ENSMUSG00000030967


Mus musculus

Features
Gene ID: ENSMUSG00000030967
  
Biological name :Zranb1
  
Synonyms : Q7M760 / zinc finger, RAN-binding domain containing 1 / Zranb1
  
Possible biological names infered from orthology : Q9UGI0 / zinc finger RANBP2-type containing 1
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: F3
Gene start: 132931142
Gene end: 132986391
  
Corresponding Affymetrix probe sets: 10558285 (MoGene1.0st)   10558295 (MoGene1.0st)   10338074 (MoGene1.0st)   10340168 (MoGene1.0st)   10340799 (MoGene1.0st)   10341269 (MoGene1.0st)   10341518 (MoGene1.0st)   10341580 (MoGene1.0st)   10343637 (MoGene1.0st)   10344074 (MoGene1.0st)   1415712_at (Mouse Genome 430 2.0 Array)   1427200_at (Mouse Genome 430 2.0 Array)   1436228_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000148867
Ensembl peptide - ENSMUSP00000033265
Ensembl peptide - ENSMUSP00000101763
Ensembl peptide - ENSMUSP00000147317
NCBI entrez gene - 360216     See in Manteia.
MGI - MGI:106441
RefSeq - XM_011241837
RefSeq - XM_006507967
RefSeq - XM_006507968
RefSeq - XM_006507969
RefSeq - XM_011241836
RefSeq - NM_207302
RefSeq - XM_006507966
RefSeq Peptide - NP_997185
swissprot - A0A1L1SQ24
swissprot - A0A1B0GQZ6
swissprot - Q7M760
Ensembl - ENSMUSG00000030967
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zranb1aENSDARG00000060257Danio rerio
 ZRANB1ENSGALG00000031474Gallus gallus
 Q9UGI0ENSG00000019995Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B2RUR8 / Otud7b / OTU domain-containing protein 7B / Q6GQQ9* / OTU deubiquitinase 7B*ENSMUSG0000003849517
Otud7a / Q8R554 / OTU domain-containing protein 7A / Q8TE49* / OTU deubiquitinase 7A*ENSMUSG0000003351017
Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*ENSMUSG0000001985015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001876  Zinc finger, RanBP2-type
 IPR003323  OTU domain
 IPR036443  Zinc finger, RanBP2-type superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007010 cytoskeleton organization ISO
 biological_processGO:0016055 Wnt signaling pathway IEA
 biological_processGO:0016477 cell migration IBA
 biological_processGO:0022604 regulation of cell morphogenesis ISO
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IBA
 biological_processGO:0035523 protein K29-linked deubiquitination IBA
 biological_processGO:0070536 protein K63-linked deubiquitination ISO
 biological_processGO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process ISO
 biological_processGO:1990168 protein K33-linked deubiquitination IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0043231 intracellular membrane-bounded organelle ISO
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IBA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000562 polydactyly "greater than 5 digits on one or more autopods" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Tmem79tm1.1(KOMP)Wtsi/Tmem79tm1.1(KOMP)Wtsi
Genetic Background: C57BL/6N-Tmem79tm1.1(KOMP)Wtsi/J

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/?,Tmem258tm1.1(KOMP)Vlcg/Tmem258+
Genetic Background: involves: C57BL/6NTac

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/?,Tmem258tm1.1(KOMP)Vlcg/Tmem258+
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Zranb1tm1d(EUCOMM)Hmgu/Zranb1tm1d(EUCOMM)Hmgu
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zranb1tm1d(EUCOMM)Hmgu/Zranb1tm1d(EUCOMM)Hmgu
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N

 MP:0008087 decreased T helper 1 cell number "reduced number of the subset of the type of T-helper cell whose cytokine production favors cellular immune responses and delayed type hypersensitivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/?,Tmem258tm1.1(KOMP)Vlcg/Tmem258+
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Zranb1tm1d(EUCOMM)Hmgu/Zranb1tm1d(EUCOMM)Hmgu
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N

 MP:0008578 decreased circulating interferon-gamma level "reduction in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Zranb1tm1d(EUCOMM)Hmgu/Zranb1tm1d(EUCOMM)Hmgu
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N

 MP:0008615 decreased circulating interleukin-17 level "reduction in the amount in the blood of a proinflammatory cytokine produced primarily by T-cells or their precursors" [MESH:D12.644.276.374.465.517]
Show

Allelic Composition: Zranb1tm1d(EUCOMM)Hmgu/Zranb1tm1d(EUCOMM)Hmgu
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N

 MP:0010220 decreased T-helper 17 cell number "reduced number of CD4-positive, alpha-beta T cells with the phenotype RORgamma-t-positive that produces IL-17" [CL:0000899]
Show

Allelic Composition: Gt(ROSA)26Sortm1(CAG-cas9*,-EGFP)Fezh/?,Tmem258tm1.1(KOMP)Vlcg/Tmem258+
Genetic Background: involves: C57BL/6NTac

Allelic Composition: Zranb1tm1d(EUCOMM)Hmgu/Zranb1tm1d(EUCOMM)Hmgu
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Zfp719tm1b(EUCOMM)Wtsi/Zfp719tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Zfp719tm1b(EUCOMM)Wtsi/Wtsi

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex






 

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