ENSG00000168884


Homo sapiens

Features
Gene ID: ENSG00000168884
  
Biological name :TNIP2
  
Synonyms : Q8NFZ5 / TNFAIP3 interacting protein 2 / TNIP2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 4
Strand: -1
Band: p16.3
Gene start: 2741648
Gene end: 2756376
  
Corresponding Affymetrix probe sets: 218335_x_at (Human Genome U133 Plus 2.0 Array)   232160_s_at (Human Genome U133 Plus 2.0 Array)   48531_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000427613
Ensembl peptide - ENSP00000321203
Ensembl peptide - ENSP00000426314
NCBI entrez gene - 79155     See in Manteia.
OMIM - 610669
RefSeq - NM_001161527
RefSeq - NM_001292016
RefSeq - NM_024309
RefSeq Peptide - NP_001154999
RefSeq Peptide - NP_001278945
RefSeq Peptide - NP_077285
swissprot - Q8NFZ5
swissprot - D6RGJ2
Ensembl - ENSG00000168884
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tnip2ENSDARG00000074501Danio rerio
 TNIP2ENSGALG00000015666Gallus gallus
 Tnip2ENSMUSG00000059866Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR022008  TSG101 and ALIX binding domain of CEP55
 IPR032419  NF-kappa-B essential modulator NEMO, CC2-LZ domain
 IPR034735  NEMO, Zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006915 apoptotic process IEA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007249 I-kappaB kinase/NF-kappaB signaling IEA
 biological_processGO:0016579 protein deubiquitination TAS
 biological_processGO:0023035 CD40 signaling pathway IEA
 biological_processGO:0034134 toll-like receptor 2 signaling pathway IEA
 biological_processGO:0034138 toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034162 toll-like receptor 9 signaling pathway IEA
 biological_processGO:0043032 positive regulation of macrophage activation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0050871 positive regulation of B cell activation IEA
 biological_processGO:0051403 stress-activated MAPK cascade TAS
 biological_processGO:0070498 interleukin-1-mediated signaling pathway IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:2000352 negative regulation of endothelial cell apoptotic process IDA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0031593 polyubiquitin modification-dependent protein binding IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070530 K63-linked polyubiquitin modification-dependent protein binding IEA


Pathways (from Reactome)
Pathway description
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Ovarian tumor domain proteases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000109320 NFKB1 / P19838 / nuclear factor kappa B subunit 1  / complex / reaction
 ENSG00000107968 MAP3K8 / P41279 / mitogen-activated protein kinase kinase kinase 8  / complex / reaction
 ENSG00000104365 IKBKB / O14920 / inhibitor of nuclear factor kappa B kinase subunit beta  / reaction
 ENSG00000072803 FBXW11 / Q9UKB1 / F-box and WD repeat domain containing 11  / reaction / complex
 ENSG00000118503 P21580 / TNFAIP3 / TNF alpha induced protein 3  / reaction / complex
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / complex / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / complex / reaction
 ENSG00000055130 CUL1 / Q13616 / cullin 1  / reaction / complex






 

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