ENSMUSG00000021789


Mus musculus

Features
Gene ID: ENSMUSG00000021789
  
Biological name :Sftpa1
  
Synonyms : Sftpa1 / surfactant associated protein A1
  
Possible biological names infered from orthology : Q8IWL1 / Q8IWL2 / SFTPA2 / surfactant protein A1 / surfactant protein A2
  
Species: Mus musculus
  
Chr. number: 14
Strand: 1
Band: B
Gene start: 41131782
Gene end: 41136452
  
Corresponding Affymetrix probe sets: 10414202 (MoGene1.0st)   1422334_a_at (Mouse Genome 430 2.0 Array)   1429626_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000022314
Ensembl peptide - ENSMUSP00000129696
NCBI entrez gene - 20387     See in Manteia.
MGI - MGI:109518
RefSeq - NM_023134
RefSeq Peptide - NP_075623
swissprot - Q9CQI1
Ensembl - ENSMUSG00000021789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hbl1ENSDARG00000068221Danio rerio
 hbl2ENSDARG00000094681Danio rerio
 hbl4ENSDARG00000054202Danio rerio
 mbl2ENSDARG00000068220Danio rerio
 SFTPA1ENSGALG00000002496Gallus gallus
 SFTPA2ENSGALG00000002503Gallus gallus
 Q8IWL1ENSG00000185303Homo sapiens
 Q8IWL2ENSG00000122852Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Sftpd / P50404 / Pulmonary surfactant-associated protein D / P35247* / surfactant protein D*ENSMUSG0000002179542
Mbl2 / P41317 / mannose-binding lectin (protein C) 2 / P11226* / mannose binding lectin 2*ENSMUSG0000002486335
Mbl1 / P39039 / Mannose-binding protein A ENSMUSG0000003778032
Q8CF98 / Colec10 / Collectin-10 / Q9Y6Z7* / collectin subfamily member 10*ENSMUSG0000003859129
Colec11 / collectin subfamily member 11 / Q9BWP8*ENSMUSG0000003665528


Protein motifs (from Interpro)
Interpro ID Name
 IPR001304  C-type lectin-like
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR018378  C-type lectin, conserved site
 IPR033990  Collectin, C-type lectin-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0007623 circadian rhythm IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032526 response to retinoic acid IEA
 biological_processGO:0033189 response to vitamin A IEA
 biological_processGO:0050766 positive regulation of phagocytosis IEA
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0055093 response to hyperoxia IEA
 biological_processGO:0070741 response to interleukin-6 IEA
 biological_processGO:0070849 response to epidermal growth factor IEA
 biological_processGO:0071260 cellular response to mechanical stimulus IEA
 biological_processGO:0071732 cellular response to nitric oxide IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005771 multivesicular body IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA


Pathways (from Reactome)
Pathway description
Toll Like Receptor 4 (TLR4) Cascade
Signal regulatory protein family interactions
Surfactant metabolism
Regulation of TLR by endogenous ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000220 increased monocyte count "greater than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0001175 abnormal lung morphology "malformed organ of respiration" [J:35802]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0001179 thicker alveolar septa 
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0001861 lung inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the lung" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Tyrc-112K/Tyrc-ch
Genetic Background: involves: 101/R1 * C3Hf/R1 * St.2A

Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrc-112K/Tyrc-ch
Genetic Background: involves: 101/R1 * C3Hf/R1 * St.2A

Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C3H/HeN

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0004777 abnormal phospholipid level "anomalous concentration of the fat derivatives in which one fatty acid has been replaced by a phosphate group" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: B6.129P2-Sftpa1tm1Kor

 MP:0004782 abnormal surfactant physiology "anomaly in the production, composition or function of surfactant, a phospholipid present in the lungs that controls surface tension in the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd * NIH Black Swiss

Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: B6.129P2-Sftpa1tm1Kor

 MP:0008245 abnormal alveolar macrophage morphology "any structural anomaly of the round, granular, mononuclear phagocytes found in the alveoli of the lungs which ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells" [CL:0000583, MESH:A.11.329.372.600]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0008751 abnormal interleukin level "deviation from the normal levels of soluble factors which stimulate growth-related activities of leukocytes as well as other cell types; they enhance cell proliferation and differentiation, DNA synthesis, secretion of other biologically active molecules and responses to immune and inflammatory stimuli" [MESH:D12.644.276.374.465]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0010895 increased lung compliance "increased ability of the lung to distend in response to pressure without disruption, usually expressed as the unit volume of change in the lung per unit of pressure" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition"]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0010898 abnormal pulmonary alveolus epithelium morphology "any structural anomaly of the epithelial layer of the alveoli" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc3a1pbl/Slc3a1pbl
Genetic Background: involves: C3HeB/FeJ * MRL/MpJ

 MP:0010901 abnormal pulmonary alveolar parenchyma morphology "any structural anomaly of the distinguishing cell types of the lung alveolar tissue, including pulmonary epithelial cells (pneumocytes), alveolar capillary endothelial cells, interstitial cells (fibroblasts) and alveolar macrophages" [ISBN:070202788 "Saunders Comprehensive Veterinary Dictionary, 3rd edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: CoblC101/CoblC101,Vangl2Lp/Vangl2+
Genetic Background: involves: 129S2/SvPas * LPT/LeJ

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Sftpa1tm1Kor/Sftpa1tm1Kor
Genetic Background: involves: 129P2/OlaHsd * Black Swiss * C3H/HeN

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021789 Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*  / - / complex
 ENSMUSG00000046841 Ckap4 / Q8BMK4 / Cytoskeleton-associated protein 4 / Q07065*  / complex / reaction
 ENSMUSG00000025779 Ly96 / Q9JHF9 / lymphocyte antigen 96 / Q9Y6Y9*  / complex / reaction
 ENSMUSG00000027995 Tlr2 / toll-like receptor 2 / O60603*  / reaction / complex
 ENSMUSG00000039005 Tlr4 / Q9QUK6 / toll-like receptor 4 / O00206*  / reaction / complex
 ENSMUSG00000044827 Tlr1 / Q9EPQ1 / toll-like receptor 1 / Q15399*  / complex / reaction






 

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