ENSMUSG00000034653


Mus musculus

Features
Gene ID: ENSMUSG00000034653
  
Biological name :Ythdc2
  
Synonyms : B2RR83 / Ythdc2 / YTH domain containing 2
  
Possible biological names infered from orthology : Q9H6S0
  
Species: Mus musculus
  
Chr. number: 18
Strand: 1
Band: B3
Gene start: 44827746
Gene end: 44889724
  
Corresponding Affymetrix probe sets: 10455483 (MoGene1.0st)   1437357_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000048340
Ensembl peptide - ENSMUSP00000144479
NCBI entrez gene - 240255     See in Manteia.
MGI - MGI:2448561
RefSeq - NM_001163013
RefSeq - XM_006525915
RefSeq Peptide - NP_001156485
swissprot - B2RR83
swissprot - A0A0J9YV44
Ensembl - ENSMUSG00000034653
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LO017790.1ENSDARG00000103525Danio rerio
 ENSGALG00000000189Gallus gallus
 ENSGALG00000029681Gallus gallus
 Q9H6S0ENSG00000047188Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dhx57 / Q6P5D3 / Putative ATP-dependent RNA helicase DHX57 / Q6P158* / DExH-box helicase 57*ENSMUSG0000003505125
Dhx29 / Q6PGC1 / ATP-dependent RNA helicase DHX29 / Q7Z478* / DExH-box helicase 29*ENSMUSG0000004242623
Dhx9 / DExH-box helicase 9 / Q08211*ENSMUSG0000004269923
Dhx36 / Q8VHK9 / ATP-dependent RNA helicase DHX36 / Q9H2U1* / DEAH-box helicase 36*ENSMUSG0000002777023
Dhx30 / Q99PU8 / Putative ATP-dependent RNA helicase DHX30 / Q7L2E3* / DExH-box helicase 30*ENSMUSG0000003248020
Tdrd9 / Q14BI7 / ATP-dependent RNA helicase TDRD9 / Q8NDG6* / tudor domain containing 9*ENSMUSG0000005400317


Protein motifs (from Interpro)
Interpro ID Name
 IPR001374  R3H domain
 IPR001650  Helicase, C-terminal
 IPR002110  Ankyrin repeat
 IPR007275  YTH domain
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR020683  Ankyrin repeat-containing domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR031083  ATP-dependent RNA helicase YTHDC2-related
 IPR034083  DExH-box ATP-dependent RNA helicase, R3H domain
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR036867  R3H domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0044829 positive regulation by host of viral genome replication IEA
 biological_processGO:0070555 response to interleukin-1 IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008186 RNA-dependent ATPase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0070063 RNA polymerase binding IEA
 molecular_functionGO:1990247 N6-methyladenosine-containing RNA binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001127 small ovary "reduced size of the female reproductive gland containing the germ cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:35782]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em2Chhe/Ythdc2em2Chhe
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Ythdc2ketu/Ythdc2ketu
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ythdc2em1Sky/Ythdc2em1Sky
Genetic Background: involves: C57BL/6J * CBA

 MP:0001131 abnormal ovarian follicles "malformed or absent sac-like structure in the ovary which surrounds an ovum" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:33042]
Show

Allelic Composition: Ythdc2em2Chhe/Ythdc2em2Chhe
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em2Chhe/Ythdc2em2Chhe
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0001153 small seminiferous tubules "reduced diameter of the tubules in the testes where spermatogenesis occurs" [J:50844]
Show

Allelic Composition: Ythdc2ketu/Ythdc2ketu
Genetic Background: involves: C57BL/6J * FVB/NJ

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em2Chhe/Ythdc2em2Chhe
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2ketu/Ythdc2ketu
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ythdc2em1Sky/Ythdc2em1Sky
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Ythdc2em1Sky/Ythdc2ketu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0001926 female infertility "inability of female to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:34193]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em2Chhe/Ythdc2em2Chhe
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2ketu/Ythdc2ketu
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ythdc2em1Sky/Ythdc2em1Sky
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0002209 germ cell depletion "reduced numbers of any of the reproductive (generative) cells of a multicellular organism, whether they are undifferentiated or fully differentiated" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em2Chhe/Ythdc2em2Chhe
Genetic Background: involves: BALB/c * C57BL/6J

 MP:0002777 absent ovarian follicles "lack of the sac-like structures in the ovaries that surround the ova" [J:42612, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0004833 ovary atrophy "wasting of the ovary due to injury or disease resulting in reduced size" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ythdc2ketu/Ythdc2ketu
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ythdc2em1Sky/Ythdc2em1Sky
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Ythdc2em1Sky/Ythdc2ketu
Genetic Background: involves: C57BL/6J * CBA * FVB/NJ

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em2Chhe/Ythdc2em2Chhe
Genetic Background: involves: BALB/c * C57BL/6J

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2ketu/Ythdc2ketu
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0005168 abnormal female meiosis "malfunction in the process of nuclear division that results in ova with one half the normal chromosome number of the original cell" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0005431 oocyte depletion "reduced numbers or absence of germ cells in the female" [llw2:Linda Washburn , Mouse Genome Informatics Curator, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2ketu/Ythdc2ketu
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ythdc2em1Sky/Ythdc2em1Sky
Genetic Background: involves: C57BL/6J * CBA

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

 MP:0014052 increased male germ cell apoptosis "greater number of male germs cells that undergo programmed cell death" [MGI:csmith]
Show

Allelic Composition: Mir146tm1.1Bal/Mir146tm1.1Bal,Tifabtm1.1Dsta/Tifabtm1.1Dsta
Genetic Background: involves: 129 * C57BL/6 * C57BL/6J

Allelic Composition: Ythdc2em1Embrp/Ythdc2em1Embrp
Genetic Background: involves: C57BL/6J

Allelic Composition: Ythdc2ketu/Ythdc2ketu
Genetic Background: involves: C57BL/6J * FVB/NJ

Allelic Composition: Ythdc2em2Embrp/Ythdc2em2Embrp
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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