ENSMUSG00000038160


Mus musculus

Features
Gene ID: ENSMUSG00000038160
  
Biological name :Atg5
  
Synonyms : Atg5 / Autophagy protein 5 / Q99J83
  
Possible biological names infered from orthology : autophagy related 5 / Q9H1Y0
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: B2
Gene start: 44268358
Gene end: 44364291
  
Corresponding Affymetrix probe sets: 10362922 (MoGene1.0st)   10338565 (MoGene1.0st)   10338984 (MoGene1.0st)   10339127 (MoGene1.0st)   10339247 (MoGene1.0st)   10339889 (MoGene1.0st)   10340291 (MoGene1.0st)   10341553 (MoGene1.0st)   10342288 (MoGene1.0st)   10342567 (MoGene1.0st)   10343205 (MoGene1.0st)   10343908 (MoGene1.0st)   10344127 (MoGene1.0st)   10338268 (MoGene1.0st)   10338401 (MoGene1.0st)   10340175 (MoGene1.0st)   10340552 (MoGene1.0st)   10340657 (MoGene1.0st)   10341676 (MoGene1.0st)   10342184 (MoGene1.0st)   10342257 (MoGene1.0st)   1415684_at (Mouse Genome 430 2.0 Array)   1418235_at (Mouse Genome 430 2.0 Array)   1418236_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000044769
NCBI entrez gene - 11793     See in Manteia.
MGI - MGI:1277186
RefSeq - XM_017313783
RefSeq - NM_001314013
RefSeq - NM_053069
RefSeq - XM_011243108
RefSeq - XM_017313782
RefSeq Peptide - NP_001300942
RefSeq Peptide - NP_444299
swissprot - Q99J83
Ensembl - ENSMUSG00000038160
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 atg5ENSDARG00000023396Danio rerio
 ATG5ENSGALG00000015387Gallus gallus
 ATG5ENSG00000057663Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007239  Autophagy-related protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0000422 autophagy of mitochondrion IMP
 biological_processGO:0001974 blood vessel remodeling IMP
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002739 regulation of cytokine secretion involved in immune response IMP
 biological_processGO:0006914 autophagy ISO
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0009267 cellular response to starvation IMP
 biological_processGO:0009620 response to fungus IMP
 biological_processGO:0016236 macroautophagy IMP
 biological_processGO:0019725 cellular homeostasis IMP
 biological_processGO:0019883 antigen processing and presentation of endogenous antigen IMP
 biological_processGO:0031397 negative regulation of protein ubiquitination IMP
 biological_processGO:0035973 aggrephagy IMP
 biological_processGO:0039689 negative stranded viral RNA replication IMP
 biological_processGO:0042311 vasodilation IMP
 biological_processGO:0042493 response to drug IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043687 post-translational protein modification IDA
 biological_processGO:0044804 autophagy of nucleus IBA
 biological_processGO:0045060 negative thymic T cell selection IMP
 biological_processGO:0048840 otolith development IMP
 biological_processGO:0050765 negative regulation of phagocytosis IMP
 biological_processGO:0051279 regulation of release of sequestered calcium ion into cytosol IMP
 biological_processGO:0055015 ventricular cardiac muscle cell development IMP
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061739 protein lipidation involved in autophagosome assembly IMP
 biological_processGO:0070257 positive regulation of mucus secretion IMP
 biological_processGO:0071500 cellular response to nitrosative stress IMP
 biological_processGO:0075044 autophagy of host cells involved in interaction with symbiont IEA
 biological_processGO:1902017 regulation of cilium assembly IMP
 biological_processGO:2000377 regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000378 negative regulation of reactive oxygen species metabolic process IMP
 biological_processGO:2000619 negative regulation of histone H4-K16 acetylation IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005776 autophagosome IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0034045 phagophore assembly site membrane IEA
 cellular_componentGO:0034274 Atg12-Atg5-Atg16 complex IBA
 cellular_componentGO:0044233 ER-mitochondrion membrane contact site IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019776 Atg8 ligase activity IBA


Pathways (from Reactome)
Pathway description
Macroautophagy
Pink/Parkin Mediated Mitophagy
Receptor Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000598 abnormal liver morphology "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(CAG-cre)13Miya/?
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000639 abnormal adrenal gland morphology "malformed endocrine glands located above the kidney responsible for hormone and epinephrine secretion" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:61190]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0000703 abnormal thymus morphology "anomalous structure or development of the primary lymphoid organ; required for immune system development" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:55400]
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Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0000745 tremors "repetitive, cyclical movements of the body or a body part; usually involuntary, but can also manifest in response to an attempt at movement" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000776 abnormal inferior colliculus "dysmorphology or disorganization of the paired inferior eminence of the mesencephalic tectum that is involved in preliminary visual processing, and control of eye movements" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000832 abnormal thalamus morphology "malformation or absence of the large ovoid mass of paired bodies containing mostly gray matter and forming part of the lateral wall of the third ventricle of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0000876 Purkinje cell degeneration "a retrogressive impairment of function or destruction of the large neurons located at the interface of the molecular and internal granule layers of the cerebellar cortex" [J:46854]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
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Allelic Composition: Pik3c3tm1Tssk/Pik3c3tm1Tssk,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: FVB/N

 MP:0001393 ataxia "inability to coordinate voluntary muscular movements" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:67231]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001407 short stride length "reduced average distance between steps" [J:34193]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001436 abnormal suckling behavior "reduced ability or inability to exert suction by the mouth, or atypical suckling pattern" [J:16461]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001513 limb grasping "mice clasp front and/or hind feet almost immediately upon being lifted by tail" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0001759 increased urine glucose level "a greater level of excretion of glucose in the urine compared to the normal state" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Itgavtm2.1Hyn/Itgavtm2.1Hyn
Genetic Background: involves: 129P2/OlaHsd

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Mx1-cre)1Cgn/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Smarcb1tm1Mya/Smarcb1tm1Mya
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Myh6-cre)2182Mds/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0002371 abnormal thymus cortex morphology "anomalous structure or development of the outer area of thymus lobules" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(CAG-EGFP/Map1lc3b)53Nmz/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0002753 dilated left ventricle "an expansion in the volume of the lower left chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002833 increased heart weight "greater than average weight of the heart compared to the average for a particular strain" [RGD:Rat Genome Database submission]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

 MP:0002840 abnormal lens fibers morphology "structural anomaly of the elongated cells of the crystalline lens of the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Pik3c3tm1Tssk/Pik3c3tm1Tssk,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: FVB/N

 MP:0002972 abnormal cardiac muscle contractility "altered ability of the heart muscle to shorten or to develop increased tension, often measured by dP/dT max" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0002978 absent otoliths "absence of the crystalline calciferous particles adhering to the otolithic membrane" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003143 enlarged otoliths "increased average size of the crystalline calciferous particles adhering to the otolithic membrane" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:67072]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

 MP:0003311 aminoaciduria "excretion of amino acids in the urine, especially in excessive amounts" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:66560]
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Allelic Composition: Itgavtm2.1Hyn/Itgavtm2.1Hyn
Genetic Background: involves: 129P2/OlaHsd

 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Dcbld2tm1Mhms/Dcbld2tm1.1Mhms,Tg(Cdh5-cre)7Mlia/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N

 MP:0003674 oxidative stress "condition characterized by an accumulation of free radical groups in the body, which creates a potentially unstable and damaging cellular environment linked to tissue damage, accelerated aging, and degenerative disease; can result from many factors, including exposure to alcohol, medications, poor nutrition, trauma, cold or toxins; may be indicated by low antioxidant levels measured in blood plasma" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0003763 abnormal thymus physiology "anomalous function of the primary lymphoid organ that is required for immune system development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0003897 abnormal ST interval "anomaly in the time between the end of S-wave and the beginning of T-wave" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9+,Hoxb9tm1Mrc/Hoxb9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0003917 increased kidney weight "greater heft of the organs responsible for urine secretion" [RGD:Rat Genome Database submission]
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Allelic Composition: Itgavtm2.1Hyn/Itgavtm2.1Hyn
Genetic Background: involves: 129P2/OlaHsd

 MP:0003944 abnormal T cell subpopulation ratio "deviation from the standard ratios of T cell subpopulations (e.g. double positive to single positive ratio) compared to control samples" [mberry:Melissa Berry, Genetics Resources Curator]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0004098 abnormal granule neuron "any structural anomaly of the small neurons of the granule cell layer that send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0004163 abnormal adenophysis morphology "any malformation or absence of the anterior part of the pituitary that secretes a variety of hormones; its function is regulated by the hypothalamus" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004191 neuronal intranuclear inclusions "presence of aggregates of protein within the nuclei of neurons; frequently seen in Huntington s disease" [acv:Alicia Valenzuela_Genetic Resources Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0004564 enlarged myocardial fiber "increased size of cardiac muscle fibers, the multinucleated muscle cells of the heart" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0004756 abnormal proximal convoluted tubule morphology "any structural anomaly of the convoluted portion of the duct system of the nephron that extends from the renal glomeurlar capsule in the kidney cortex into the kidney medulla where it joins the loop of Henle; fluid entering the proximal convoluted tubule is reabsorbed into the peritubular capillaries, including approximately two-thirds of the filtered salt and water and all filtered organic solutes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgavtm2.1Hyn/Itgavtm2.1Hyn
Genetic Background: involves: 129P2/OlaHsd

 MP:0004843 abnormal Paneth cell morphology "any structural anomaly of the large secretory cells containing coarse granules found at the base of the crypts of Lieberkuhn in the small intestine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg16l1Gt(XR0164)Wtsi/Atg16l1Gt(XR0164)Wtsi
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005058 abnormal lysosome morphology "anomalous structure of any of the cytoplasmic, membrane bound vesicles that contain a variety of hydrolases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9+,Hoxb9tm1Mrc/Hoxb9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

 MP:0005311 abnormal circulating amino acid level "aberrant concentration in the blood of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:83263]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9+,Hoxb9tm1Mrc/Hoxb9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9+,Hoxb9tm1Mrc/Hoxb9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0005404 abnormal axon morphology "anomaly in the structure of the single process of a nerve cell that normally conducts impulses away from the cell body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Atg5tm1.1Myok/Atg5tm1.1Myok,Col1a1tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/Col1a1+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

 MP:0005630 increased lung weight "greater than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,A1cfTg(Myh6-cre/Esr1*)1Jmk/?
Genetic Background: involves: 129S/SvEv * FVB/N

 MP:0006090 abnormal utricle morphology "malformation in the larger of the two sacs in the vestibule" [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99, J:92940]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0008037 abnormal T cell morphology "any structural anomaly of lymphocytes that are responsible for cell-mediated immunity and immune system regulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008079 decreased CD8-positive T cell number "reduction in the number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Prdm13tm1.1Tfur/Prdm13tm1.1Tfur,Tg(Dkk3-cre)D9Tfur/0
Genetic Background: involves: C3H * C57BL/6 * C57BL/6J * C57BL/6N

 MP:0008260 abnormal autophagy "abnormal catabolic process involving the degradation of a cell s own components through the lysosomal machinery" [MGI:honda "Hiraoki Onda, Mouse Genome Informatics Curator"]
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Allelic Composition: Artm4(AR)Dmr/Ar+
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Vil1-cre)997Gum/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Kap-cre)1Isa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(CAG-EGFP/Map1lc3b)53Nmz/0,Tg(Cryaa-cre)10Mlr/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA/2 * FVB/N

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(BEST1-cre)1Taf/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Pomc1-cre)1Gsb/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Cnot3tm1.1Kjkb/Cnot3tm1.1Kjkb,Tg(Ckmm-cre)5Khn/0
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6 * FVB

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0009546 absent gastric milk in neonates "failure of nursing offspring to ingest milk as indicated by stomach content" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9+,Hoxb9tm1Mrc/Hoxb9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S/SvEv * 129S4/SvJae

 MP:0009974 decreased cerebral cortex pyramidal cell number "reduced number of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Nes-cre)1Kln/?
Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Rhebtm1.1Otsu/Rhebtm1.1Otsu,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129S/SvEv * C57BL/6J * FVB/N

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Hoxa9tm1Mrc/Hoxa9+,Hoxb9tm1Mrc/Hoxb9tm1Mrc
Genetic Background: involves: 129S7/SvEvBrd

Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(CAG-EGFP/Map1lc3b)53Nmz/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011630 increased mitochondria size "enlarged the cellular organelles responsible for energy production" [MGI:csmith]
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Allelic Composition: Atg5tm1Nmz/Atg5tm1Nmz,Tg(Cd4-cre)1Cwi/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(BEST1-cre)1Taf/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(BEST1-cre)1Taf/0
Genetic Background: involves: 129S/SvEv * C57BL/6J

 MP:0020406 hyperthreoninuria "excretion of excessive amounts of threonine in the urine" [HP:0003296]
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Allelic Composition: Atg5tm1Myok/Atg5tm1Myok,Tg(Kap-cre)1Isa/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000026289 Q8C0J2 / Atg16l1 / autophagy related 16-like 1 (S. cerevisiae) / Q676U5* / autophagy related 16 like 1*  / reaction / complex
 ENSMUSG00000021619 Atg10 / autophagy related 10 / Q9H0Y0*  / complex / reaction
 ENSMUSG00000025040 Fundc1 / Q9DB70 / FUN14 domain-containing protein 1 / Q8IVP5* / FUN14 domain containing 1*  / complex / reaction
 ENSMUSG00000038160 Atg5 / Q99J83 / Autophagy protein 5 / Q9H1Y0* / autophagy related 5*  / complex / reaction
 ENSMUSG00000029578 Wipi2 / Q80W47 / WD repeat domain, phosphoinositide interacting 2 / Q9Y4P8*  / complex / reaction
 ENSMUSG00000032905 Atg12 / Q9CQY1 / Ubiquitin-like protein ATG12 / O94817* / autophagy related 12*  / complex / reaction
 ENSMUSG00000037523 Mavs / Q8VCF0 / Mitochondrial antiviral-signaling protein / Q7Z434*  / complex
 ENSMUSG00000040296 Ddx58 / Q6Q899 / Probable ATP-dependent RNA helicase DDX58 / O95786* / DExD/H-box helicase 58*  / reaction / complex
 ENSMUSG00000031812 Q9CQV6 / Map1lc3b / Microtubule-associated proteins 1A/1B light chain 3B / A6NCE7* / Q9GZQ8* / MAP1LC3B2* / microtubule associated protein 1 light chain 3 beta* / microtubule associated pr...  / reaction / complex
 ENSMUSG00000027602 Q91VR7 / Map1lc3a / Microtubule-associated proteins 1A/1B light chain 3A / Q9H492* / microtubule associated protein 1 light chain 3 alpha*  / complex / reaction






 

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