ENSMUSG00000021795


Mus musculus

Features
Gene ID: ENSMUSG00000021795
  
Biological name :Sftpd
  
Synonyms : P50404 / Pulmonary surfactant-associated protein D / Sftpd
  
Possible biological names infered from orthology : P35247 / surfactant protein D
  
Species: Mus musculus
  
Chr. number: 14
Strand: -1
Band: B
Gene start: 41172214
Gene end: 41185149
  
Corresponding Affymetrix probe sets: 10419096 (MoGene1.0st)   1420378_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076383
NCBI entrez gene - 20390     See in Manteia.
MGI - MGI:109515
RefSeq - NM_009160
RefSeq Peptide - NP_033186
swissprot - P50404
Ensembl - ENSMUSG00000021795
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbl1ENSDARG00000068221Danio rerio
 hbl2ENSDARG00000094681Danio rerio
 hbl4ENSDARG00000054202Danio rerio
 mbl2ENSDARG00000068220Danio rerio
 SFTPDENSG00000133661Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mbl1 / P39039 / Mannose-binding protein A ENSMUSG0000003778028
Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*ENSMUSG0000002178928
Mbl2 / P41317 / mannose-binding lectin (protein C) 2 / P11226* / mannose binding lectin 2*ENSMUSG0000002486327
Colec11 / collectin subfamily member 11 / Q9BWP8*ENSMUSG0000003665522
Q8CF98 / Colec10 / Collectin-10 / Q9Y6Z7* / collectin subfamily member 10*ENSMUSG0000003859121


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR008160  Collagen triple helix repeat
 IPR015097  Lung surfactant protein D coiled-coil trimerisation
 IPR016133  Insect cysteine-rich antifreeze protein
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033990  Collectin, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0007585 respiratory gaseous exchange IEA
 biological_processGO:0043129 surfactant homeostasis IEA
 biological_processGO:0043152 induction of bacterial agglutination IEA
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0052405 negative regulation by host of symbiont molecular function IEA
 biological_processGO:1905226 regulation of adhesion of symbiont to host epithelial cell IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Signal regulatory protein family interactions
Surfactant metabolism
Regulation of TLR by endogenous ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
Show

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001179 thicker alveolar septa 
Show

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001183 overexpanded alveoli "expanded volume of the saclike terminal dilation of the respiratory bronchioles" [J:66345]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

Allelic Composition: Mmp9tm1Tvu/Mmp9tm1Tvu,Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * FVB/N

Allelic Composition: Mmp12tm1Sds/Mmp12tm1Sds,Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * Black Swiss * FVB/N

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001942 abnormal lung volume "anomaly in the amount of air that the lungs contain at various points of the respiratory cycle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0001958 emphysema "lung disease characterized by increased size of terminal bronchioles with destructive changes in their walls and reduction in number" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33629]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0003209 abnormal pulmonary elastic fiber morphology "malformation of a slender connective tissue fiber in pulmonary tissue characterized by great elasticity" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0004780 abnormal surfactant secretion "anomaly in the production or release from pneumocytes of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0004781 abnormal surfactant composition "anomaly in the chemical consituents of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0006050 pulmonary fibrosis "formation of fibrous tissue within the lung often resulting from inflammation or injury " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
Show

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Sftpdtm1Jhf/Sftpdtm1Jhf
Genetic Background: involves: 129P2/OlaHsd * Black Swiss

 MP:0010810 increased type II pneumocyte number "greater number of the granular and roughly cuboidal cells typically found at the alveolar-septal junction that modulate the fluid surrounding the alveolar epithelium by secreting and recycling surfactants, and also contribute to tissue repair and can differentiate after injury into a type I pneumocyte; type II cells cover a much smaller surface area than type I cells (less than 5 percent), but are much more numerous and contain lamellar bodies on the apical surface where surfactant is stored" [ISBN:0412046911, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", PMID:8540632]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010815 enlarged alveolar lamellar bodies "increased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

 MP:0010898 abnormal pulmonary alveolus epithelium morphology "any structural anomaly of the epithelial layer of the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

Allelic Composition: Sftpdtm1Haw/Sftpdtm1Haw
Genetic Background: involves: C57BL/6J * CD-1

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / reaction / complex
 ENSMUSG00000027995 Tlr2 / toll-like receptor 2 / O60603*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000044827 Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*  / complex / reaction
 ENSMUSG00000021795 Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*  / reaction / complex / -
 ENSMUSG00000054594 Oscar / Q8VBT3 / Osteoclast-associated immunoglobulin-like receptor / Q8IYS5*  / reaction / complex






 

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