ENSMUSG00000038495


Mus musculus

Features
Gene ID: ENSMUSG00000038495
  
Biological name :Otud7b
  
Synonyms : B2RUR8 / Otud7b / OTU domain-containing protein 7B
  
Possible biological names infered from orthology : OTU deubiquitinase 7B / Q6GQQ9
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 96104527
Gene end: 96161129
  
Corresponding Affymetrix probe sets: 10494335 (MoGene1.0st)   1428953_at (Mouse Genome 430 2.0 Array)   1429139_at (Mouse Genome 430 2.0 Array)   1435552_at (Mouse Genome 430 2.0 Array)   1457716_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000121847
Ensembl peptide - ENSMUSP00000088291
Ensembl peptide - ENSMUSP00000096449
Ensembl peptide - ENSMUSP00000115699
Ensembl peptide - ENSMUSP00000046413
NCBI entrez gene - 229603     See in Manteia.
MGI - MGI:2654703
RefSeq - XM_017319548
RefSeq - XM_006501385
RefSeq - XM_006501386
RefSeq - XM_006501389
RefSeq - XM_017319546
RefSeq - XM_017319547
RefSeq - NM_001025613
RefSeq - NM_001025614
RefSeq Peptide - NP_001020785
RefSeq Peptide - NP_001020784
swissprot - D3Z210
swissprot - D3YYZ8
swissprot - B2RUR8
Ensembl - ENSMUSG00000038495
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 otud7bENSDARG00000017220Danio rerio
 OTUD7BENSGALG00000013348Gallus gallus
 OTUD7BENSG00000264522Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Otud7a / Q8R554 / OTU domain-containing protein 7A / Q8TE49* / OTU deubiquitinase 7A*ENSMUSG0000003351059
Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*ENSMUSG0000001985021
Q7M760 / Zranb1 / zinc finger, RAN-binding domain containing 1 / Q9UGI0* / zinc finger RANBP2-type containing 1*ENSMUSG0000003096714


Protein motifs (from Interpro)
Interpro ID Name
 IPR002653  Zinc finger, A20-type
 IPR003323  OTU domain
 IPR009060  UBA-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IDA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0002385 mucosal immune response IMP
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0016579 protein deubiquitination IDA
 biological_processGO:0032717 negative regulation of interleukin-8 production ISO
 biological_processGO:0035871 protein K11-linked deubiquitination IBA
 biological_processGO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP
 biological_processGO:0070536 protein K63-linked deubiquitination ISO
 biological_processGO:0071108 protein K48-linked deubiquitination IMP
 biological_processGO:0071947 protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
 biological_processGO:1900181 negative regulation of protein localization to nucleus ISO
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0004843 thiol-dependent ubiquitin-specific protease activity ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IMP
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0036459 thiol-dependent ubiquitinyl hydrolase activity IMP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IDA
 molecular_functionGO:1990380 Lys48-specific deubiquitinase activity ISO


Pathways (from Reactome)
Pathway description
TNFR1-induced proapoptotic signaling
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000688 lymphoid hyperplasia "increased cell number in lymphatic tissues" [J:62478]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002462 abnormal granulocyte physiology "functional anomaly of neutrophils, eosinophils, or basophils " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Abcc8tm1.1Fmas/Abcc8tm1.1Fmas
Genetic Background: B6.129S2(Cg)-Abcc8tm1.1Fmas

 MP:0002495 increased IgA "greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004613 fusion of vertebral arches "improper union of the dorsal part of adjacent vertebra" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005154 increased B cell proliferation "greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Otud7btm1(NCOM)Cmhd/Otud7btm1(NCOM)Cmhd
Genetic Background: C57BL/6N-Otud7btm1(NCOM)Cmhd/Tcp

 MP:0009789 decreased susceptibility to bacterial infection induced morbidity/mortality "reduced likelihood that an organism will display the expected moribund state caused by a bacterial invasion or from components of or toxins produced by bacteria" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0010420 muscular ventricular septal defect "abnormal communications between the two lower chambers of the heart, involving the muscular septum and often occurring as multiple communications, and includes central muscular or midmuscular, apical, or marginal communications when the defect is along the RV-septal junction; any single defect observed from the LV aspect may have several openings on the RV aspect" [http://emedicine.medscape.com]
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Allelic Composition: Nphp1tm1.1(KOMP)Vlcg/Nphp1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Nphp1tm1.1(KOMP)Vlcg/Ucd

 MP:0010675 decreased activation-induced B cell apoptosis "decreased frequency of B cell apoptosis that occurs upon engagement of either the B cell receptor or CD40, but not both; the engagement leads to expression of fas or related receptors that make the B cell susceptible to fas-ligand mediated death" [PMID:11032170]
Show

Allelic Composition: Cdkn2atm2.1Brn/Cdkn2atm2.1Brn,Hdac2tm1.2Rdp/Hdac2tm1.2Rdp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027164 Traf6 / P70196 / TNF receptor-associated factor 6 / Q9Y4K3*  / complex






 

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