ENSMUSG00000042699


Mus musculus

Features
Gene ID: ENSMUSG00000042699
  
Biological name :Dhx9
  
Synonyms : DExH-box helicase 9 / Dhx9
  
Possible biological names infered from orthology : Q08211
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 153455758
Gene end: 153487660
  
Corresponding Affymetrix probe sets: 10358849 (MoGene1.0st)   1425617_at (Mouse Genome 430 2.0 Array)   1425618_at (Mouse Genome 430 2.0 Array)   1451770_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000038135
Ensembl peptide - ENSMUSP00000140764
Ensembl peptide - ENSMUSP00000139827
Ensembl peptide - ENSMUSP00000139825
Ensembl peptide - ENSMUSP00000139806
NCBI entrez gene - 13211     See in Manteia.
MGI - MGI:108177
RefSeq - XM_011247918
RefSeq - NM_007842
RefSeq Peptide - NP_031868
swissprot - A0A087WPL5
swissprot - A0A0R4J2C3
swissprot - E9QNN1
swissprot - Q3UR42
swissprot - A0A087WRT3
Ensembl - ENSMUSG00000042699
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhx9ENSDARG00000079725Danio rerio
 DHX9ENSG00000135829Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dhx57 / Q6P5D3 / Putative ATP-dependent RNA helicase DHX57 / Q6P158* / DExH-box helicase 57*ENSMUSG0000003505125
B2RR83 / Ythdc2 / YTH domain containing 2 / Q9H6S0*ENSMUSG0000003465324
Dhx29 / Q6PGC1 / ATP-dependent RNA helicase DHX29 / Q7Z478* / DExH-box helicase 29*ENSMUSG0000004242623
Dhx36 / Q8VHK9 / ATP-dependent RNA helicase DHX36 / Q9H2U1* / DEAH-box helicase 36*ENSMUSG0000002777022
Dhx30 / Q99PU8 / Putative ATP-dependent RNA helicase DHX30 / Q7L2E3* / DExH-box helicase 30*ENSMUSG0000003248020
Tdrd9 / Q14BI7 / ATP-dependent RNA helicase TDRD9 / Q8NDG6* / tudor domain containing 9*ENSMUSG0000005400319


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002464  DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR011709  Domain of unknown function DUF1605
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR014720  Double-stranded RNA-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000380 alternative mRNA splicing, via spliceosome IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0010501 RNA secondary structure unwinding IEA
 biological_processGO:0030423 targeting of mRNA for destruction involved in RNA interference IEA
 biological_processGO:0032508 DNA duplex unwinding IEA
 biological_processGO:0035549 positive regulation of interferon-beta secretion IEA
 biological_processGO:0039695 DNA-templated viral transcription IEA
 biological_processGO:0044806 G-quadruplex DNA unwinding IEA
 biological_processGO:0045739 positive regulation of DNA repair IEA
 biological_processGO:0045740 positive regulation of DNA replication IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046833 positive regulation of RNA export from nucleus IEA
 biological_processGO:0048146 positive regulation of fibroblast proliferation IEA
 biological_processGO:0050434 positive regulation of viral transcription IEA
 biological_processGO:0050684 regulation of mRNA processing IEA
 biological_processGO:0051092 positive regulation of NF-kappaB transcription factor activity IEA
 biological_processGO:0060760 positive regulation of response to cytokine stimulus IEA
 biological_processGO:0070922 small RNA loading onto RISC IEA
 biological_processGO:0070934 CRD-mediated mRNA stabilization IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071360 cellular response to exogenous dsRNA IEA
 biological_processGO:1902741 positive regulation of interferon-alpha secretion IEA
 biological_processGO:1903608 protein localization to cytoplasmic stress granule IEA
 biological_processGO:1904469 positive regulation of tumor necrosis factor secretion IEA
 biological_processGO:1904973 positive regulation of viral translation IEA
 biological_processGO:1905698 positive regulation of polysome binding IEA
 biological_processGO:2000373 positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity IEA
 biological_processGO:2000637 positive regulation of gene silencing by miRNA IEA
 biological_processGO:2000765 regulation of cytoplasmic translation IEA
 biological_processGO:2000767 positive regulation of cytoplasmic translation IEA
 biological_processGO:2000778 positive regulation of interleukin-6 secretion IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005726 perichromatin fibrils IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005844 polysome IEA
 cellular_componentGO:0015629 actin cytoskeleton IEA
 cellular_componentGO:0016604 nuclear body IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 cellular_componentGO:0035068 micro-ribonucleoprotein complex IEA
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IEA
 cellular_componentGO:0042788 polysomal ribosome IEA
 cellular_componentGO:0070578 RISC-loading complex IEA
 cellular_componentGO:0070937 CRD-mediated mRNA stability complex IEA
 cellular_componentGO:0097165 nuclear stress granule IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000993 RNA polymerase II core binding IEA
 molecular_functionGO:0001047 core promoter binding IEA
 molecular_functionGO:0001069 regulatory region RNA binding IEA
 molecular_functionGO:0001085 RNA polymerase II transcription factor binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003688 DNA replication origin binding IEA
 molecular_functionGO:0003690 double-stranded DNA binding IEA
 molecular_functionGO:0003697 single-stranded DNA binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003725 double-stranded RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IEA
 molecular_functionGO:0003729 mRNA binding IEA
 molecular_functionGO:0004003 ATP-dependent DNA helicase activity IEA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IEA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IEA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0033681 ATP-dependent 3"-5" DNA/RNA helicase activity IEA
 molecular_functionGO:0034459 ATP-dependent 3"-5" RNA helicase activity IEA
 molecular_functionGO:0035197 siRNA binding IEA
 molecular_functionGO:0035613 RNA stem-loop binding IEA
 molecular_functionGO:0043140 ATP-dependent 3"-5" DNA helicase activity IEA
 molecular_functionGO:0045142 triplex DNA binding IEA
 molecular_functionGO:0047429 nucleoside-triphosphate diphosphatase activity IEA
 molecular_functionGO:0061676 importin-alpha family protein binding IEA
 molecular_functionGO:0070063 RNA polymerase binding IEA
 molecular_functionGO:1905172 RISC complex binding IEA
 molecular_functionGO:1905538 polysome binding IEA
 molecular_functionGO:1990518 single-stranded DNA-dependent ATP-dependent 3"-5" DNA helicase activity IEA
 molecular_functionGO:1990825 sequence-specific mRNA binding IEA
 molecular_functionGO:1990841 promoter-specific chromatin binding IEA


Pathways (from Reactome)
Pathway description
RIP-mediated NFkB activation via ZBP1
DEx/H-box helicases activate type I IFN and inflammatory cytokines production
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
mRNA Splicing - Major Pathway
TRAF6 mediated NF-kB activation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001672 abnormal embryogenesis/ development "anomaly in the establishment of the characteristic configuration of the embryonic body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Dhx9tm1Ehl/Dhx9tm1Ehl
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0001675 abnormal ectoderm development "failure or abnormality in the formation of the ectoderm during gastrulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Dhx9tm1Ehl/Dhx9tm1Ehl
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0001683 absent mesoderm "missing or failure to differentiate the middle primary germ layer " [J:40594]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0001695 abnormal gastrulation "anomalous development and invagination of the embryonic germ layers" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0002145 abnormal T lymphocyte development "atypical production of or inability to produce mature T cells, and/or accumulation of T cell precursors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Terctm1Rdp/Terctm1Rdp,Tinf2tm2.2Tdl/Tinf2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * SJL

 MP:0002230 abnormal primitive streak formation "anomaly in the establishment of the midline ridge of embryonic epiblast that later develops into mesoderm and endoderm" [The Atlas of Mouse Development:ISBN 0-12-402035-6, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0003895 increased ectoderm apoptosis "increase in the number of ectoderm cells undergoing programmed cell death during development" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Dhx9tm1Ehl/Dhx9tm1Ehl
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0005030 absent amnion "missing innermost of the extraembryonic membranes" [dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0005032 abnormal ectoplacental cone 
Show

Allelic Composition: Dhx9tm1Ehl/Dhx9tm1Ehl
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Terctm1Rdp/Terctm1Rdp,Tinf2tm2.2Tdl/Tinf2+
Genetic Background: involves: 129 * BALB/cJ * C57BL/6 * SJL

 MP:0011096 complete embryonic lethality before somite formation "death of all organisms of a given genotype in a population between the point of implantation and somite formation (Mus: E4.5 to less than E8)" [MGI:csmith]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

Allelic Composition: Dhx9tm1Ehl/Dhx9tm1Ehl
Genetic Background: involves: 129S1/Sv * Black Swiss

 MP:0011186 abnormal visceral endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue which remains in contact with and surrounds the extra-embryonic ectoderm and the epiblast and provides signals for the differentiation and patterning of the epiblast; a small number of visceral endoderm cells also contribute to the endoderm of the embryonic gut" [PMID:21123814]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0011187 abnormal parietal endoderm morphology "any structural anomaly of the primitive endoderm-derived tissue that lines the luminal surface of the mural trophectoderm" [PMID:19201946]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0012105 delayed gastrulation "late onset of the development and invagination of the embryonic germ layers" [MGI:anna]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

 MP:0013504 increased embryonic tissue cell apoptosis "increase in the timing or the number of cells in embryonic tissue undergoing programmed cell death" [MGI:csmith]
Show

Allelic Composition: Vdrtm1Ska/Vdrtm1Ska
Genetic Background: involves: 129/Sv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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