ENSMUSG00000004535


Mus musculus

Features
Gene ID: ENSMUSG00000004535
  
Biological name :Tax1bp1
  
Synonyms : Q3UKC1 / Tax1-binding / Tax1bp1
  
Possible biological names infered from orthology : Q86VP1 / Tax1 binding protein 1
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: B3
Gene start: 52713729
Gene end: 52766780
  
Corresponding Affymetrix probe sets: 10538318 (MoGene1.0st)   1420174_s_at (Mouse Genome 430 2.0 Array)   1420175_at (Mouse Genome 430 2.0 Array)   1442901_at (Mouse Genome 430 2.0 Array)   1448399_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000116059
Ensembl peptide - ENSMUSP00000122922
Ensembl peptide - ENSMUSP00000119522
Ensembl peptide - ENSMUSP00000079548
NCBI entrez gene - 52440     See in Manteia.
MGI - MGI:1289308
RefSeq - XM_006506371
RefSeq - XM_006506369
RefSeq - XM_006506370
RefSeq - NM_025816
RefSeq Peptide - NP_080092
RefSeq Peptide - NP_001342525
swissprot - Q3UKC1
swissprot - D3Z715
swissprot - D3Z152
swissprot - D3Z213
Ensembl - ENSMUSG00000004535
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tax1bp1aENSDARG00000098288Danio rerio
 tax1bp1bENSDARG00000056856Danio rerio
 TAX1BP1ENSGALG00000042822Gallus gallus
 Q86VP1ENSG00000106052Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q8CGU1 / Calcoco1 / Calcium-binding and coiled-coil domain-containing protein 1 / Q9P1Z2* / calcium binding and coiled-coil domain 1*ENSMUSG0000002305520
A2A6M5 / Calcoco2 / Calcium-binding and coiled-coil domain-containing protein 2 / Q13137* / calcium binding and coiled-coil domain 2*ENSMUSG0000000605612


Protein motifs (from Interpro)
Interpro ID Name
 IPR012852  Calcium binding and coiled-coil domain-like
 IPR013083  Zinc finger, RING/FYVE/PHD-type


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0032088 negative regulation of NF-kappaB transcription factor activity IMP
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019900 kinase binding IPI
 molecular_functionGO:0043130 ubiquitin binding NAS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Regulation of TNFR1 signaling
Negative regulators of DDX58/IFIH1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0000285 abnormal cardiac valve morphology "malformation of the membranous folds of the heart that prevent reflux of fluid" [J:18048]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0001853 heart inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the heart" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0002148 immune system: hypersensitivity "immune response that results in tissue injury" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0004947 skin inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the skin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0008489 postnatal slow weight gain "the weight gain over a span of postnatal developmental time is slower than controls, with or without ever attaining a similar weight to controls as adults" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0008657 increased interleukin-1 beta secretion "increase in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0008687 increased interleukin-2 secretion "increase in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Hprtb-m2/Y
Genetic Background: involves: 129 * 129S/SvEv

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000019850 Q60769 / Tnfaip3 / tumor necrosis factor, alpha-induced protein 3 / P21580* / TNF alpha induced protein 3*  / complex
 ENSMUSG00000042349 Ikbke / Q9R0T8 / Inhibitor of nuclear factor kappa-B kinase subunit epsilon / Q14164*  / complex / reaction
 ENSMUSG00000020115 Tbk1 / Q9WUN2 / TANK-binding kinase 1 / Q9UHD2*  / reaction / complex






 

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