ENSG00000169918


Homo sapiens

Features
Gene ID: ENSG00000169918
  
Biological name :OTUD7A
  
Synonyms : OTUD7A / OTU deubiquitinase 7A / Q8TE49
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q13.3
Gene start: 31475398
Gene end: 31870789
  
Corresponding Affymetrix probe sets: 1553351_at (Human Genome U133 Plus 2.0 Array)   1560399_a_at (Human Genome U133 Plus 2.0 Array)   230783_at (Human Genome U133 Plus 2.0 Array)   232562_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453622
Ensembl peptide - ENSP00000453883
Ensembl peptide - ENSP00000305926
NCBI entrez gene - 161725     See in Manteia.
OMIM - 612024
RefSeq - NM_130901
RefSeq Peptide - NP_570971
swissprot - Q8TE49
swissprot - H0YMI7
swissprot - H0YN66
Ensembl - ENSG00000169918
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 OTUD7AENSDARG00000045556Danio rerio
 OTUD7AENSGALG00000003802Gallus gallus
 Otud7aENSMUSG00000033510Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OTUD7B / Q6GQQ9 / OTU deubiquitinase 7BENSG0000026452255
P21580 / TNFAIP3 / TNF alpha induced protein 3ENSG0000011850320
Q9UGI0 / ZRANB1 / zinc finger RANBP2-type containing 1ENSG0000001999513


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003323  OTU domain
 IPR009060  UBA-like superfamily
 IPR033477  Cezanne-2 peptidase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0035871 protein K11-linked deubiquitination IEA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IBA
 biological_processGO:0045088 regulation of innate immune response IBA
 biological_processGO:0050727 regulation of inflammatory response IBA
 biological_processGO:0070536 protein K63-linked deubiquitination IBA
 biological_processGO:0071108 protein K48-linked deubiquitination IBA
 biological_processGO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity TAS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IBA


Pathways (from Reactome)
Pathway description
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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