ENSMUSG00000046841


Mus musculus

Features
Gene ID: ENSMUSG00000046841
  
Biological name :Ckap4
  
Synonyms : Ckap4 / Cytoskeleton-associated protein 4 / Q8BMK4
  
Possible biological names infered from orthology : Q07065
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: C1
Gene start: 84526305
Gene end: 84534062
  
Corresponding Affymetrix probe sets: 10371387 (MoGene1.0st)   1426754_x_at (Mouse Genome 430 2.0 Array)   1426755_at (Mouse Genome 430 2.0 Array)   1452181_at (Mouse Genome 430 2.0 Array)   1455019_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000050336
Ensembl peptide - ENSMUSP00000130304
NCBI entrez gene - 216197     See in Manteia.
MGI - MGI:2444926
RefSeq - NM_175451
RefSeq Peptide - NP_780660
swissprot - Q8BMK4
Ensembl - ENSMUSG00000046841
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 zgc:85975ENSDARG00000032405Danio rerio
 CKAP4ENSGALG00000012659Gallus gallus
 CKAP4ENSG00000136026Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR028428  Cytoskeleton-associated protein 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008150 biological_process ND
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISO
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum ISO
 cellular_componentGO:0005811 lipid droplet ISO
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface ISO
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016607 nuclear speck ISO
 cellular_componentGO:0031012 extracellular matrix ISO
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule ISO
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Surfactant metabolism
Neutrophil degranulation
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001697 abnormal embryo size "anomalous proportions of embryo compared to littermates" [cwg:Carroll W. Goldsmith, Mouse Genome Informatics Curator]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ckap4tm1b(EUCOMM)Hmgu/Ckap4+
Genetic Background: C57BL/6N-Ckap4tm1b(EUCOMM)Hmgu/Bay

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

 MP:0011968 decreased threshold for auditory brainstem response "reduction in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system" [MGI:csmith]
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Allelic Composition: Cbx2tm1b(KOMP)Wtsi/Cbx2+
Genetic Background: C57BL/6N-Cbx2tm1b(KOMP)Wtsi/H

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021789 Sftpa1 / surfactant associated protein A1 / SFTPA2* / Q8IWL1* / Q8IWL2* / surfactant protein A1* / surfactant protein A2*  / complex / reaction
 ENSMUSG00000039470 P59267 / Zdhhc2 / zinc finger, DHHC domain containing 2 / Q9UIJ5* / zinc finger DHHC-type containing 2*  / reaction






 

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