ENSMUSG00000029423


Mus musculus

Features
Gene ID: ENSMUSG00000029423
  
Biological name :Piwil1
  
Synonyms : Piwil1 / Piwi-like protein 1 / Q9JMB7
  
Possible biological names infered from orthology : piwi like RNA-mediated gene silencing 1 / Q96J94
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: G1.3
Gene start: 128702524
Gene end: 128755474
  
Corresponding Affymetrix probe sets: 10525961 (MoGene1.0st)   1460340_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142807
Ensembl peptide - ENSMUSP00000083222
Ensembl peptide - ENSMUSP00000142386
NCBI entrez gene - 57749     See in Manteia.
MGI - MGI:1928897
RefSeq - NM_021311
RefSeq - XM_006504318
RefSeq Peptide - NP_067286
swissprot - A0A0G2JEK6
swissprot - Q9JMB7
Ensembl - ENSMUSG00000029423
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 piwil1ENSDARG00000041699Danio rerio
 A6N7Y9ENSGALG00000002645Gallus gallus
 PIWIL1ENSG00000125207Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Piwil4 / Q8CGT6 / Piwi-like protein 4 / Q7Z3Z4* / piwi like RNA-mediated gene silencing 4*ENSMUSG0000003691245
Piwil2 / Q8CDG1 / Piwi-like protein 2 / Q8TC59* / piwi like RNA-mediated gene silencing 2*ENSMUSG0000003364440
Ago1 / Q8CJG1 / Protein argonaute-1 / Q9UL18* / argonaute 1, RISC catalytic component*ENSMUSG0000004153021
Ago3 / Q8CJF9 / Protein argonaute-3 / Q9H9G7* / argonaute 3, RISC catalytic component*ENSMUSG0000002884221
Ago2 / Q8CJG0 / Protein argonaute-2 / Q9UKV8* / argonaute 2, RISC catalytic component*ENSMUSG0000003669821
Ago4 / Q8CJF8 / Protein argonaute-4 / Q9HCK5* / argonaute 4, RISC catalytic component*ENSMUSG0000004250021


Protein motifs (from Interpro)
Interpro ID Name
 IPR003100  PAZ domain
 IPR003165  Piwi domain
 IPR012337  Ribonuclease H-like superfamily
 IPR014811  Argonaute, linker 1 domain
 IPR031320  GAGE
 IPR031326  Piwi-like protein 1
 IPR036085  PAZ domain superfamily
 IPR036397  Ribonuclease H superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006417 regulation of translation NAS
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007283 spermatogenesis IEA
 biological_processGO:0007286 spermatid development ISO
 biological_processGO:0010529 negative regulation of transposition IMP
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0031047 gene silencing by RNA ISS
 biological_processGO:0034587 piRNA metabolic process IMP
 biological_processGO:0035093 spermatogenesis, exchange of chromosomal proteins IMP
 biological_processGO:0051321 meiotic cell cycle IEA
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 biological_processGO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005844 polysome IDA
 cellular_componentGO:0005845 mRNA cap binding complex IDA
 cellular_componentGO:0033391 chromatoid body IDA
 cellular_componentGO:0043186 P granule ISS
 cellular_componentGO:0097433 dense body IDA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003727 single-stranded RNA binding IDA
 molecular_functionGO:0003729 mRNA binding IDA
 molecular_functionGO:0004518 nuclease activity IEA
 molecular_functionGO:0004519 endonuclease activity IEA
 molecular_functionGO:0004521 endoribonuclease activity IMP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019901 protein kinase binding IPI
 molecular_functionGO:0034584 piRNA binding IDA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001155 arrest of spermatogenesis "block of the process by which spermatogonial stem cells divide and differentiate into spermatozoa" [J:62271]
Show

Allelic Composition: Piwil1tm1.1Embrp/Piwil1+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Piwil1tm1.1Embrp/Piwil1tm1.2Embrp
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0001925 male infertility "inability of male to produce live offspring" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:60409]
Show

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

Allelic Composition: Piwil1tm1.1Embrp/Piwil1+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Piwil1tm1.2Embrp/Piwil1tm1.2Embrp
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Piwil1tm1.1Embrp/Piwil1tm1.2Embrp
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0004852 decreased testis weight "reduced average weight of the male reproductive glands" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0005159 azoospermia "absence of living spermatozoa " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Piwil1tm1.1Embrp/Piwil1+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

 MP:0006362 abnormal male germ cell morphology "any structural anomaly of male germ cells whether they are undifferentiated or fully differentiated" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

 MP:0006380 abnormal spermatid morphology "anomaly in the number or structure of the male germ cells that without further cell division give rise to mature spermatozoa" [ISBN:0-8036-0655-99 "Taber s Cyclopedic Medical Dictionary, 19th edition", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Piwil1tm1.1Embrp/Piwil1+
Genetic Background: involves: 129S4/SvJaeSor * C57BL/6

Allelic Composition: Piwil1tm1.2Embrp/Piwil1tm1.2Embrp
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

Allelic Composition: Piwil1tm1.1Embrp/Piwil1tm1.2Embrp
Genetic Background: involves: 129S4/SvJaeSor * BALB/cJ * C57BL/6

 MP:0008261 arrest of male meiosis "cessation of the progression of the process of nuclear division that results in sperm with one half the normal chromosome number of the original cell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Stat3tm1Vpo/Stat3tm1Vpo,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cAn * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000045662 Henmt1 / Q8CAE2 / Small RNA 2-O-methyltransferase / Q5T8I9* / HEN methyltransferase 1*  / reaction
 ENSMUSG00000041912 Tdrkh / Q80VL1 / Mus musculus tudor and KH domain containing protein (Tdrkh), transcript variant 4, mRNA. / Q9Y2W6* / tudor and KH domain containing*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr