ENSMUSG00000041912


Mus musculus

Features
Gene ID: ENSMUSG00000041912
  
Biological name :Tdrkh
  
Synonyms : Mus musculus tudor and KH domain containing protein (Tdrkh), transcript variant 4, mRNA. / Q80VL1 / Tdrkh
  
Possible biological names infered from orthology : Q9Y2W6 / tudor and KH domain containing
  
Species: Mus musculus
  
Chr. number: 3
Strand: 1
Band: F2.1
Gene start: 94413273
Gene end: 94434668
  
Corresponding Affymetrix probe sets: 10494043 (MoGene1.0st)   1453366_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142561
Ensembl peptide - ENSMUSP00000142584
Ensembl peptide - ENSMUSP00000143256
Ensembl peptide - ENSMUSP00000143135
Ensembl peptide - ENSMUSP00000143102
Ensembl peptide - ENSMUSP00000142779
Ensembl peptide - ENSMUSP00000041002
Ensembl peptide - ENSMUSP00000129635
NCBI entrez gene - 72634     See in Manteia.
MGI - MGI:1919884
RefSeq - XM_017319745
RefSeq - XM_017319747
RefSeq - XM_017319744
RefSeq - XM_006502138
RefSeq - XM_017319746
RefSeq - NM_001357713
RefSeq - NM_028307
RefSeq - XM_017319749
RefSeq - XM_017319748
RefSeq Peptide - NP_001344642
RefSeq Peptide - NP_001344640
RefSeq Peptide - NP_001344641
RefSeq Peptide - NP_082583
swissprot - Q80VL1
swissprot - A0A0G2JFP5
swissprot - A0A0G2JE08
swissprot - A0A0G2JEH9
swissprot - A0A0G2JFB2
swissprot - A0A0G2JFE0
Ensembl - ENSMUSG00000041912
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 tdrkhENSDARG00000053474Danio rerio
 TDRKHENSGALG00000031812Gallus gallus
 TDRKHENSG00000182134Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tdrd5 / Q5VCS6 / Tudor domain-containing protein 5 / Q8NAT2* / tudor domain containing 5*ENSMUSG0000006098522
Tdrd6 / tudor domain-containing protein 6 isoform 3 / O60522* / tudor domain containing 6*ENSMUSG0000004014016
Tdrd1 / Q99MV1 / Tudor domain-containing protein 1 / Q9BXT4* / tudor domain containing 1*ENSMUSG0000002508114
Rnf17 / Q99MV7 / RING finger protein 17 / Q9BXT8*ENSMUSG0000000036513


Protein motifs (from Interpro)
Interpro ID Name
 IPR002999  Tudor domain
 IPR004087  K Homology domain
 IPR004088  K Homology domain, type 1
 IPR015946  K homology domain-like, alpha/beta
 IPR035437  SNase-like, OB-fold superfamily
 IPR036612  K Homology domain, type 1 superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007140 male meiotic nuclear division IMP
 biological_processGO:0007283 spermatogenesis IMP
 biological_processGO:0009566 fertilization IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA IEA
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0043046 DNA methylation involved in gamete generation IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0071546 pi-body IDA
 cellular_componentGO:0071547 piP-body IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001147 small testis "reduced size of the male reproductive glands" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58959]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

 MP:0003205 testicular atrophy "wasting of the male reproductive glands resulting in reduced size" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

 MP:0008877 abnormal DNA methylation "any anomaly in the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine of DNA" [GO:0006306]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

 MP:0009452 abnormal synaptonemal complex "an anomaly in the formation of the proteinaceous structure involved in the pairing of homologous chromosomes during first prophase of meiosis" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

 MP:0010948 abnormal double-strand DNA break repair "any annomaly in the process of repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix" [GO:0006302]
Show

Allelic Composition: Foxn1nu/Foxn1nu
Genetic Background: involves: CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045662 Henmt1 / Q8CAE2 / Small RNA 2-O-methyltransferase / Q5T8I9* / HEN methyltransferase 1*  / reaction
 ENSMUSG00000036912 Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*  / complex
 ENSMUSG00000040629 Mael / Q8BVN9 / maelstrom spermatogenic transposon silencer / Q96JY0*  / complex
 ENSMUSG00000029423 Piwil1 / Q9JMB7 / Piwi-like protein 1 / Q96J94* / piwi like RNA-mediated gene silencing 1*  / complex
 ENSMUSG00000054003 Tdrd9 / Q14BI7 / ATP-dependent RNA helicase TDRD9 / Q8NDG6* / tudor domain containing 9*  / complex






 

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