ENSG00000264522


Homo sapiens

Features
Gene ID: ENSG00000264522
  
Biological name :OTUD7B
  
Synonyms : OTUD7B / OTU deubiquitinase 7B / Q6GQQ9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: q21.2
Gene start: 149937812
Gene end: 150010676
  
Corresponding Affymetrix probe sets: 1555139_a_at (Human Genome U133 Plus 2.0 Array)   220031_at (Human Genome U133 Plus 2.0 Array)   227436_at (Human Genome U133 Plus 2.0 Array)   229488_at (Human Genome U133 Plus 2.0 Array)   238573_at (Human Genome U133 Plus 2.0 Array)   238994_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000408231
Ensembl peptide - ENSP00000462729
NCBI entrez gene - 56957     See in Manteia.
OMIM - 611748
RefSeq - XM_017001851
RefSeq - NM_020205
RefSeq - XM_011509787
RefSeq - XM_011509788
RefSeq - XM_017001850
RefSeq - XM_011509782
RefSeq - XM_011509783
RefSeq - XM_011509784
RefSeq - XM_011509785
RefSeq - XM_011509786
RefSeq Peptide - NP_064590
swissprot - Q5SZ59
swissprot - Q6GQQ9
Ensembl - ENSG00000264522
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otud7bENSDARG00000017220Danio rerio
 OTUD7BENSGALG00000013348Gallus gallus
 B2RUR8ENSMUSG00000038495Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
OTUD7A / Q8TE49 / OTU deubiquitinase 7AENSG0000016991860
P21580 / TNFAIP3 / TNF alpha induced protein 3ENSG0000011850322
Q9UGI0 / ZRANB1 / zinc finger RANBP2-type containing 1ENSG0000001999514


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003323  OTU domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002385 mucosal immune response IEA
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0016579 protein deubiquitination IEA
 biological_processGO:0032717 negative regulation of interleukin-8 production IDA
 biological_processGO:0035871 protein K11-linked deubiquitination IDA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0070536 protein K63-linked deubiquitination IDA
 biological_processGO:0071108 protein K48-linked deubiquitination IEA
 biological_processGO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
 biological_processGO:1900181 negative regulation of protein localization to nucleus IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity ISS
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity ISS
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity TAS


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000175104 TRAF6 / Q9Y4K3 / TNF receptor associated factor 6  / complex






 

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