ENSGALG00000043082


Gallus gallus

Features
Gene ID: ENSGALG00000043082
  
Biological name :DHX36
  
Synonyms : DEAH-box helicase 36 / DHX36
  
Possible biological names infered from orthology : ATP-dependent RNA helicase DHX36 / Q8VHK9 / Q9H2U1
  
Species: Gallus gallus
  
Chr. number: 9
Strand: 1
Band:
Gene start: 23286957
Gene end: 23303895
  
Corresponding Affymetrix probe sets: Gga.6977.1.S1_at (Chicken Array)   Gga.6977.2.S1_at (Chicken Array)   GgaAffx.23208.1.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000052194
NCBI entrez gene - 425032     See in Manteia.
RefSeq - XM_015291824
swissprot - A0A1D5PHB6
Ensembl - ENSGALG00000043082
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx36ENSDARG00000101059Danio rerio
 DHX36ENSG00000174953Homo sapiens
 Dhx36ENSMUSG00000027770Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DHX57 / DExH-box helicase 57 / Q6P158* / Q6P5D3* / Putative ATP-dependent RNA helicase DHX57 *ENSGALG0000004155840
DHX29 / DExH-box helicase 29 / Q6PGC1* / Q7Z478* / ATP-dependent RNA helicase DHX29 *ENSGALG0000001470035
DHX30 / putative ATP-dependent RNA helicase DHX30 precursor / Q99PU8* / Q7L2E3* / DExH-box helicase 30* / Putative ATP-dependent RNA helicase DHX30 *ENSGALG0000003983029
TDRD9 / tudor domain containing 9 / Q14BI7* / Q8NDG6* / ATP-dependent RNA helicase TDRD9 *ENSGALG0000001156524
B2RR83* / Q9H6S0* / YTHDC2* / YTH domain containing 2*ENSGALG0000000018919
B2RR83* / Q9H6S0* / YTHDC2* / YTH domain containing 2*ENSGALG0000002968112


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0032206 positive regulation of telomere maintenance IEA
 biological_processGO:0043330 response to exogenous dsRNA IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0090669 telomerase RNA stabilization IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0002151 G-quadruplex RNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0051880 G-quadruplex DNA binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IEA


Pathways (from Reactome)
Pathway description
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TICAM1-dependent activation of IRF3/IRF7
TRAF6 mediated IRF7 activation
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000005947 MYD88 / A5HNF6 / Myeloid differentiation primary response protein MyD88 / Q99836* / P22366* / myeloid differentiation primary response 88* / myeloid differentiation primary response gene 88*  / complex / reaction






 

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