ENSMUSG00000037780


Mus musculus

Features
Gene ID: ENSMUSG00000037780
  
Biological name :Mbl1
  
Synonyms : Mannose-binding protein A / Mbl1 / P39039
  
Possible biological names infered from orthology :
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 41151458
Gene end: 41159601
  
Corresponding Affymetrix probe sets: 10414211 (MoGene1.0st)   1419578_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048765
Ensembl peptide - ENSMUSP00000153147
NCBI entrez gene - 17194     See in Manteia.
MGI - MGI:96923
RefSeq - XM_017315906
RefSeq - NM_010775
RefSeq - XM_006518669
RefSeq Peptide - NP_034905
swissprot - P39039
swissprot - A0A2C9F2B6
Ensembl - ENSMUSG00000037780
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbl1ENSDARG00000068221Danio rerio
 hbl2ENSDARG00000094681Danio rerio
 hbl4ENSDARG00000054202Danio rerio
 mbl2ENSDARG00000068220Danio rerio
 MBL2ENSGALG00000002507Gallus gallus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mbl2 / P41317 / mannose-binding lectin (protein C) 2 / P11226* / mannose binding lectin 2*ENSMUSG0000002486353
Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*ENSMUSG0000002179544
Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*ENSMUSG0000002178933
Q8CF98 / Colec10 / Collectin-10 / Q9Y6Z7* / collectin subfamily member 10*ENSMUSG0000003859130
Colec11 / collectin subfamily member 11 / Q9BWP8*ENSMUSG0000003665528


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR008160  Collagen triple helix repeat
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033990  Collectin, C-type lectin-like domain
 IPR037570  Mannose-binding protein


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001867 complement activation, lectin pathway IGI
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006958 complement activation, classical pathway IEA
 biological_processGO:0044130 negative regulation of growth of symbiont in host IGI
 biological_processGO:0045087 innate immune response IEA
 biological_processGO:0050766 positive regulation of phagocytosis IGI
 biological_processGO:0050830 defense response to Gram-positive bacterium IGI
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0051873 killing by host of symbiont cells IGI
 biological_processGO:0070207 protein homotrimerization IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005581 collagen trimer IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0005537 mannose binding IBA
 molecular_functionGO:0030246 carbohydrate binding IEA
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0048306 calcium-dependent protein binding IEA
 molecular_functionGO:0070273 phosphatidylinositol-4-phosphate binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0001798 impaired macrophage phagocytosis "reduced ability of these phagocytic cells to internalize particulate matter" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0001806 decreased IgM "less than normal immunoglobulin class M level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

Allelic Composition: Mbl1tm1Kata/Mbl1tm1Kata,Mbl2tm1Kata/Mbl2tm1Kata
Genetic Background: involves: 129 * C57BL/6J

 MP:0002458 abnormal B cell number "deviation from the normal number of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0002471 abnormal complement cascade "impaired ability of the complement proteins to act in concert and attack extracellular pathogens" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Selltm1Tft/Selltm1Tft
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002490 abnormal circulating immunoglobulin concentration "deviation from the normal levels of glycoproteins present in the blood and other tissue, often functioning as antibodies" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbl1tm1Kata/Mbl1tm1Kata,Mbl2tm1Kata/Mbl2tm1Kata
Genetic Background: involves: 129 * C57BL/6J

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0005025 response to infection "the body s reaction to invasion and multiplication of microorganisms in its tissues, or the body s reaction to components of or toxins produced by pathogenic mircroorganisms " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mbl1tm1Kata/Mbl1tm1Kata,Mbl2tm1Kata/Mbl2tm1Kata
Genetic Background: involves: 129 * C57BL/6J

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008178 decreased germinal center B cell number "reduced number of rapidly cycling mature B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA), and are involved in T-dependent immune responses; germinal center B cells are found typically in the germinal centers of lymph nodes and spleen" [CL:0000844, GO:0002314, ISBN:0781735149]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0008497 decreased IgG2b level "less than normal immunoglobulin class G2b level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008500 increased IgG2a level "greater than normal immunoglobulin class G2a level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008502 increased IgG3 level "greater than normal immunoglobulin class G3 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Eaf2tm1Zhow/Eaf2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008552 abnormal circulating tumor necrosis factor level "anomaly in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0008554 decreased circulating tumor necrosis factor level "reduction in the amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0008595 abnormal circulating interleukin-6 level "anomaly in the amount in the blood of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
Show

Allelic Composition: Lhfpl5hscy/Lhfpl5hscy
Genetic Background: involves: B6(MOR)-Tmhshscy/J * CAST/Ei

 MP:0009764 decreased sensitivity to induced morbidity/mortality "increase in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tmod1tm1Sung/Tmod1tm1Sung
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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