ENSMUSG00000031812


Mus musculus

Features
Gene ID: ENSMUSG00000031812
  
Biological name :Map1lc3b
  
Synonyms : Map1lc3b / Microtubule-associated proteins 1A/1B light chain 3B / Q9CQV6
  
Possible biological names infered from orthology : A6NCE7 / MAP1LC3B2 / microtubule associated protein 1 light chain 3 beta / microtubule associated protein 1 light chain 3 beta 2 / Q9GZQ8
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: E1
Gene start: 121590361
Gene end: 121598760
  
Corresponding Affymetrix probe sets: 10419354 (MoGene1.0st)   10576056 (MoGene1.0st)   1415928_a_at (Mouse Genome 430 2.0 Array)   1415929_at (Mouse Genome 430 2.0 Array)   1415930_a_at (Mouse Genome 430 2.0 Array)   1428024_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137754
Ensembl peptide - ENSMUSP00000137996
Ensembl peptide - ENSMUSP00000148359
Ensembl peptide - ENSMUSP00000034270
NCBI entrez gene - 67443     See in Manteia.
MGI - MGI:1914693
RefSeq - NM_026160
RefSeq Peptide - NP_080436
swissprot - Q9CQV6
swissprot - A0A1D5RLG5
swissprot - M0QWC2
swissprot - M0QWT8
Ensembl - ENSMUSG00000031812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map1lc3bENSDARG00000101127Danio rerio
 MAP1LC3BENSGALG00000043105Gallus gallus
 A6NCE7ENSG00000258102Homo sapiens
 Q9GZQ8ENSG00000140941Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q91VR7 / Map1lc3a / Microtubule-associated proteins 1A/1B light chain 3A / Q9H492* / microtubule associated protein 1 light chain 3 alpha*ENSMUSG0000002760279
P60521 / Gabarapl2 / Gamma-aminobutyric acid receptor-associated protein-like 2 / P60520* / GABA type A receptor associated protein like 2*ENSMUSG0000003195036
Q9DCD6 / Gabarap / Gamma-aminobutyric acid receptor-associated protein / O95166* / GABA type A receptor-associated protein*ENSMUSG0000001856730
Q8R3R8 / Gabarapl1 / Gamma-aminobutyric acid receptor-associated protein-like 1 / Q9H0R8* / GABA type A receptor associated protein like 1*ENSMUSG0000003016130


Protein motifs (from Interpro)
Interpro ID Name
 IPR004241  Autophagy protein Atg8 ubiquitin-like
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IBA
 biological_processGO:0000422 autophagy of mitochondrion ISO
 biological_processGO:0006914 autophagy IEA
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0009267 cellular response to starvation ISO
 biological_processGO:0016236 macroautophagy ISO
 biological_processGO:0070257 positive regulation of mucus secretion IMP
 biological_processGO:0097352 autophagosome maturation ISO
 cellular_componentGO:0000421 autophagosome membrane IBA
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005776 autophagosome ISO
 cellular_componentGO:0005829 cytosol IBA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005874 microtubule IEA
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0012505 endomembrane system IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0044754 autolysosome IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO


Pathways (from Reactome)
Pathway description
Macroautophagy
Pink/Parkin Mediated Mitophagy
TBC/RABGAPs
Receptor Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003449 abnormal intestinal goblet cells "malformation of the unicellular mucin-secreting glands" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95282]
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Allelic Composition: Nek8jck/Nek8+,Pkd1tm1Bdgz/Pkd1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Nek8jck/Nek8+,Pkd1tm1Bdgz/Pkd1+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032905 Atg12 / Q9CQY1 / Ubiquitin-like protein ATG12 / O94817* / autophagy related 12*  / complex / reaction
 ENSMUSG00000039201 A1A5B6 / Tbc1d25 / TBC1 domain family member 25 / Q3MII6*  / complex / reaction
 ENSMUSG00000038160 Atg5 / Q99J83 / Autophagy protein 5 / Q9H1Y0* / autophagy related 5*  / reaction / complex
 ENSMUSG00000025040 Fundc1 / Q9DB70 / FUN14 domain-containing protein 1 / Q8IVP5* / FUN14 domain containing 1*  / reaction / complex






 

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