ENSDARG00000023396


Danio rerio

Features
Gene ID: ENSDARG00000023396
  
Biological name :atg5
  
Synonyms : atg5 / ATG5 autophagy related 5 homolog (S. cerevisiae)
  
Possible biological names infered from orthology : Autophagy protein 5 / autophagy related 5 / Q99J83 / Q9H1Y0
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 7380463
Gene end: 7416532
  
Corresponding Affymetrix probe sets: Dr.12686.1.A1_at (Zebrafish Array)   Dr.12686.2.S1_at (Zebrafish Array)   NM_205618_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000030870
Ensembl peptide - ENSDARP00000124077
NCBI entrez gene - 494180     See in Manteia.
RefSeq - NM_001009914
RefSeq - NM_205618
RefSeq Peptide - NP_001009914
RefSeq Peptide - NP_991181
swissprot - F1RDC0
ZFIN ID - ZDB-GENE-040801-149
Ensembl - ENSDARG00000023396
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ATG5ENSGALG00000015387Gallus gallus
 ATG5ENSG00000057663Homo sapiens
 Atg5ENSMUSG00000038160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR007239  Autophagy-related protein 5


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000045 autophagosome assembly IMP
 biological_processGO:0000422 autophagy of mitochondrion IBA
 biological_processGO:0006501 C-terminal protein lipidation IBA
 biological_processGO:0006914 autophagy IMP
 biological_processGO:0006995 cellular response to nitrogen starvation IBA
 biological_processGO:0007399 nervous system development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0043416 regulation of skeletal muscle tissue regeneration IMP
 biological_processGO:0044804 autophagy of nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0034045 phagophore assembly site membrane IEA
 cellular_componentGO:0034274 Atg12-Atg5-Atg16 complex IBA
 molecular_functionGO:0019776 Atg8 ligase activity IBA


Pathways (from Reactome)
Pathway description
Macroautophagy
Pink/Parkin Mediated Mitophagy
Receptor Mediated Mitophagy


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood decreased volume , abnormal
Show

 ZFA:0000009 cardiac ventricle cardiac ventricle orientation atrium , abnormal
cardiac ventricle mislocalised , abnormal
cardiac ventricle increased distribution , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000084 yolk yolk vacuolated , abnormal
Show

 ZFA:0000101 diencephalon diencephalon dopaminergic neuron decreased amount , abnormal
diencephalon dopaminergic neuron decreased amount , exacerbated
Show

 ZFA:0000106 extension extension decreased length , abnormal
Show

 ZFA:0000107 eye eye edematous , abnormal
eye decreased size , abnormal
eye hypoplastic , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
heart structure , abnormal
heart autophagosome decreased amount , abnormal
heart increased amount , abnormal
heart mislocalised , abnormal
heart increased distribution , abnormal
heart physical object quality , abnormal
Show

 ZFA:0000155 somite somite structure , abnormal
Show

 ZFA:0000186 common cardinal vein common cardinal vein congested , abnormal
Show

 ZFA:0000360 heart tube heart tube linear , abnormal
Show

 ZFA:0000383 lateral rectus lateral rectus skeletal muscle tissue regeneration decreased process quality , abnormal
lateral rectus regenerating tissue decreased length , abnormal
lateral rectus regenerating tissue decreased amount , abnormal
Show

 ZFA:0000471 atrium atrium increased size , abnormal
atrium mislocalised , abnormal
atrium increased distribution , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
whole organism viability , abnormal
whole organism morphology , abnormal
whole organism bent , abnormal
whole organism decreased amount , abnormal
whole organism decreased life span , abnormal
whole organism increased amount , abnormal
Show

 ZFA:0001114 head head edematous , abnormal
head decreased size , abnormal
head hypoplastic , abnormal
Show

 ZFA:0001115 trunk trunk decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region cell death increased occurrence , abnormal
Show

 ZFA:0001315 atrioventricular canal atrioventricular canal mislocalised , abnormal
atrioventricular canal increased distribution , abnormal
Show

 ZFA:0001338 intestine intestine edematous , abnormal
intestine cell hypotrophic , abnormal
Show

 ZFA:0001617 otolith otolith decreased amount , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium cell detached from intestine , abnormal
Show

 ZFA:0009000 cell cell autophagosome assembly decreased process quality , abnormal
cell autophagosome decreased amount , abnormal
Show

 ZFA:0009301 dopaminergic neuron dopaminergic neuron decreased amount , abnormal
dopaminergic neuron decreased amount , exacerbated
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000037871 wipi2 / WD repeat domain, phosphoinositide interacting 2 / Q80W47* / Q9Y4P8*  / reaction / complex
 ENSDARG00000023396 atg5 / ATG5 autophagy related 5 homolog (S. cerevisiae) / Q99J83* / Q9H1Y0* / autophagy related 5* / Autophagy protein 5 *  / complex
 ENSDARG00000033609 map1lc3a / microtubule-associated protein 1 light chain 3 alpha / Q91VR7* / Q9H492* / Microtubule-associated proteins 1A/1B light chain 3A *  / complex / reaction
 ENSDARG00000040822 fundc1 / Q6DH87 / FUN14 domain containing 1 / Q9DB70* / Q8IVP5* / FUN14 domain-containing protein 1 *  / reaction / complex
 ENSDARG00000101127 map1lc3b / microtubule-associated protein 1 light chain 3 beta / Q9GZQ8* / Q9CQV6* / A6NCE7* / MAP1LC3B2* / Microtubule-associated proteins 1A/1B light chain 3B * / microtubule associated p...  / reaction / complex






 

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