus ISO
 biological_processGO:0045071 negative regulation of viral genome replication IMP
 biological_processGO:0045087 innate immune response ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity ISO
 biological_processGO:0051607 defense response to virus ISO
 biological_processGO:0060340 positive regulation of type I interferon-mediated signaling pathway ISO
 biological_processGO:0060760 positive regulation of response to cytokine stimulus ISS
 biological_processGO:0071360 cellular response to exogenous dsRNA ISS
 biological_processGO:0071651 positive regulation of chemokine (C-C motif) ligand 5 production ISO
 biological_processGO:0071660 positive regulation of IP-10 production ISO
 biological_processGO:1900063 regulation of peroxisome organization IMP
 biological_processGO:1902741 positive regulation of interferon-alpha secretion ISO
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion ISO
 biological_processGO:2000778 positive regulation of interleukin-6 secretion ISO
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005741 mitochondrial outer membrane TAS
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005778 peroxisomal membrane ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031966 mitochondrial membrane IBA
 molecular_functionGO:0004871 obsolete signal transducer activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0050700 CARD domain binding ISO


Pathways (from Reactome)
Pathway description
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001805 decreased IgG "less than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001846 increased inflammatory response "greater than expected response to injury, infection, or insult " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001847 brain inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Atg16l1Gt(BC0122)Wtsi/Atg16l1Gt(BC0122)Wtsi,Tg(CAG-EGFP/Map1lc3b)53Nmz/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6NCrj

 MP:0001856 myocarditis "inflammation of the heart walls" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001873 stomach inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the stomach" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
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Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mavstm1Zjc/Mavs+
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002419 abnormal innate immunity "anomaly in the function of the early phase of the response to infection; normally, it is present at all times, does not increase with exposure to specific pathogens, and does not discriminate between pathogens" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mavstm1Zjc/Mavs+
Genetic Background: involves: 129/Sv * C57BL/6

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ifna6tm1Aki/Ifna6+,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hrh2tm1Yfks/Hrh2tm1Yfks
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd207tm2.1(cre)Bjec/Cd207+,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002494 increased IgM "greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ifih1Rgsc422/Ifih1+
Genetic Background: D2JJcl.B6JJcl-Ifih1Rgsc422

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004510 myositis "inflammation of skeletal muscle; local accumulation of fluid, plasma proteins, and leukocytes in the striated muscle" [MESH:C05.651.594]
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Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mavstm1Itl/Mavstm1Itl,Trex1tm1Tld/Trex1tm1Tld
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

 MP:0005079 defective cytotoxic T cell cytolysis "impaired ability of these cells to destroy or dissolve targeted cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:6692]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

 MP:0005093 impaired B cell proliferation "absent or reduced ability of B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cd207tm2.1(cre)Bjec/Cd207+,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006173 abnormal Langerhans cell morphology/development "anomaly in the formation or structure of phagocytic dendritic cells principally found in the epidemis and mucosal epithelium" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95147]
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Allelic Composition: Ifna6tm1Aki/Ifna6+,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
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Allelic Composition: Ifna6tm1Aki/Ifna6+,Myd88tm1Aki/Myd88tm1Aki
Genetic Background: involves: 129P2/OlaHsd

 MP:0008495 decreased IgG1 level "less than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008496 decreased IgG2a level "less than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008548 abnormal circulating interferon level "anomaly in the amount in the blood of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008557 abnormal interferon-alpha secretion "anomaly in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Ticam1tm1Tsse/Ticam1tm1Tsse,Tg(PVR)1Kkst/0
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0008561 decreased tumor necrosis factor secretion "reduction in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Cd207tm2.1(cre)Bjec/Cd207+,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008563 decreased interferon-alpha secretion "increase in the production or release of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ifna6tm1Aki/Ifna6+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008565 decreased interferon-beta secretion "reduction in the production or release of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Tsc/Mavstm1Tsc
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008574 decreased circulating interferon-alpha level "reduction in the amount in the blood of one of the type I interferons produced by peripheral blood leukocytes or lymphoblastoid cells that has antiviral activity and activates natural killer cells and B cells" [MESH:D12.644.276.374.440.890.250]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008576 decreased circulating interferon-beta level "reduction in the amount in the blood of one of the type I interferons produced by fibroblasts in response to stimulation by live or inactivated virus or by double-stranded RNA with antiviral, antiproliferative, and immunomodulating activity" [MESH:D12.644.276.374.440.890.275]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008596 increased circulating interleukin-6 level "increase in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008597 decreased circulating interleukin-6 level "reduction in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008648 decreased circulating interleukin-12b level "reduction in the amount in the blood of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008664 decreased interleukin-12 secretion "reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]
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Allelic Composition: Cd207tm2.1(cre)Bjec/Cd207+,Tgfbr1tm1.1Karl/Tgfbr1tm1.1Karl
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki,Ticam1tm1Aki/Ticam1tm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: Not Specified

 MP:0009790 decreased susceptibility to viral infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ticam1tm1Tsse/Ticam1tm1Tsse,Tg(PVR)1Kkst/0
Genetic Background: involves: 129 * C57BL/6 * ICR

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Mavstm1Aki/Mavstm1Aki
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Ddx60tm1b(EUCOMM)Wtsi/Ddx60tm1b(EUCOMM)Wtsi,Mavstm1Tsse/Mavstm1Tsse
Genetic Background: involves: 129 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032109 Nlrx1 / Q3TL44 / NLR family member X1 / Q86UT6*  / reaction / complex
 ENSMUSG00000038160 Atg5 / Q99J83 / Autophagy protein 5 / Q9H1Y0* / autophagy related 5*  / complex
 ENSMUSG00000040296 Ddx58 / Q6Q899 / Probable ATP-dependent RNA helicase DDX58 / O95786* / DExD/H-box helicase 58*  / complex / reaction
 ENSMUSG00000032905 Atg12 / Q9CQY1 / Ubiquitin-like protein ATG12 / O94817* / autophagy related 12*  / complex






 

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