ENSMUSG00000027770


Mus musculus

Features
Gene ID: ENSMUSG00000027770
  
Biological name :Dhx36
  
Synonyms : ATP-dependent RNA helicase DHX36 / Dhx36 / Q8VHK9
  
Possible biological names infered from orthology : DEAH-box helicase 36 / Q9H2U1
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: E1
Gene start: 62468013
Gene end: 62507004
  
Corresponding Affymetrix probe sets: 10498415 (MoGene1.0st)   1424397_at (Mouse Genome 430 2.0 Array)   1424398_at (Mouse Genome 430 2.0 Array)   1437550_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029336
NCBI entrez gene - 72162     See in Manteia.
MGI - MGI:1919412
RefSeq - XM_011240242
RefSeq - NM_028136
RefSeq - XM_011240238
RefSeq - XM_011240240
RefSeq Peptide - NP_082412
swissprot - Q8VHK9
Ensembl - ENSMUSG00000027770
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx36ENSDARG00000101059Danio rerio
 DHX36ENSGALG00000043082Gallus gallus
 DHX36ENSG00000174953Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dhx57 / Q6P5D3 / Putative ATP-dependent RNA helicase DHX57 / Q6P158* / DExH-box helicase 57*ENSMUSG0000003505140
Dhx29 / Q6PGC1 / ATP-dependent RNA helicase DHX29 / Q7Z478* / DExH-box helicase 29*ENSMUSG0000004242635
B2RR83 / Ythdc2 / YTH domain containing 2 / Q9H6S0*ENSMUSG0000003465334
Dhx9 / DExH-box helicase 9 / Q08211*ENSMUSG0000004269931
Dhx30 / Q99PU8 / Putative ATP-dependent RNA helicase DHX30 / Q7L2E3* / DExH-box helicase 30*ENSMUSG0000003248029
Tdrd9 / Q14BI7 / ATP-dependent RNA helicase TDRD9 / Q8NDG6* / tudor domain containing 9*ENSMUSG0000005400324


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001503 ossification IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0009615 response to virus IMP
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0032206 positive regulation of telomere maintenance IEA
 biological_processGO:0043330 response to exogenous dsRNA IMP
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0090669 telomerase RNA stabilization IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 cellular_componentGO:0000781 chromosome, telomeric region IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0002151 G-quadruplex RNA binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008094 DNA-dependent ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042826 histone deacetylase binding IDA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IDA
 molecular_functionGO:0051880 G-quadruplex DNA binding IEA
 molecular_functionGO:0070034 telomerase RNA binding IEA


Pathways (from Reactome)
Pathway description
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TRAF6 mediated IRF7 activation
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000245 abnormal erythropoiesis "atypical process of red blood cell formation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000603 pale liver "liver lacking normal coloration, often refers to bloodless condition" [J:18048]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0001585 hemolytic anemia "an anemic condition resulting from an increased rate of erythrocyte destruction" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0001823 thymus hypoplasia "small size due to reduced cell number in the thymus" [J:23255]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0002416 abnormal proerythroblast morphology/development "anomalous structure, formation, or numbers of the immature, nucleated erythrocyte precursors that give rise to reticulocytes " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0002590 increased mean corpuscular volume "greater than the average amount of space occupied by each red blood cell, calculated from the hematocrit and red cell count, in erythrocyte indices" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0002640 reticulocytosis "an increase in the number of reticulocytes in the blood" [J:78271, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0002812 spherocytosis "the presence of sphere-shaped erythrocytes in the circulating blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0002874 decreased hemoglobin content "decrease in the total hemoglobin content in the circulating blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0002875 decreased erythrocyte count "reduced number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0003656 abnormal erythrocyte physiology "functional anomaly of the cells in the blood that carry oxygen, red blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0003717 pallor "an unnatural paleness to the skin, generally attributable to anemia" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0004809 increased hematopoietic stem cell number "greater cell count of the multipotent, self-renewing stem cells found in the bone marrow and the fetal liver; these give rise to all the types of both the myeloid and lymphoid cell lineages" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0004969 pale kidney "kidney lacks normal reddish coloration; often occurs with a bloodless or reduced vasculature condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0005460 abnormal leukopoiesis "anomalous process of generating white blood cells (leukocytes) from the pluripotent hematopoietic stem cells of the bone marrow; two significant pathways generate various types of leukocytes: myelopoiesis, in which leukocytes in the blood are derived from myeloid stem cells, and lymphopoiesis, in which leukocytes of the lymphatic system (lymphocytes) are generated from lymphoid stem cells" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0008475 intermingled spleen red and white pulp "no clear demarcation of the spleen red and white pulp tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Agertm1Lex/Agertm1Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0011178 increased erythroblast number "greater number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0011179 decreased erythroblast number "reduced number of the nucleated precursor of erythrocytes" [MGI:csmith]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0013697 decreased granulocyte monocyte progenitor cell number "reduction in the number of a hematopoietic progenitor cell that is committed to the granulocyte and monocyte lineages; these cells are CD123-positive, and do not express Gata1 or Gata2 but do express C/EBPa, and Pu.1" [CL:0000557, PMID:16551251]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

 MP:0013704 increased megakaryocyte-erythroid progenitor cell number "increase in the number of a progenitor cell committed to the megakaryocyte and erythroid lineages" [CL:0000050]
Show

Allelic Composition: Dhx36tm1.2Pmt/Dhx36tm1.2Pmt,Commd10Tg(Vav1-icre)A2Kio/Commd10+
Genetic Background: involves: 129P2/Ola * 129S4/SvJaeSor * C57BL/6 * C57BL/10 * CBA/Ca

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032508 Myd88 / P22366 / myeloid differentiation primary response gene 88 / Q99836* / myeloid differentiation primary response 88*  / complex / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr