ENSMUSG00000054003


Mus musculus

Features
Gene ID: ENSMUSG00000054003
  
Biological name :Tdrd9
  
Synonyms : ATP-dependent RNA helicase TDRD9 / Q14BI7 / Tdrd9
  
Possible biological names infered from orthology : Q8NDG6 / tudor domain containing 9
  
Species: Mus musculus
  
Chr. number: 12
Strand: 1
Band: F1
Gene start: 111971559
Gene end: 112068854
  
Corresponding Affymetrix probe sets: 10398759 (MoGene1.0st)   1453357_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142236
Ensembl peptide - ENSMUSP00000078022
Ensembl peptide - ENSMUSP00000141719
NCBI entrez gene - 74691     See in Manteia.
MGI - MGI:1921941
RefSeq - XM_017315218
RefSeq - XM_006516319
RefSeq - XM_006516320
RefSeq - XM_006516321
RefSeq - XM_006516322
RefSeq - NM_029056
RefSeq - XM_006516316
RefSeq - XM_006516317
RefSeq Peptide - NP_083332
swissprot - A0A0A6YY15
swissprot - A0A0A6YWV8
swissprot - Q14BI7
Ensembl - ENSMUSG00000054003
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdrd9ENSDARG00000013453Danio rerio
 TDRD9ENSGALG00000011565Gallus gallus
 TDRD9ENSG00000156414Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Dhx9 / DExH-box helicase 9 / Q08211*ENSMUSG0000004269919
Dhx57 / Q6P5D3 / Putative ATP-dependent RNA helicase DHX57 / Q6P158* / DExH-box helicase 57*ENSMUSG0000003505119
Dhx29 / Q6PGC1 / ATP-dependent RNA helicase DHX29 / Q7Z478* / DExH-box helicase 29*ENSMUSG0000004242618
B2RR83 / Ythdc2 / YTH domain containing 2 / Q9H6S0*ENSMUSG0000003465318
Dhx36 / Q8VHK9 / ATP-dependent RNA helicase DHX36 / Q9H2U1* / DEAH-box helicase 36*ENSMUSG0000002777017
Dhx30 / Q99PU8 / Putative ATP-dependent RNA helicase DHX30 / Q7L2E3* / DExH-box helicase 30*ENSMUSG0000003248015


Protein motifs (from Interpro)
Interpro ID Name
 IPR001650  Helicase, C-terminal
 IPR002999  Tudor domain
 IPR007502  Helicase-associated domain
 IPR011545  DEAD/DEAH box helicase domain
 IPR014001  Helicase superfamily 1/2, ATP-binding domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035437  SNase-like, OB-fold superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006396 RNA processing IBA
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007141 male meiosis I IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0071547 piP-body IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IBA
 molecular_functionGO:0004004 ATP-dependent RNA helicase activity IBA
 molecular_functionGO:0004386 helicase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0016887 ATPase activity IMP


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0006378 abnormal spermatogonia morphology "anomaly in the number, structure or development of the large unspecialized male germ cells that give rise to spermatocytes" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0006379 abnormal spermatocyte morphology "anomaly in the number or structure of male germ cells that through meiosis give rise to spermatids " [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0008280 male germ cell apoptosis "presence of male germs cells that undergo programmed cell death" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0008878 abnormal DNA methylation during gametogenesis "any anomaly of the covalent transfer of a methyl group to C-5 of cytosine during gamete generation, when DNA methylation patterns are established" [GO:0043046]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-R/Hrrh-R
Genetic Background: involves: 101 * C3H/Rl * C57BL/RlEl * C57BL/10Rl * SEC/El

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045662 Henmt1 / Q8CAE2 / Small RNA 2-O-methyltransferase / Q5T8I9* / HEN methyltransferase 1*  / reaction
 ENSMUSG00000036912 Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*  / complex
 ENSMUSG00000041912 Tdrkh / Q80VL1 / Mus musculus tudor and KH domain containing protein (Tdrkh), transcript variant 4, mRNA. / Q9Y2W6* / tudor and KH domain containing*  / complex
 ENSMUSG00000040629 Mael / Q8BVN9 / maelstrom spermatogenic transposon silencer / Q96JY0*  / complex






 

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