ENSMUSG00000033510


Mus musculus

Features
Gene ID: ENSMUSG00000033510
  
Biological name :Otud7a
  
Synonyms : Otud7a / OTU domain-containing protein 7A / Q8R554
  
Possible biological names infered from orthology : OTU deubiquitinase 7A / Q8TE49
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: C
Gene start: 63444751
Gene end: 63759028
  
Corresponding Affymetrix probe sets: 10553842 (MoGene1.0st)   1438286_at (Mouse Genome 430 2.0 Array)   1450250_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000057282
Ensembl peptide - ENSMUSP00000134821
Ensembl peptide - ENSMUSP00000135559
NCBI entrez gene - 170711     See in Manteia.
MGI - MGI:2158505
RefSeq - XM_017322005
RefSeq - NM_130880
RefSeq - XM_006540683
RefSeq - XM_011250811
RefSeq - XM_011250812
RefSeq Peptide - NP_570950
swissprot - H3BKW8
swissprot - H3BJ28
swissprot - Q8R554
Ensembl - ENSMUSG00000033510
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OTUD7AENSDARG00000045556Danio rerio
 OTUD7AENSGALG00000003802Gallus gallus
 OTUD7AENSG00000169918Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
B2RUR8 / Otud7b / OTU domain-containing protein 7B / Q6GQQ9* / OTU deubiquitinase 7B*ENSMUSG0000003849554
Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*ENSMUSG0000001985020
Q7M760 / Zranb1 / zinc finger, RAN-binding domain containing 1 / Q9UGI0* / zinc finger RANBP2-type containing 1*ENSMUSG0000003096713


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003323  OTU domain
 IPR033477  Cezanne-2 peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0035871 protein K11-linked deubiquitination IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0045088 regulation of innate immune response IBA
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0070536 protein K63-linked deubiquitination IBA
 biological_processGO:0071108 protein K48-linked deubiquitination IBA
 biological_processGO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0001405 impaired coordination "reduced ability to execute integrated movements of muscle" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0001489 decreased startle reflex "greater threshold or less severe reflex response to variable stimuli, often auditory; usually measured by amplitude of whole body flinch" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, What s Wrong With My Mouse?:ISBN 0-471-31639-3]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

Allelic Composition: Otud7aem1Cpsc/Otud7a+
Genetic Background: C57BL/6J-Otud7aem1Cpsc

 MP:0001529 abnormal vocalization "an inability, decreased ability or altered ability to produce sound from the vocal organs; or a general increase or decrease in the production of vocal sound" [cml:Cathleen M. Lutz , Mouse Genome Informatics Curator, J:85479]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

Allelic Composition: Otud7aem1Cpsc/Otud7a+
Genetic Background: C57BL/6J-Otud7aem1Cpsc

 MP:0003053 delayed tooth eruption "postponed onset of the growth of the teeth out of the gums" [pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0004753 abnormal miniature excitatory postsynaptic currents "defect in the size or duration of spontaneous currents detected in postsynaptic cells that occur in the absence of an excitatory impulse" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0008840 abnormal spike wave discharge "anomaly in the characteristic epileptiformic electroencephalographic (EEG) activity detected in generalized absence epilepsy" [PMID:16725200]
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Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0009142 decreased prepulse inhibition "decrease in the ability of a relatively mild stimulus to suppress the response to a strong, startle-eliciting stimulus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

 MP:0020508 decreased dendritic spine density "decrease in the number of dendritic spines in a given cross-sectional area of a dendrite" [MGI:smb]
Show

Allelic Composition: 1700007K13RikGt(OST3440)Lex/1700007K13RikGt(OST3440)Lex
Genetic Background: either: (involves: 129S5/SvEvBrd * C57BL/6J) or (involves: 129S5/SvEvBrd * C57BL/6J * FVB/N)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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