Manteia - Molecule gene

ENSMUSG00000020400

Mus musculus

Features

Gene ID:	ENSMUSG00000020400

Biological name :	Tnip1

Synonyms :	Q9WUU8 / TNFAIP3 interacting protein 1 / Tnip1

Possible biological names infered from orthology :	Q15025

Species:	Mus musculus

Chr. number:	11
Strand:	-1
Band:	B1.3
Gene start:	54910785
Gene end:	54962917

Corresponding Affymetrix probe sets:	10385941 (MoGene1.0st) 1427689_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000104514 Ensembl peptide - ENSMUSP00000104513 Ensembl peptide - ENSMUSP00000104517 Ensembl peptide - ENSMUSP00000122836 Ensembl peptide - ENSMUSP00000116721 Ensembl peptide - ENSMUSP00000018482 Ensembl peptide - ENSMUSP00000099791 Ensembl peptide - ENSMUSP00000099792 NCBI entrez gene - 57783 See in Manteia. MGI - MGI:1926194 RefSeq - XM_011249164 RefSeq - NM_001199275 RefSeq - NM_001199276 RefSeq - NM_001271455 RefSeq - NM_001271456 RefSeq - NM_021327 RefSeq - XM_006533846 RefSeq - XM_006533847 RefSeq - XM_006533848 RefSeq - XM_011249162 RefSeq - XM_011249163 RefSeq Peptide - NP_001186205 RefSeq Peptide - NP_001258384 RefSeq Peptide - NP_001258385 RefSeq Peptide - NP_067302 RefSeq Peptide - NP_001186204 swissprot - E9QM75 swissprot - D3Z410 swissprot - D3Z3B6 swissprot - Q9WUU8 swissprot - D3Z2W0 Ensembl - ENSMUSG00000020400

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Ortholog name	ID	Species
tnip1	ENSDARG00000015653	Danio rerio
TNIP1	ENSGALG00000004496	Gallus gallus
TNIP1	ENSG00000145901	Homo sapiens

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Tnip3 / TNFAIP3 interacting protein 3 / Q96KP6*	ENSMUSG00000044162	10

Protein motifs (from Interpro)

Interpro ID	Name
IPR033372	TNFAIP3-interacting protein 1

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0002755	MyD88-dependent toll-like receptor signaling pathway	IEA
biological_process	GO:0006954	inflammatory response	IEA
biological_process	GO:0007159	leukocyte cell-cell adhesion	ISS
biological_process	GO:0009101	glycoprotein biosynthetic process	ISO
biological_process	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling	IEA
biological_process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP
biological_process	GO:0050727	regulation of inflammatory response	IEA
biological_process	GO:0050729	positive regulation of inflammatory response	IMP
biological_process	GO:0070373	negative regulation of ERK1 and ERK2 cascade	IEA
biological_process	GO:0071222	cellular response to lipopolysaccharide	IBA
biological_process	GO:0085032	modulation by symbiont of host I-kappaB kinase/NF-kappaB cascade	ISO
biological_process	GO:1903003	positive regulation of protein deubiquitination	ISO
cellular_component	GO:0005634	nucleus	IEA
cellular_component	GO:0005654	nucleoplasm	ISO
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005829	cytosol	ISO
molecular_function	GO:0005515	protein binding	IPI
molecular_function	GO:0019901	protein kinase binding	IBA
molecular_function	GO:0031593	polyubiquitin modification-dependent protein binding	IDA
molecular_function	GO:0042802	identical protein binding	ISO
molecular_function	GO:0051019	mitogen-activated protein kinase binding	ISO

Pathways (from Reactome)

Pathway description

Ovarian tumor domain proteases

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0000208	decreased hematocrit	"less than the average percentage of a volume of a blood sample occupied by red blood cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa
MP:0000219	increased neutrophil count	"greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0000220	increased monocyte count	"greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0000322	increased granulocyte number	"greater than expected number of leukocytes that have abundant granules in the cytoplasm: basophils, neutrophils, or eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0000477	abnormal intestine morphology	"malformation of the digestive tube passing from the stomach to the anus" [J:48968]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Ripk2^tm1Flv/Ripk2^tm1Flv,Tnip1^tm1.1Pcoh/Tnip1^tm1.1Pcoh Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
MP:0000600	liver hypoplasia	"reduced size of liver due to decreased cell number " [J:57631]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa
MP:0000685	abnormal immune system morphology	"morphological anomalies in the organs or cells associated with the development and formation of lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^tm1.2Pcoh/Tnip1^tm1.2Pcoh Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0000691	enlarged spleen	"increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Ripk2^tm1Flv/Ripk2^tm1Flv,Tnip1^tm1.1Pcoh/Tnip1^tm1.1Pcoh Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0000693	spleen hyperplasia	"increased cell number in the spleen" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33401]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0000696	abnormal Peyer s patches morphology	"anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0000702	enlarged lymph nodes	"lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Ripk2^tm1Flv/Ripk2^tm1Flv,Tnip1^tm1.1Pcoh/Tnip1^tm1.1Pcoh Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0001262	decreased body weight	"lower than normal average weight " [J:61295]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0001265	reduced body size	"smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]	Show Allelic Composition: Trp73^tm1Mak/Trp73^tm1Mak Genetic Background: involves: 129P2/OlaHsd
MP:0001577	anemia	"less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0001614	abnormal vasculature	"anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0001864	vasculitis	"inflammation of a blood or lymph vessel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0002083	premature death	"death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^tm1.2Pcoh/Tnip1^tm1.2Pcoh Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0002359	abnormal spleen germinal center morphology	"anomalous structure or formation of the area of the spleen in which activated follicles are located" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology:ISBN 0-397-51047-0]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0002435	abnormal effector T cell morphology/development	"anomalous structure, formation, or numbers of the set of T lymphocytes that are able to respond immediately upon contact with cells bearing the appropriate peptide:MHC complex for the cell" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0002439	abnormal plasma cell morphology/development	"anomalous structure, differentiation, or number of the specialized forms of B-lympocytes which produce and secrete immunoglobulin" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0002461	increased circulating immunoglobulin concentration	"greater than normal immunoglobulin level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0002471	abnormal complement cascade	"impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0002493	increased IgG	"greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0002494	increased IgM	"greater than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002495	increased IgA	"greater than normal immunoglobulin class A level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0002497	increased IgE	"greater than normal immunoglobulin class E level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0002743	glomerulonephritis	"glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0002874	decreased hemoglobin content	"decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0002962	increased protein excretion	"greater than the normal amount of serum proteins voided by the kidneys" [RGD:Rat Genome Database submission]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0003333	liver fibrosis	"invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0003717	pallor	"an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa
MP:0003887	increased hepatocyte apoptosis	"increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa
MP:0004200	reduced fetal size	"smaller proportions of a fetus compared to littermates (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa
MP:0004762	increased anti-double stranded DNA antibody level	"increase in the level of antibodies that recognize double stranded DNA" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^tm1.1Pcoh/Tnip1⁺ Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004794	increased anti-nuclear antigen antibody level	"elevated level of antibodies to nuclear antigens present in the sera" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0004801	increased susceptibility to systemic lupus erythematosus	"greater likelihood that an organism will develop inflammatory connective tissue symptoms characteristic of lupus including skin rash, arthritis and inflammation of different organs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0004839	bile duct hyperplasia	"overdevelopment or increased size of the bile ducts, usually due to an increase in the number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0004952	increased spleen weight	"greater than average weight of the organ that functions to filter blood and to store red corpuscles and platelets" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0005014	increased B cell number	"greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0005150	cachexia	"general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0005154	increased B cell proliferation	"greater than the normal response by B cells to grow and divide in response to stimuli " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0008049	increased memory T cell number	"greater number of the set of long-lived T cells differentiated from T cells activated by a specific antigen encountered during a past immune response" [adiehl:Alex Diehl_MGI GO curator, Biology-Online.org:http://www.biology-online.org/, MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0008097	increased plasma cell number	"greater number of terminally differentiated, post-mitotic, short-lived cells of the B cell lineage devoted to producing large amounts of immunoglobulin" [CL:0000786, ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0008102	lymph node hyperplasia	"overdevelopment or increased size, usually due to increased cell number, in the lymph nodes" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008177	increased germinal center B cell number	"greater number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0008246	abnormal leukocyte morphology	"any structural anomaly of nucleated cells of the myeloid or lymphoid lineages, found in blood or other tissue" [CL:0000738, MESH:A11.118.637]	Show Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0008476	increased spleen red pulp amount	"increase in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0008478	increased spleen white pulp amount	"increase in the quantity of the parenchymatous tissue of the spleen that surrounds splenic blood vessels, consists of compact masses of lymphatic cells and is where foreign material removed from the blood is used to initiate an immune reaction that results in the production of antibodies" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0008499	increased IgG1 level	"greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008500	increased IgG2a level	"greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0008501	increased IgG2b level	"greater than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008502	increased IgG3 level	"greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0008524	increased plasmacytoid dendritic cell number	"greater number of phagocytic dendritic cells that are morphologically similar to plasma cells, but do not express B lineage markers, and produce large amounts of alpha/beta interferons (IFN-/) in response to viral and bacterial stimuli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:15596797]	Show Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0008560	increased tumor necrosis factor secretion	"increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0008663	increased interleukin-12 secretion	"increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]	Show Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0008664	decreased interleukin-12 secretion	"reduction in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells and plays a role in the stimulation of interferon-gamma production by T-cells and natural killer cells" [MESH:D12.644.276.374.465.512]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008669	increased interleukin-12b secretion	"increase in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0008670	decreased interleukin-12b secretion	"reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]	Show Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6
MP:0008690	increased interleukin-23 secretion	"increase in the production or release of a heterodimeric cytokine that plays a role in innate and adaptive immune responses; it is produced by dendritic cells, macrophages and a variety of other immune cells" [MESH:D12.644.276.374.465.759]	Show Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0008705	increased interleukin-6 secretion	"increase in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0009431	decreased fetal weight	"reduced weight of a fetus compared to controls (sensu Mus: from E14 through birth)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa
MP:0010186	increased T follicular helper cell number	"greater number of the CD4-positive, CXCR5-positive, CCR7-negative alpha-beta T cells located in follicles of secondary lymph nodes that expresses high levels of BCL-6, ICOS and PD1 and stimulate follicular B cells to undergo class-switching and antibody production" [CL:0002038, PMID:19855402]	Show Allelic Composition: Map3k10^tm1Dsd/Map3k10^tm1Dsd,Map3k11^tm1Rjd/Map3k11^tm1Rjd Genetic Background: involves: 129 * 129S6/SvEvTac * C57BL/6J
MP:0010763	abnormal hematopoietic stem cell physiology	"any functional anomaly or number of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; HSCs give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]	Show Allelic Composition: Tnip1^tm1.2Ama/Tnip1^tm1.2Ama,Tg(Itgax-cre)1-1Reiz/0 Genetic Background: involves: C57BL/6 * C57BL/6J * CBA
MP:0011090	partial perinatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa Allelic Composition: Tnf^tm1Ljo/Tnf⁺,Tnip1^tm1.1Ama/Tnip1^tm1.1Ama Genetic Background: involves: 129S1/Sv * C57BL/6J
MP:0011101	partial prenatal lethality	"the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]	Show Allelic Composition: Trp73^tm1Mak/Trp73^tm1Mak Genetic Background: involves: 129P2/OlaHsd Allelic Composition: Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * C57BL/6 Allelic Composition: Tnfrsf1a^tm1Mak/Tnfrsf1a^tm1Mak,Tnip1^{Gt(E059E05)Wrst}/Tnip1^{Gt(E059E05)Wrst} Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
MP:0013501	increased fibroblast apoptosis	"increase in the timing or the number of fibroblast cells undergoing programmed cell death" [MGI:csmith]	Show Allelic Composition: Kmt2e^tm1Apa/Kmt2e^tm1Apa Genetic Background: 129S6/SvEvTac-Kmt2e^tm1Apa Allelic Composition: Tnip1^tm1.1Pcoh/Tnip1^tm1.1Pcoh Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Interacting proteins (from Reactome)

Interactor ID	Name	Interaction type
ENSMUSG00000019850	Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*	/ complex / reaction

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr